Volition Announces Breakthrough in Enrichment of Tumor Nucleosomes

AUSTIN, Texas, Sept. 17, 2019 /PRNewswire/ --  VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition") today announced a significant milestone in its Nu.Q^TM Capture development program: the ability to enrich nucleosomes, and therefore, DNA of tumor versus non-tumor origin. This breakthrough could be used in two ways, firstly to increase specificity in Volition's current assays by removing the background signal and secondly, as an enabling technology in sequencing-based liquid biopsies by enriching nucleosomes of cancer origin from the blood.

Dr. Mark Eccleston, one of the founding Scientists and the Business Development Director at Volition commented, "I am extremely excited that this enabling technology could bridge the gap between Volition's epigenetic profiling approach to early detection and those sequencing approaches that have so far been limited to personalized treatment selection. The recent results could impact the entire sector and highlight Volition as a leader in the field of Clinical epigenetics. The next step in our Nu.Q^TM Capture development work, which is underway and will be reported in the coming months, is to determine the level of discrimination of tumor-derived nucleosomes using mass spectrometry, immunoassay and sequencing to provide a complete analysis of cell-free nucleosomes."

Dr. Jake Micallef, Chief Scientific Officer at Volition added, "Volition is focused on advancing the science of epigenetics and has developed an extensive understanding of chromosome and nucleosome structures, particularly in blood. I believe all the work we have done over the past 9 years, including what I believe should be a breakthrough patent we filed last week with the aim of securing Nu.Q^TM Capture intellectual property, puts us at the cutting edge of epigenetics."

Volition is currently developing Nu.Q^TM products that can detect cancer by measuring circulating nucleosomes in the blood by low-cost immunoassay.  In addition to these diagnostic products, Volition, through its Nu.Q^TM Capture platform, has developed the ability to enrich nucleosomes of cancer origin from the blood which will be valuable for wider profiling approaches such as mass spectrometry (for target discovery) and simplification of sequencing approaches, opening up the potential for its Nu.Q-Seq approach as well as partnering/licensing opportunities.

About Volition

Volition is a multi-national life sciences company developing simple, easy to use, cost effective blood tests to help diagnose a range of cancers and other diseases. Early diagnosis has the potential to not only prolong the life of patients, but also to improve their quality of life. The tests are based on the science of Nucleosomics^TM, which is the practice of identifying and measuring nucleosomes in the bloodstream or other bodily fluid - an indication that disease is present. Volition is primarily focused on human diagnostics but also has a subsidiary focused on animal diagnostics.

Volition's research and development activities are centered in Belgium, with additional offices in Texas, London and Singapore, as the company focuses on bringing its diagnostic products to market.

For more information about Volition, visit Volition's website (http://www.volition.com) or connect with us via:

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Nucleosomics^TM and Nu.Q^TM and their respective logos are trademarks and/or service marks of VolitionRx Limited and its subsidiaries. All other trademarks, service marks and trade names referred to in this press release are the property of their respective owners. Additionally, unless otherwise specified, all references to "$" refer to the legal currency of the United States of America.

SOURCE VolitionRx Ltd

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