SONEX HEALTH ACHIEVES ENROLLMENT TARGET IN LARGEST-EVER MULTI-ARM U.S. STUDY ON PATIENTS TREATED WITH CARPAL TUNNEL RELEASE

The landmark MISSION clinical registry is collecting real-world data across the United States and rapidly enrolled more than 1,300 patients in an 18-month timespan

EAGAN, Minn., Oct. 15, 2025 /PRNewswire/ -- Sonex Health, Inc. (Sonex Health) and The Institute of Advanced Ultrasound Guided Procedures announced today they have achieved the enrollment target in the landmark Post-Market RegIStry of the Patient Experience when uSing UltraGuIdeCTR fOr Carpal TuNnel Release (MISSION) study. This multi-arm registry has enrolled over 1,300 patients across 33 sites in 18 months.

The MISSION registry is a prospective, multicenter study that collected real-world outcomes of patients suffering from carpal tunnel syndrome (CTS) who are treated with an ultrasound-guided carpal tunnel release (UGCTR) procedure using Sonex Health's commercially available device, UltraGuideCTR™, endoscopic carpal tunnel release (ECTR), or open carpal tunnel release (OCTR) in routine clinical practice in the United States. MISSION is the largest multi-center clinical study of its kind in the United States. The goal of the MISSION registry is to compare symptom relief, functional outcomes, pain, quality of life, and patient satisfaction among the different procedural approaches to treat carpal tunnel syndrome.

"Sonex Health was founded with the mission to empower physicians with ultrasound-guided solutions that transform the patient experience by pioneering innovative therapies and skill enhancement solutions that improve patient safety and speed of recovery, which means patients can get back to activities and work much faster, decrease invasiveness, and reduce the cost of care," said Sonex Health President and CEO Bob Paulson. "This first-of-its-kind real-world comparative registry for carpal tunnel release procedures is an example of our commitment to continuously generate meaningful clinical data, which is at the heart of who we are as a company, as well as positively impacting the evolution of ultrasound-guided hand surgery procedures."

More about the MISSION clinical registry:

• The three comparator arms:
  • Ultrasound-guided carpal tunnel release
  • Endoscopic carpal tunnel release
  • Open carpal tunnel release

• Enrolled patients who qualified for treatment completed online follow-up questionnaires at 1-7 days, 2 weeks, and 1, 3, 6, 12 and 24 months after the procedure.
  
  
• Data from the MISSION registry will be shared in a series of peer-reviewed manuscripts anticipated to publish in early 2026 and will supplement the 16 peer-reviewed UGCTR publications on more than 1,300 patients and 1,700 hands already in the literature, which collectively will educate healthcare providers, their patients, and payers about the effects and outcomes of various CTR approaches.

"I am honored to serve as the principal investigator of the MISSION study," said Dr. Victor Marwin, an orthopedic hand surgeon with Bluegrass Orthopaedics in Lexington, Ky. "It is extremely important to have high-quality clinical research that assesses patient-reported outcomes among the various carpal tunnel release techniques. Studies of this magnitude ensure that physicians and their patients have access to the clinical data that will allow them to select the treatment option best suited for each individual patient."

For more information about the MISSION clinical registry, visit www.ctrstudy.com.

ABOUT SONEX HEALTH AND THE INSTITUTE OF ADVANCED ULTRASOUND GUIDED PROCEDURES

Sonex Health, Inc. is empowering physicians with ultrasound-guided solutions that transform the patient experience. As the leader in ultrasound-guided surgery, Sonex Health is dedicated to pioneering innovative therapies and skill enhancement solutions that improve patient safety, decrease invasiveness, and reduce the cost of care, supported by robust clinical research and world-class professional education and training. The company holds 51 patents with eight pipeline products and two commercial products. It has also published 16 clinical studies, with an additional eight studies planned through 2027.

The Institute of Advanced Ultrasound Guided Procedures was founded in 2018 to support the Sonex Health mission and clinical excellence and is focused on innovation supported by robust clinical research and world-class professional education and training that transforms the treatment experience for patients, providers and payers. The Institute has trained more than 800 physicians over the past four years.

For information about Sonex Health, UltraGuideCTR, and UltraGuideTFR visit www.sonexhealth.com. For more information about the Institute visit http://www.sonexhealth.com/educational-institute.

Contact:
Shelli Lissick
[email protected]
651-276-6922

SOURCE Sonex Health