Strategic Development of Neural Stem & Progenitor Cell Products

Feb 11, 2016, 16:35 ET from ReportBuyer

LONDON, Feb. 11, 2016 /PRNewswire/ -- EXECUTIVE SUMMARY

Neurogenesis is the process by which neurons are created This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain

Neural stem cells (NSCs) are the self-renewing, multipotent cells that differentiate into the main phenotypes of the nervous system These cell types include neurons, astrocytes, and oligodendrocytes Neural progenitor cells (NPCs) are the progeny of stem cell division that normally undergo a limited number of replication cycles in vivo

The terms neuronal and neural also need to be defined Technically speaking, "neuronal" means "pertaining to neurons," and "neural" means "pertaining to nerves, which are the cordlike bundles of fibers made up of neurons" Since both terms are descriptive of neurons, the scientific community uses the terms "neuronal" and "neural" relatively interchangeably The complexity of this issue is explored from a strategic perspective within this report, with emphasis on how to name neural stem cell products and therapies for optimal online and offline exposure

In summary, an understanding of neural stem cell language and terminology can substantially improve product naming, strategic positioning, and the effectiveness of marketing communications

Background of Neural Stem Cells

In 1992, Reynolds and Weiss were the first to isolate neural stem cells from the striatal tissue of adult mice brain tissue, including the subventricular zone, which is a neurogenic area Since then, neural progenitor and stem cells have been isolated from various areas of the adult brain, including non-neurogenic areas like the spinal cord, and from other species, including humans

During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate The past twenty years have seen great advances in neural stem cell research and applications Researchers have isolated NSCs, which have demonstrated pluripotency and the ability to differentiate into many different immune system cell types

In addition, NSCs can be regulated both in vitro and in vivo, which represent different commercial product opportunities Neural stem cells have also become of profound interest to the research community due to their potential to be used in drug discovery and delivery applications, as well as for tools of neural toxicology assessment NSC transplantation also represents a ground-breaking approach for treating a range of chronic neurological diseases and acute CNS injuries, including Parkinson's, Alzheimer's and spinal cord injury, among other conditions

Furthermore, neural stem and progenitor cells offer the potential to safely carry out pharmacology assessment for drugs designed to impact brain function or physiology As tests on human cells become increasingly feasible, the potential grows for companies to develop disease-specific cell assays by producing recombinant stem cell lines expressing a therapeutic target

As novel drug delivery agents, neural stem cells also show promise in killing gliomas and other cancers Finally, viable therapies for treating disease through neural stem cell transplantation are also on the horizon for forward-thinking researchers.

Market Overview for Neural Stem Cell Products

To facilitate research resulting from these advances, a large and diverse market has emerged for neural stem cell products, services, and therapies In total, the neural stem cell product marketplace is comprised of the total annual sales from all of these items, on a global basis

One thriving component of the neural stem cell marketplace is the segment that sells neural stem cell research products to scientists Termed "research supply companies" or "research product companies," large companies that dominate in this area include Thermo Fisher Scientific, STEMCELL Technologies, and EMD Millipore, as well as more than 40 other suppliers that range in size from multinational corporations to small specialty companies Together, these research supply companies represent a substantial annual percentage of NSC product sales

Currently, EMD Millipore, known as Merck Millipore outside of the United States and Canada, is the leader in neural stem cell product development for the scientific community A Canadian company, STEMCELL Technologies, is a close second in the area of NSC product development for scientists

While development of therapies that involve embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) continue to expand, development of neural stem cell therapies has been more substantially affected by barriers to entry, including patent restrictions, the dominance of current competitors, and the complexity of neural stem cell applications Currently, in the area of neural stem cell therapy development, there are currently three dominant competitors, which are Neural Stem, NeuroNova AB, and NeuroGeneration In addition to these companies, there are more than a dozen other companies actively developing neural stem cells therapies for use in the treatment of human injury and disease

Summary of Neural Stem Cell Report Findings

Growth in stem cell research has exploded over the past two decades, and the market to supply neural stem cell products and therapies has grown to meet this huge demand The proliferation of neural stem cell research since 1992 has opened the floodgates for forward-thinking companies to enter a unique product and technology marketplace

Claim this report to reveal the current and future needs of the NSC marketplace, so you can focus your marketing efforts on the most profitable products, in the most promising research areas, and within the most lucrative domestic and international markets

Key findings within this report include:
(Neural Stem Cell = NSC)

Recent Advances in NSC Research and Clinical Applications
Trend Rate Data for NSC Grants, Clinical Trials, Scientific Publications
Geographic Assessment of NSC Clinical Trial Activity
Utilization of NSCs Relative to Other Stem Cell Types
Patent Analysis for the NSC Sector
NSC Market Size Determinations, including Projections for 2016-2020
Key Acquisitions and Partnerships within the NSC Sector
Social Analytics for the NSC Marketplace, including Individual User Data and Aggregate Responses
Top-Shared NSC Articles (Trailing 12-Months)
Overview of NSCs in the Context of the Broader Stem Cell Marketplace
Company Profiles for NSC Industry Leaders

Companies mentioned in this report include:

Neuralstem, Inc
NeuroNova AB
StemCells, Inc
ReNeuron Limited
Asterias Biotherapeutics, Inc
Thermo Fisher Scientific
STEMCELL Technologies
Axol Bio
R&D Systems

Finally, the content and metrics contained in this report were compiled using a broad range of sources, including:

Stem Cell Grant Databases (RePORT Database, CIRM, MRC, Wellcome Trust)
Stem Cell Patent Databases (United States Patent and Trade Office, World Intellectual Property Organization)
Stem Cell Clinical Trial Databases (ClinicalTrialsgov, International Clinical Trials Registry Platform, European Union Clinical Trials Register )
Stem Cell Scientific Publication Databases (PubMed, Highwire Press, Google Scholar)
Stem Cell Product Launch Announcements (Trade Journals, Google News)
Stem Cell Industry Events (Google News, Google Alerts)
Stem Cell Company News (SEC Filings, Investor Publications, Historic Performance)
Interviews with Stem Cell Industry Leaders and Executives
SEC Filings and Related Investor Publications
Social Analytics Tools for Twitter, LinkedIn, Google Search, and Google Trends
BioInformant's Proprietary Dashboard of MSC Industry Metrics and 10-Year Historical Database
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