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Syntekabio presenta datos no clínicos del agente inmunooncológico STB-C017 en la reunión de AACR de 2020
  • France - Français
  • Deutschland - Deutsch


News provided by

Syntekabio, Inc.

May 15, 2020, 03:00 ET

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- STB-C017 es un inhibidor dual IDO/TDO, derivado de la solución patentada de inteligencia artificial de descubrimiento de fármacos de Syntekabio, demostró un potente efecto inmunooncológico, superando la eficacia del inhibidor mono IDO, epacadostat.

- La terapia de triple combinación de inhibidores de punto de control inmune (ICIs) STB-C017, PD-1, CTLA-4 presentó la remisión completa (RC) del beneficio de supervivencia tumoral y a largo plazo.

- El desarrollo no clínico posterior y los esfuerzos de colaboración podrían producir la presentación de IND en un plazo de 2 años

DAEJEON, Corea del Sur, 15 de mayo de 2020 /PRNewswire/ -- Syntekabio (KOSDAQ: 226330), una empresa de desarrollo de fármacos basada en IA y NGS, presentó el resultado de experimentos con animales STB-C017, un inhibidor dual IDO/TDO de molécula pequeña derivado de la solución de descubrimiento de fármacos de IA de Syntekabio, en la Reunión Anual de 2020 de la American Association for Cancer Research (AACR) hoy a las 00:00 EDT.

The triple combination of  STB-C017, aPD-1 and aCTLA-4 prolongs overall survival
The triple combination of STB-C017, aPD-1 and aCTLA-4 prolongs overall survival

Chan Kim, M.D., Ph.D., profesor asociado de CHA Bundang Medical Center y el presentador de la investigación, declaró: "STB-C017 mejoró significativamente el efecto inmuno-oncológico en comparación con epacadostat. También derivó varias RC cuando se combinó con ICIs". Hong Jae Chon, M.D., Ph.D., el investigador principal, dijo: "Específicamente en el carcinoma de células renales, carcinoma hepatocelular, la combinación anti-PD-1/CTLA-4 se está convirtiendo en estándar de atención, por lo que combinar STB-C017 encima de esas combinaciones podría producir una mejora impresionante del tratamiento".

"El resultado mostró una viabilidad significativa del desarrollo posterior para STB-C017. Cuando el STB-C017 llegue al mercado, esos ICI se utilizarían de manera más amplia, lo que nos daría la oportunidad", dijo Sunil Youn, M.D., director de Desarrollo de Negocios de Syntekabio.

La presentación con los hallazgos clave se titula "Inteligencia artificial con una tecnología de aprendizaje profundo permite un desarrollo racional de un potente agente inmunoterapéutico" e incluye:

  1. STB-C017 bloqueó efectivamente la secreción de kynurenina del tumor, un inmunosupresor, y mostró relación dosis-respuesta en modelos de ratones de cáncer colorrectal.
  2. El tratamiento STB-C017 mostró infiltraciones significativas de células T CD8+ en el tumor, y la reducción de las células Treg.
  3. Régimen de dosificación STB-C017 optimizado como 5 días de administración y 2 días de descanso.
  4. La terapia combinada con anti-PD1/CTLA4 retrasó notablemente el crecimiento tumoral e indujo múltiples RC.
  • La combinación triple STB-C017 indujo un aumento doble de RC en comparación con el triple de epacadostat. Los ratones recuperados adquirieron inmunidad antineoplástica a largo plazo.
  • Los ratones tratados con la combinación triple STB-C017 mostraron un marcado beneficio de supervivencia en comparación con los demás, incluyendo el triple de epacadostat.

Syntekabio tiene previsto posteriores desarrollos STB-C017, incluyendo toxicología GLP y PKPD animal, con objetivo de presentación IND, alrededor del primer semestre de 2022. La compañía ejecutará más investigaciones traslacionales basadas en la colaboración firme con el CHA Bundang Hospital y liderará todo el alcance de los programas de desarrollo.

Foto - https://mma.prnewswire.com/media/1167087/1.jpg

Related Links

http://www.syntekabio.com

SOURCE Syntekabio, Inc.

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