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Researchers Say Flu Vaccines May Shrink Tumors and Aid in Treating Cancer

FN Media Group Presents USA News Group Market Commentary


News provided by

USA News Group

Jan 22, 2020, 08:59 ET

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LOS ANGELES, Jan. 22, 2020 /PRNewswire/ -- The questions of whether the flu shot may be the next step in fighting cancer has been raised as recent experiments in mouse models have shown that injecting an inactivated flu virus into cancer tumors can potentially make them shrink and up the effectiveness of immunotherapy treatments.

Biotech companies are actively seeking new and novel therapies that could treat a wide variety cancers. Information now emerging may offer links between drug therapies and new strategies. Leaders in this space expect increased support for new technologies from innovators in treatment and diagnostics including SIGA Technologies, Inc. (NASDAQ: SIGA), Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY), iBio, Inc. (NYSE: IBIO).

A company making major inroads is Aethlon Medical, Inc. (NASDAQ:AEMD), an up and coming medical technology company that focuses on addressing unmet needs in health and biodefense worldwide. Aethlon Medical Inc. is the developer of the Aethlon Hemopurifier, a clinical-stage immunotherapeutic device that removes exosomes and life-threatening viruses from the human circulatory system. It is also developing TauSome, an exosomal biomarker candidate to diagnose chronic traumatic encephalopathy in living individuals. Aethlon has secured Hemopurifier's® FDA designation for treating life-threatening viruses and importantly, for the treatment of individuals with advanced or metastatic cancer.

Why Flu Shots Could Help

Many factors play a part in whether or not tumors associated with cancer will respond to treatment. An important factor is whether the tumors are considered "hot" or "cold". This pertains largely to a new type of anticancer therapy that has been gaining in popularity in the form of immunotherapy. It works by boosting the body's own immune response to fight cancer tumors.

In order for the therapy to have a higher probability of being effective, the tumors have to be what is termed "hot" tumors or in other words, must contain immune cells. Tumors that do not contain immune cells, or possibly contain immunosuppressant cells, are termed "cold" tumors.

Investigators from the Rush University Medical Center in Chicago think that may now have found an effective way of turning so called cold tumors into hot ones using inactivated flu viruses. The researchers injected an inactivated influenza virus into melanoma tumors in mouse models. Their research suggests that this "vaccine" turned tumors from cold to hot by increasing the concentration of dendritic cells in the tumors. Dendritic cells are known to stimulate an immune response. In this case, they led to an increase in CD8+ T cells which can recognize and destroy cancer cells. The outcome showed that the mice's melanoma tumors either grew at a slower rate or began shrinking.

More Than One Approach May Prove Effective

Researchers and firms are exploring new ways to treat cancer and other diseases through innovations in immune therapy. Several are combining different therapies with new devices to enhance treatments. A good example is Aethlon Medical Inc. through its Hemopurifier® –one of the most fascinating, patent-protected therapeutic devices available. Aethlon's Hemopurifier® therapy works in clearing out the cancer-promoting exosomes not currently addressed by oncology and is synergistic with chemotherapy, immunotherapy and targeted agents.

After receiving its FDA "Breakthrough Device" designation, Hemopurifier® therapy also garnered attention for its role of fighting cancer in cases of chemotherapy resistance, promotion of metastasis, and immune suppression. The device was named as one of Time Magazine's Top 25 Inventions and 11 Remarkable Health Advances in 2014 and is now recognized by the National Cancer Institute. It was awarded a grant in 2018.

Aethlon recently closed its latest $5 Million Public Offering in Mid-December providing the company a strong cashed position to advance its application of the Hemopurifier®, especially in new fields. It is also developing TauSome, an exosomal biomarker candidate to diagnose chronic traumatic encephalopathy in living individuals.

Flu Vaccine May Also Help Current Therapies

Beyond lone treatment, researchers wanted to know if was possible to use flu shots as an adjuvant therapy or to aid existing anticancer therapies in improving their effectiveness. To test this, they delivered the flu shots alongside a form of immunotherapy that relies on immune checkpoint inhibitors. Those are comprised of drugs that stimulate immune cells to attack cancer tumors.

For their efforts, the researchers discovered two important things; flu vaccines were able to reduce tumor growth on their own, regardless of whether or not the targeted tumor responded to checkpoint inhibitor therapy and when a tumor did respond to immunotherapy, the flu shot combination led to an even greater reduction in the growth of the tumor. These are significant factors in aiding immunotherapy.

The work is important since humans and mice are about 95% genetically identical, so the hope is that this approach will work in human patients. According to the researchers, the next step is to conduct clinical trials to test various factors. Undoubtedly, leading biotech companies are looking to use the new technologies and capitalize on the growth in this space. Leading companies capable of playing a major role include:

SIGA Technologies, Inc. (NASDAQ: SIGA) is a commercial-stage pharmaceutical company that focuses on the health security markets in the United States. Its lead product is TPOXX, an orally administered antiviral drug for the treatment of human smallpox disease caused by variola virus. The company was founded in 1995 and is headquartered in New York, New York. SIGA recently announced that the Canadian Department of National Defense (CDND) has issued an advanced contract award notice (ACAN), indicating that it intends to award a contract to fund regulatory filing with Health Canada for approval of oral TPOXX®.

Alnylam Pharmaceuticals, Inc is a biopharmaceutical company focused on discovering, developing, and commercializing RNA interference (RNAi) therapeutics. The company's pipeline of investigational RNAi therapeutics focus on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system/ocular diseases. Alnylam has announced that the ILLUMINATE-A Phase 3 study of lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase (GO) in development for the treatment of primary hyperoxaluria type 1 (PH1), has met its primary efficacy endpoint and all tested secondary endpoints.

iBio, Inc., a biotechnology company, provides product development and manufacturing services to clients, collaborators, and third-party customers in the United States and internationally. The company's services cover the stages of pre-clinical development, regulatory approval, commercial product launch, and on-going commercial phase requirements. Its lead therapeutic candidate is IBIO-CFB03 for the treatment of systemic scleroderma, idiopathic pulmonary fibrosis, and other fibrotic diseases. 

For a more on biotech developments and the markets providing solutions, view the report at USA News Group: https://usanewsgroup.com/2020/01/03/could-this-fda-designated-breakthrough-device-literally-save-the-world-from-a-threat-that-could-wipe-out-millions-of-people-in-hours/

Article Source:
USA News Group
http://usanewsgroup.com
[email protected]

Legal Disclaimer/Disclosure:

This piece is an advertorial and has been paid for. This document is not and should not be construed as an offer to sell or the solicitation of an offer to purchase or subscribe for any investment. No information in this Report should be construed as individualized investment advice. A licensed financial advisor should be consulted prior to making any investment decision. We make no guarantee, representation or warranty and accept no responsibility or liability as to its accuracy or completeness. Expressions of opinion are those of USA News Group only and are subject to change without notice. USA News Group assumes no warranty, liability or guarantee for the current relevance, correctness or completeness of any information provided within this Report and will not be held liable for the consequence of reliance upon any opinion or statement contained herein or any omission. Furthermore, we assume no liability for any direct or indirect loss or damage or, in particular, for lost profit, which you may incur as a result of the use and existence of the information, provided within this Report.

DISCLAIMER:  USA News Group is Source of all content listed above.  FN Media Group, LLC (FNM), is a third party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated in any manner with USA News Group or any company mentioned herein.  The commentary, views and opinions expressed in this release by USA News Group are solely those of USA News Group and are not shared by and do not reflect in any manner the views or opinions of FNM.  FNM is not liable for any investment decisions by its readers or subscribers.  FNM and its affiliated companies are a news dissemination and financial marketing solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security.  FNM was not compensated by any public company mentioned herein to disseminate this press release.

This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements.

Media Contact Information:
FN Media Group, LLC
e-mail: [email protected] 
U.S. Phone: +1(954)345-0611

SOURCE USA News Group

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