Reportlinker Adds Transdermal Drug Delivery - Technologies, Markets, and Companies

NEW YORK, June 3 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Transdermal Drug Delivery - Technologies, Markets, and Companies

http://www.reportlinker.com/p0203552/Transdermal-Drug-Delivery---Technologies-Markets-and-Companies.html

Benefits of this report

• Up-to-date one-stop information on transdermal drug delivery
• Description of 116 companies involved and 101 collaborations in this area
• Market analysis 2009-2019/
• Market values in major regions
• Strategies for developing markets for transdermal drug delivery
• A selected bibliography of 170 publications
• Text is supplemented by 17 tables and 10 figures

Who should read this report?

• Biotechnology companies developing transdermal technologies
• Drug delivery companies
• Pharmaceutical companies interested in transdermal drug delivery
• Pharmaceutical research institutes

Summary

This report deals with transdermal drug delivery -- an approach used to deliver drugs through the skin for therapeutic use as an alternative to oral, intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Nanoparticles as well as the use of physical agents to facilitate transcutaneous drug delivery is described. Microneedle and needleless technologies are also described. Transdermal technologies may be applied for several categories of pharmaceuticals used for the treatment of disorders of the skin or for systemic effect to treat diseases of other organs. Several transdermal products and applications include hormone replacement therapy, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. The market for transdermal drug delivery is analyzed according to technologies and therapeutic areas from 2009 to 2019. This market is analyzed according to geographical regions as well.

TABLE OF CONTENTS

0. Executive Summary 11

1. Basics of Transdermal Drug Delivery 13

Introduction 13

Historical landmarks in transdermal drug delivery 13

Anatomy and physiology of skin 14

Transcutaneous absorption 14

Transdermal versus other methods of drug delivery 14

Advantages of transdermal drug delivery 15

First-Pass Effect 15

Drawbacks of transdermal delivery 15

Factors that influence transdermal drug delivery 15

Events governing transcutaneous absorption 16

Properties of the skin 16

Properties of drugs 17

The role of pH and pharmacokinetics 17

Intradermal disposition of drugs after topical application 18

2. Transdermal Drug Delivery Technologies 19

Introduction 19

Local application formulations 20

Crystalline topical formulations 20

Microemulsions for transdermal drug delivery 20

Transdermal gel technology 21

Film forming polymeric solutions 22

Biphasix system 22

Penetration enhancers 23

Chemical enhancers 23

Nitric oxide-based transdermal drug delivery 25

Vesicular transdermal carriers 25

Liposomes 25

Transfersomes 26

Ethosomes 26

Elastic vesicles for transdermal drug delivery 27

Nanovesicles for transdermal drug delivery 27

Transdermal patches 28

Adhesives for transdermal patches 29

Commercial development of transdermal patches 29

Innovations in transdermal patches 30

e-Patch™ controlled release micropump system 30

Patchless Transdermal Delivery System 31

Metered-dose transdermal system 31

Use of physical modalities to facilitate transdermal transport 32

Transdermal electrotransport 32

Electroporation 32

Drug delivery by electroporation 33

Cryoelectrophoresis 34

Iontophoresis 35

Iontophoresis compared with electrophoresis 36

Application of iontophoresis for drug delivery 36

Companies with technologies for drug delivery by iontophoresis 37

Combination of electrophoresis and iontophoresis 38

Dermaportation 38

Radiofrequency-driven transdermal delivery 38

Microporation 39

Transcutaneous drug delivery by electropulsation 39

Companies involved in electroporation-based drug delivery 40

Electrode Scanning System 40

Use of electrostatic force in skin patch technology 40

Multiple Absorption Kinetic System 41

Transdermal drug delivery facilitated by heat 41

Controlled, heat-aided drug delivery 41

Ultrasound 42

Magnetophoresis 43

Use of lasers for transdermal drug delivery 43

Transdermal drug delivery by laser-induced pressure waves 43

Transdermal drug delivery by laser-assisted changes in skin 44

Transdermal delivery by gas under pressure 45

Transdermal delivery with PowderJect gas gun 45

Microscission induced by gas 45

Microneedles and dermal microinjection technologies 45

Microneedle patch 45

Microneedle arrays for drug delivery 46

MicroPyramid™ hollow microneedles 47

Microstructured Transdermal Systems 47

Microneedle Array Patch technology 47

Macroflux microprojections technology 48

Companies developing microneedles for transdermal drug delivery 48

Needlefree injections 48

Glide SDI® solid dose injector 48

Jet injection 49

Mini-Ject needlefree delivery system 49

MicroJet for painless injections 49

Nanoliter-volume pulsed microjets 50

SUMAVEL™ DosePro™ needle-less injection 50

Skin ablation or abrasion for drug delivery 50

Nanotechnology-based transdermal drug delivery 51

Nanoparticles and nanoemulsions for skin disorders 51

Transdermal nanoparticle preparations for systemic effect 51

Nanotechnology-based transdermal vaccination and immunotherapy 52

Delivery of nanostructured drugs from transdermal patches 53

NanoCyte transdermal drug delivery system 53

Effect of mechanical flexion on penetration of bucky balls through the skin 53

Safety issues of applications of nanomaterial carriers on the skin 53

Comparison of transdermal drug delivery systems 54

Role of microelectronics in transdermal drug delivery 54

Transdermal drug design 54

In vitro testing of transdermal drug delivery systems 55

In vivo testing of drug delivery systems 56

Infrared spectroscopy for evaluation of transdermal drug delivery 56

Modeling of transport through the skin 56

Concluding remarks on transdermal drug delivery technologies 57

Future developments in transdermal drug delivery 58

3. Transdermal Therapeutics 59

Introduction 59

Drugs that can be administered transdermally 59

Skin disorders 62

Fungus infections of nails 62

Topical penetrating applications for nail fungus infections 62

Hair loss 62

Cardiovascular disorders 62

Angina pectoris 62

Transdermal drug delivery for hypertension 64

Transdermal beta blockers 64

Transdermal anticoagulants 64

Congestive heart failure 65

Respiratory diseases 65

Asthma 65

Chronic obstructive pulmonary disease 66

Neurological and psychiatric disorders 66

Parkinson's disease 66

Transdermal drug delivery for Parkinson's disease 67

Transdermal dopamine agonists for Parkinson's disease 67

Rotigotine 68

Transdermal administration of other drugs for Parkinson's disease 69

Depression 69

Transdermal selegiline 69

Bipolar disorder 70

Transdermal lithium 70

Restless legs syndrome 70

Alzheimer's disease 71

Transdermal nicotine for Tourette syndrome 71

Attention deficit hyperactivity disorder 71

Transdermal methylphenidate 71

Migraine 72

Transdermal lidocaine 72

Transdermal sumatriptan 72

Epilepsy 72

Tinnitus/Vertigo 73

Transdermal nitroglycerin for vasospasm due to subarachnoid hemorrhage 73

Musculoskeletal disorders 73

Osteoporosis 73

Transdermal hormonal therapy 74

Osteoarthritis 74

Transdermal insulin delivery in diabetes 74

Male sexual disorders 75

Erectile dysfunction 75

Topical and transdermal preparation for erectile dysfunction 76

Hypogonadism in the male 76

Topical testosterone 77

Women's health 78

Female sexual arousal disorder 78

Menopause 79

Hormone replacement therapy for menopause 79

Effect of transdermal estradiol on bone density 81

Transdermal testosterone for low libido in postmenopausal women 81

Breast disorders 81

Contraception 82

Female contraception 82

Male contraception 83

Cancer 83

Transcutaneous electroporation for anticancer drugs 83

Transdermal nitroglycerine for prostate cancer 84

Pain 84

Relief of pain associated with minor medical procedures 84

Transdermal Lidoderm for postherpectic neuralgia 85

Nonsteroidal antiinflammatory drugs 85

Topical NSAIDs 85

Transdermal ketoprofen 86

Topical opioids 87

Cancer pain 87

Transdermal fentanyl 87

Transdermal nitroglycerine as an adjuvant to opioids 88

Transdermal buprenorphine 89

Chronic pain of non-malignant origin 89

Postoperative pain 89

Transdermal fentanyl for the management of postoperative pain 90

Nausea and vomiting 90

Motion sickness 90

Postoperative vomiting 90

Chemotherapy-induced nausea and vomiting 90

Antiaging strategies 91

Smoking cessation 91

Transdermal nicotine replacement 91

Other methods of nicotine replacement 92

Other treatments for smoking cessation 92

Miscellaneous uses of transdermal drug delivery 93

Chronic fatigue syndrome 93

Topical androgenic steroid therapy 93

Fibromyalgia 93

Dysmenorrhea 93

Overactive bladder and urinary incontinence 93

Transdermal oxybutynin 94

Viral infections 94

Transdermal nanoparticles for immune enhancement in HIV 94

Transdermal gene therapy 95

Transdermal delivery of plasmid DNA by electroporation 95

Transdermal antisense therapy 95

Transdermal vaccination 96

The skin as an immune organ 96

Technologies for transdermal vaccination 96

Dermal microinjection technology for delivery of vaccines 96

Electroporation for administering DNA vaccines 97

Intradermal delivery of cancer vaccines by adenoviral vectors 97

Needle free delivery of vaccines 98

Transcutaneous immunization 98

Applications of transdermal vaccination 99

HIV/AIDS vaccination by topical application 99

Transdermal DNA influenza vaccine 99

Transdermal A vaccination for Alzheimer's disease 100

Transdermal vaccination for traveller's diarrhoea 100

Complications of transdermal therapy 100

Adverse effects of drugs 101

Overdose effect 101

Skin complications 101

4. Markets for Transdermal Drug Delivery 103

Introduction 103

Global markets for drug delivery 103

Geographical distribution of transdermal drug delivery markets 104

Emerging transdermal drug delivery markets in Asia 104

Transdermal technology markets in therapeutic areas 104

Angina pectoris 105

Attention deficit hyperactivity disorder 105

Erectile dysfunction 105

Hypertension 106

Pain therapeutics 106

Parkinson's disease 106

Smoking cessation 106

Transdermal hormone replacement therapy for menopause 106

Transdermal testosterone replacement therapy for hypogonadism in the male 107

Markets according to transdermal technologies 107

Marketing strategies for transdermal drug delivery 107

Marketing advantages of transdermal drug delivery 108

Unmet needs in transdermal drug delivery 108

Future prospects of transdermal drug delivery 109

Prospects of transdermal delivery for drugs coming off patents 110

Transdermal delivery of cosmetics 110

5. Companies involved in transdermal drug delivery 111

Profiles of companies 111

Collaborations 231

6. References 235

Tables

Table 1 1: Historical landmarks in the development of transdermal drug delivery 13

Table 1 2: Transdermal vs oral and intravenous drug delivery 15

Table 2 1: Technologies for transdermal drug delivery 19

Table 2 2: Chemical enhancers of skin penetration 23

Table 2 3: Drug-in-adhesive versus reservoir type of transdermal patch 28

Table 2 4: Companies developing transdermal patches for drug delivery 29

Table 2 5: Companies with technologies for drug delivery by iontophoresis 37

Table 2 6: Companies involved in electroporation-based drug delivery 40

Table 2 7: Companies developing microneedles for transdermal drug delivery 48

Table 2 8: Comparison of transdermal drug delivery systems 54

Table 3 1: Approved categories of transdermal drugs 59

Table 3 2: Current status of transdermal products 60

Table 4 1: Worldwide drug delivery market growth 2009 to 2019 103

Table 4 2: Transdermal drug delivery markets for geographical regions 2009 to 2019 104

Table 4 3: Potential therapeutic markets for transdermal products 2009-2019 105

Table 4 4: Marketing strategies based on transdermal drug delivery technologies 107

Table 5 1: Collaborations in transdermal drug delivery 231

Figures

Figure 1 1: Basic structure of the skin 14

Figure 1 2: Events governing transcutaneous drug absorption 17

Figure 2 1: Basic structure and function of transdermal drug delivery systems 28

Figure 2 2: A schematic view of electroporation 33

Figure 2 3: Depiction of breakdown of the stratum corneum during electroporation 34

Figure 2 4: A schematic drawing of Iontophoresis 35

Figure 2 5: SonoPrep ultrasonic skin permeation 42

Figure 2 6: A schematic drawing of the microneedle patch 46

Figure 3 1: Oral versus transdermal administration of a drug in Parkinson's disease 68

Figure 4 1: Unmet needs in transdermal drug delivery 109

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