Baszucki Group Awards $6M to Pittsburgh Psychiatry-Led Research Team to Study Mechanisms of Ketogenic Diet in Bipolar Disorder

Funding will support the creation of a multidisciplinary research team focusing on the intersection of neuroscience, psychiatry, and metabolism

SAN MATEO, Calif., March 21, 2024 /PRNewswire/ -- Today, Baszucki Group announced $6 million in funding awarded to a research team led by University of Pittsburgh Psychiatry professor and researcher, Mary L. Phillips, MD, MD (Cantab). The philanthropic gift unites leaders across affective neuroscience, neuroimaging, mitochondrial biology, and cellular models to elucidate the neurobiological mechanisms underlying the therapeutic effect of the ketogenic diet in bipolar disorder, with an emphasis on symptoms of hypomania and mania.

"With this generous support from Baszucki Group, we embark on an ambitious endeavor to interrogate, for the first time, the relationship between gene expression, mitochondrial function, and brain markers associated with a ketogenic diet's impact on symptoms of mania and hypomania," said Dr. Mary Phillips, Distinguished Professor of Psychiatry, Clinical and Translational Science, and Bioengineering, and Pittsburgh Foundation-Emmerling Endowed Chair in Psychotic Disorders in the Department of Psychiatry at the University of Pittsburgh.

Dr. Phillips is a trained psychiatrist and Director of the Phillips Mood and Brain Laboratory which specializes in mood disorders. She is internationally recognized for her research on emotional and reward processing in the human brain, and how dysregulation of these systems contributes to serious mental illnesses—producing over 400 research publications. The research team also includes Zachary Freyberg, MD, PhD, Associate Professor of Psychiatry and Cell Biology, University of Pittsburgh, Colleen McClung, PhD, Professor of Psychiatry and Clinical and Translational Science, University of Pittsburgh, and Ana Andreazza, PhD, Professor of Pharmacology & Toxicology and Psychiatry, University of Toronto.

"This investment underscores our continued commitment to supporting rigorous, scientific inquiry to test potentially transformative clinical interventions like ketogenic therapy, which sent our son's bipolar illness into remission," said Jan Ellison Baszucki, co-founder and President of Baszucki Group. "With genetic, metabolic, molecular, and neural network investigations, this research has the power to lead to new insights into the mechanisms of bipolar mania, as well as precision neurometabolic interventions."

The $6 million gift is the second grant in Baszucki Group's newly-announced research program: ReThink Bipolar: Researching Therapeutic Integration of Nutritional Ketosis in Bipolar Disorder. ReThink Bipolar builds on Baszucki Group's prior investments in bipolar disorder therapeutic research, as well as six pilot trials of ketogenic therapy for serious mental illness, including bipolar disorder, schizophrenia, major depression, and anorexia nervosa.

About Baszucki Group
Launched in 2021 by Roblox founder and Chief Executive Officer David Baszucki and best-selling author Jan Ellison Baszucki, Baszucki Group leverages private giving, impact investing, advocacy, storytelling and community building to drive foundational change. A primary objective of Baszucki Group is to transform mental health outcomes, beginning with bipolar disorder, by supporting initiatives at the intersection of metabolism, psychiatry, and neuroscience. To learn more about metabolic approaches to mental disorders, including ketogenic therapy, visit Metabolic Mind, a nonprofit initiative of Baszucki Group.

SOURCE Baszucki Group