NEW ORLEANS, May 16, 2015 /PRNewswire-USNewswire/ -- Four studies evaluating effectiveness, trends and other considerations for active surveillance in managing prostate cancer will be presented during the 110th Annual Scientific Meeting of the American Urological Association (AUA). The research will be featured by study authors during a special press conference. Stacy Loeb, MD, assistant professor of urology at New York University, will moderate the session at the Ernest N. Morial Convention Center in New Orleans, LA on May 16, 2015 at 9 a.m. CT.
Active surveillance has become a viable option for many men with low-risk prostate cancer who choose not to undergo active treatment—including surgery or radiotherapy. During active surveillance, prostate cancer is carefully monitored for signs of progression through regular prostate-specific antigen (PSA) screening, prostate exams, imaging and sometimes repeat biopsies. If symptoms develop, or if tests indicate the cancer is more aggressive, active treatment may be warranted.
Publication Number: PD6-04
A Prospective, Longitudinal Active Surveillance Program for Favorable-Risk Prostate Cancer: Long Term Outcomes: Researchers from Johns Hopkins University, Baltimore, MD, found active surveillance appears to be a safer management strategy for men with "favorable risk" prostate cancer. "Favorable risk" patients are defined as patients with a Gleason score of six or less and a PSA level of 10 ng/mL or less. A long-term study evaluated data from 1,298 men diagnosed since 1995, for primary outcomes including overall survival (OS), cancer-specific survival (CSS) and metastasis-free survival (MFS). At 10- and 15-year follow up, OS was 93.2 percent and 68.7 percent, CSS was 99.9 percent and 99.9 percent and MFS was 99.4 percent and 99.4 percent, respectively. These data suggest for men with an extended life expectancy of more than 15 years, active surveillance may be the safest management strategy for men with very low risk disease.
Publication Number: MP42-04
Active Surveillance: When Can Patients Stop Worrying?: A new study conducted by researchers at Johns Hopkins University, Baltimore, MD, suggests men on active surveillance with low-risk prostate cancer can expect the likelihood of disease reclassification (increase in grade or volume) to decline with each additional stable biopsy after two years. "Low risk" prostate cancer can be defined as category T1 or T2a with a Gleason score less than or equal to six. Patients with "low risk" prostate cancer have standard PSA levels of less than 10 ng/mL. The subcategory of "very low risk" prostate cancer has the most favorable results. These men have clinical stage T1c with a Gleason score of six or less. Patients with "very low risk" prostate cancer a PSA density less than 0.15. Upon biopsy, these patients have no more than two cores with cancer, and the positive cores have no more than 50 percent cancer.
Among 808 men identified on active surveillance (557 with very-low-risk disease and 251 with low-risk disease), researchers found similar reclassification rates within the first two years. After this period, however, men in the low-risk group were twice as likely to be diagnosed with progressing disease (Gleason score >6) compared to those in the very-low-risk group. For both, risk of lifetime reclassification beyond two years decreased by 30 percent and 35 percent, respectively, after each non-reclassifying biopsy.
Publication Number: MP4-03
Contemporary Active Surveillance Rates for Newly Diagnosed Prostate Cancer Patients in Community Urology Practices: Across the country, the adoption of active surveillance as a treatment option for men with low-risk prostate cancer is on the rise, according to new research from the University of California, Los Angeles, CA; Bethesda North Hospital, Cincinnati, OH; Providence Little Company of Mary Medical Center Torrance, Torrance, CA; and Carolina Urologic Research Center, Myrtle Beach, SC. Of the 1,401 men identified in the study as meeting study inclusion criteria (a minimum of six months of documented follow-up from initial diagnosis), the average age was 63.6 years. Additionally, based on data from community-based urology practices in California, Colorado, Indiana, North Carolina, Ohio, Oregon and South Carolina, 17.3 percent had "very low"-, 36.1 percent had "low"- and 42.7 percent had "intermediate risk" prostate cancer. Across all risk groups, the primary therapy choice was active surveillance (70.2 percent of men with very low-, 39.2 percent of low, and 7.7 percent of intermediate risk of progression). Risk level, age and urology practice predicted choice of active surveillance, while race did not.
Publication Number: PD34-11
Patterns of Care for Men with Prostate Cancer Undergoing Active Surveillance as Initial Management: Despite a global increase in active surveillance as a treatment strategy for men with low-risk prostate cancer, there is no consensus on the protocol to use when following men during surveillance, and practice patterns vary widely, according to a retroactive study by researchers at New York University, New York, NY. Reviewing records for 5192 men from the SEER-Medicare linked dataset, researchers found that although most men receive at least one PSA test per year, rates of imaging and biopsies declined over time, as did the number of patients adhering to active surveillance protocols. Younger men\ and those diagnosed in more recent years had a higher frequency of surveillance biopsies.
"Active surveillance should be encouraged for men with low-risk prostate cancer that can delay or avoid the need for treatment," said Dr. Loeb. "However, the surveillance is meant to be an active process so men on active surveillance should continue to follow up with their doctor regularly."
About the American Urological Association: The 110th Annual Meeting of the American Urological Association takes place May 15-19 at the Ernest N. Morial Convention Center in New Orleans, LA.
Founded in 1902 and headquartered near Baltimore, Maryland, the American Urological Association is a leading advocate for the specialty of urology, and has more than 21,000 members throughout the world. The AUA is a premier urologic association, providing invaluable support to the urologic community as it pursues its mission of fostering the highest standards of urologic care through education, research and the formulation of health policy.
Christine Frey, AUA
SOURCE American Urological Association