DUBLIN, May 23, 2018 /PRNewswire/ --
The "Drug Overview: Aristada" report has been added to ResearchAndMarkets.com's offering.
Aristada (aripiprazole lauroxil; Alkermes) is a long-acting injectable formulation of the atypical antipsychotic aripiprazole.
It was developed by Alkermes using its proprietary LinkeRx technology, which allows the gradual release of aripiprazole molecules and lowers the drug's frequency of administration.
Aristada acts as partial agonist at dopamine D2 and serotonin 5-hydroxytryptamine (HT)1A receptors, and displays antagonist activity at 5-HT2A receptors. This results in lower dopamine mesolimbic levels, and enhanced dopaminergic activity in the mesocortical pathway. Low levels of mesocortical dopamine appear to cause schizophrenia's negative symptoms, while an excess of mesolimbic dopamine is associated with positive symptoms.
In October 2015, Aristada was approved in the US for the treatment of schizophrenia. The drug is not currently being developed for the Japanese or EU markets.
Key Topics Covered
- Drug Overview
- Product Profiles
- Aristada: Schizophrenia
List of Figures
Figure 1: Aristada for schizophrenia - SWOT analysis
Figure 2: Drug assessment summary of Aristada for schizophrenia
Figure 3: Drug assessment summary of Aristada for schizophrenia
Figure 4: Aristada sales for schizophrenia in the US, 2017-26
List of Tables
Table 1: Aristada drug profile
Table 2: Aristada pivotal trial data in schizophrenia
Table 3: Aristada other late-phase trial data in schizophrenia
Table 4: Aristada ongoing trial in schizophrenia
Table 5: Aristada sales for schizophrenia in the US ($m), 2017-26
For more information about this report visit https://www.researchandmarkets.com/research/wthkxw/drug_overview?w=5
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SOURCE Research and Markets