Why Cranberry and D-Mannose Work With UTIs (It's Not What You Think)

With SYNEVIT^®'s FERROFECT^® Supplement, Both D-Mannose and the PACs From Cranberry Extract Work Not to Destroy, But to Eliminate Bacteria From the Urinary Tract

FORT LAUDERDALE, Fla., Aug. 13, 2025 /PRNewswire/ -- Over millions of people are regularly impacted by UTIs around the world. Many of these cases are chronic, involving an ongoing struggle to maintain urinary health and to heal from bacterial infection. SYNEVIT^®'s UTI supplement balances the safety of nature and the efficacy of technology to provide effective UTI support. The two key ingredients in the formula that help with that process? D-mannose and PACs.

"We work with in-house doctors and pharmacists with all of our formulas," explained SYNEVIT^® founder and CEO George Cvetkovski. "Everything we make uses the power of nature and the precision of science to maximize impact while staying safe and healthy. With VOLURINE^®, we've brought together two of the most potent anti-UTI agents in the natural world, using both for targeted health results."

VOLURINE^® is a complex that includes a dosage of 424mg of naturally occurring D-mannose sugar (found in many fruits) and 200 mg of cranberry extract (200:1), which is rich in proanthocyanidins or PACs. Historically, these have helped maintain a healthy urinary tract, but it was often assumed that they eliminated bacteria that had built up in the urinary tract through things like acidity. New studies increasingly show that this isn't the case.

Rather, these natural UTI-fighting agents prevent bacteria from adhering to the uroepithelial lining (the unique skin along the inside of the urinary tract). One study in 2023 combined copious previous research to observe how the proanthocyanidins (PACs) in cranberries "inhibit the adherence of p–fimbriated Escherichia coli to the urothelial cells lining the bladder." Another study from a year earlier observed how the "mechanism of action" for D-Mannose is "to prevent bacterial adherence to the uroepithelial cells."

Rather than attack bacteria or even inhibit their growth, as is the case with more aggressive antibiotics, natural solutions like D-mannose and PACs simply prevent harmful bacteria from gaining a foothold in the urinary tract. Unwanted invaders are expelled through urine, and the body remains healthy without harmful or aggressive doses of antibiotics.

VOLURINE^® is a unique UTI solution on the market today. Its combination of ingredients, a professional formula, targeted concentration, and ease of use (one tablet daily after breakfast) make it the perfect way to naturally keep the body healthier and create a preventative barrier for ongoing urinary tract health.

About SYNEVIT^®
Launched in 1998 by CEO George Cvetkovski, SYNEVIT^® traces its roots to North Macedonia (ex: Yugoslavia). The brand is currently headquartered out of North Macedonia with offices in Serbia and Rochester, New York. SYNEVIT^® is an in-house brand of vitamins and minerals with unique, perpetually improved formulas informed by on-staff doctors and pharmacists and designed for therapeutic effect in patients. Learn more at synevit.com.

Media Contact:
George Cvetkovski
[email protected]
(02) 3225 843

SOURCE Synevit