BURLINGTON, Mass., April 29, 2014 /PRNewswire/ -- Decision Resources Group finds that interviewed oncologists' are optimistic that Boehringer Ingelheim's second-generation irreversible EGFR tyrosine kinase inhibitor (TKI) Gilotrif/Giotrif will offer efficacy and delivery advantages over currently available agents for the second- and subsequent-line treatment of EGFR-mutation-positive non-small cell lung cancer (NSCLC). Interviewed oncologists' are also optimistic that the third-generation EGFR TKIs CO-1686 (Clovis oncology/Celgene) and AP-26113 (Ariad pharmaceuticals) will offer competitive advantages in efficacy, safety and tolerability and delivery attributes.
The effect of an emerging therapy on key efficacy endpoints, including progression-free survival and median overall survival (MOS), has the most influence over surveyed U.S. and European oncologists' prescribing decisions for previously treated, EGFR-mutation-positive NSCLC.
The majority of surveyed managed care organization (MCO) pharmacy directors are receptive of emerging therapies that offer improvements in MOS for the treatment of this patient population.
Based on key thought leader's opinions, Gilotrif/Giotrif, CO-1686 and AP-26113 could all offer a level of MOS that, according to surveyed U.S. MCO pharmacy directors, would be necessary for inclusion on MCO formularies.
Interviewed experts are enthusiastic about the third-generation EGFR TKIs CO-1686 and AP-26113 and consider them to have the strongest clinical profiles among the current and emerging therapies for previously treated, EGFR-mutation-positive NSCLC.
Comments from Decision Resources Group Analyst Jennifer Bamford:
"Current second- and subsequent-line treatment of EGFR-mutation-positive NSCLC consists of chemotherapy regimens, which typically result in low tumor response rates and short progression-free intervals. Based on interviewed physicians and available clinical data the second- and third-generation EGFR TKI inhibitors are set to fulfill this unmet need."
"The anticipated future approval of the second- and third-generation EGFR TKIs for EGFR-mutation-positive patients will further advance the personalized treatment approach in NSCLC."
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