Two New Peer-Reviewed Studies Show OmniActive's Low-Dose Ashwagandha, Zenroot, Delivers Enhanced Bioavailability and Clinically Backed Benefits for Mood, Stress, Sleep, and Occasional Anxiety

MUMBAI, India, and BRIDGEWATER, N.J., Sept. 3, 2025 /PRNewswire/ -- Today, OmniActive Health Technologies (OmniActive) announced results from two newly published, peer-reviewed clinical studies in Advances in Therapy demonstrating the bioavailability and efficacy of Zenroot, its proprietary root-only ashwagandha (Withania somnifera) extract standardized to 1.5% withanolides. Both studies were conducted with adults between 18 and 55 years of age and used a low, efficacious daily dose of 125 mg.

In a randomized, double-blind, single-dose, cross-over, comparative, oral bioavailability study conducted with twenty healthy adults, Zenroot demonstrated:

• More than two times higher absorption than a 600 mg reference product and more than one and one-third times higher absorption than a 500 mg reference product
• The Zenroot group had significantly higher plasma withanolides content at multiple time points as compared to the reference products
• It was well-tolerated under fasting conditions

"To our knowledge, this is the most comprehensive bioavailability study of ashwagandha extract in human volunteers," said Abhijeet Morde, Divisional VP of Clinical Research at OmniActive. "By measuring individual withanolides (withanoside IV, withanolide A, 12-deoxywithastramonolide, and withaferin A) as per FDA guidance, we've set a new benchmark for ingredient transparency and performance—data that empower brands to select clinically supported solutions aligned with consumer health goals.

In a 12-week, randomized, double-blind, placebo-controlled trial, using 90 adults with mild to moderate stress, daily supplementation with Zenroot led to:

• Significant decrease in stress in less than 30 days as measured by the Perceived Stress Scale and Mindfield^® eSense Skin Response
• Reduced feelings of occasional anxiety
• Fewer mood fluctuations in response to everyday stressors, starting at day 56
• Statistically significant improvements in sleep quality by day 28 versus baseline and placebo

Market Momentum: Zenroot Meets Rising Global Demand
"The ashwagandha category is booming as consumers look for clean label, nonpharmacological solutions to support mood, sleep and stress management," said Keya Shah, Category Manager at OmniActive. "Zenroot's studies reinforce its ability to deliver a clinically validated, high-performance botanical ingredient that meets these demands in a crowded, fast-growing market. As we continue investing in new science, we see Zenroot as a cornerstone ingredient for formulators seeking to lead in the mental and overall wellness space."

According to Future Market Insights, the global ashwagandha extract market is projected to grow from $815.7 million in 2025 to $1.79 billion by 2035, at a CAGR of 8.2%. The momentum is fueled in part by younger U.S. consumers embracing adaptogens in new functional formats, while Europe is rapidly seeing growth in sports nutrition and clean-label wellness categories.

Shah further added, "Just months after its launch, Zenroot has been well-received as a root-only ashwagandha, an important distinction for product quality, safety, efficacy, and regulatory compliance in certain regions."

Zenroot is a bioavailable, root-only ashwagandha extract standardized to 1.5% withanolide content using USP methodology for consistent, trusted results. With its excellent organoleptic profile and low-dose efficacy, Zenroot is ideal for innovative delivery formats such as gummies, shots, and functional beverages.

For more on Zenroot and OmniActive's full portfolio of botanical ingredients, visit: www.omniactives.com.

About OmniActive

Established in 2005, OmniActive seeks to improve lives through innovative science and natural health solutions. OmniActive's product portfolio consists of scientifically validated, IP-protected, branded Specialty Actives and an extensive portfolio of natural Botanical Actives for global customers in the dietary supplement, functional food, and beverage markets. The company has offices in Mumbai, India, and Bridgewater, New Jersey.

Contact:
Meredith Kish
+1 973-202-4034
[email protected]

SOURCE OmniActive Health Technologies