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Eirion Therapeutics, Inc. Closes $40 Million Series A Investment and Licensing Deal with Shanghai Haohai Biological Technology Ltd.

(PRNewsfoto/Eirion Therapeutics, Inc.)

News provided by

Eirion Therapeutics, Inc.

Mar 09, 2021, 08:31 ET

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WOBURN, Mass., March 9, 2021 /PRNewswire/ -- Today, Eirion Therapeutics, Inc., an aesthetic dermatology company headquartered in Woburn, Massachusetts, announced a deal with Shanghai Haohai Biological Technology Ltd. ("Haohai") that will result in a $32 million Series A Preferred Stock investment into Eirion along with exclusive licenses that will be for all of Eirion's products for the territory of China in exchange for an upfront payment in the amount of $8 million. The deal is structured in segments over the next approximately 18 months. Haohai is a leading Chinese aesthetic medicine company headquartered in Shanghai and is publicly traded on the Hong Kong (6826.HK) and Shanghai (688366.SS) stock exchanges. 

"This transaction allows Haohai to bring Eirion's very innovative product candidates into China. As a leading aesthetic company with products ranging from dermal fillers to electro-optic equipment in China, Eirion's highly complementary products have the potential to catapult Haohai to becoming a dominant player in Chinese aesthetic field," said Haohai's Chairman Dr. Yongtai Hou. 

Haohai is investing $31 million and a US investor is co-investing $1 million in Eirion that in aggregate will obtain a minority stake in the company. Eirion has been funded previously through approximately $11 million of convertible notes which will convert into Series A Preferred Stock in connection with Haohai's investment.

"We are thrilled to partner with Haohai, an established aesthetics leader in China, a country poised to become the largest aesthetic market in the world. Together, we look forward to accelerating innovation in the global marketplace," commented Jon Edelson, MD, Eirion's Chairman, CEO, and President.  

The companies have signed two product licenses that have the potential in aggregate to provide Eirion approximately $43 million in development fees, $444 million in sales milestones, with product royalty rates ranging from high single digits to the low twenties. One license is for Eirion's neuromodulator-based product candidates, ET-01 (topical) and AI-09 (injectable) for aesthetic indications; and a second license is for Eirion's small molecule product candidates, ET-02 (topical) and ET-03 (oral), which are intended for the treatment of hair loss and hair greying. Under the terms of the licenses, the products will be manufactured in the US by Eirion and developed and commercialized by Haohai in China.

"My work as a clinical advisor and investigator with the Eirion team has given me a front row seat to see the Eirion team's commitment to scientific rigor and the aesthetic dermatology space. This transaction gives Eirion an even greater platform and set of resources to realize and expand the opportunities that they have identified," stated Kenneth Beer, MD. Dr. Beer is a noted clinical investigator and dermatologist in private practice in Florida.

Eirion's Technology

Eirion has invented a proprietary approach to topical neuromodulator treatment: before the application of the topical neuromodulator, the skin will be pre-conditioned by a device that will create temporary micropores that aide in the absorption of the neuromodulator into the skin. The topical neuromodulator itself employs a patented nanoemulsion delivery system. The treatment in total is intended to avoid the pain and potential bleeding, bruising and needle misplacement that can associated with the current hypodermic needle administration used for all commercial neuromodulators today.

Eirion's Clinical Product

Eirion's lead product ET-01 is a Phase 2 topical neuromodulator product candidate being developed for the treatment of lateral canthal lines (Crow's Feet wrinkles) and primary axillary hyperhidrosis (excessive underarm sweating). In its Phase 2 clinical trials to date using its drug-device combination, Eirion has observed the potential for ET-01 to treat wrinkles, with results that are statistically significant, showing improvements measured at muscular contraction when the Crow's Feet wrinkles appear at their worst on the face. Eirion has also observed promising effects and duration of effects of a single application of ET-01 in the physician's office when compared to the effects of a single injection observed in published studies of a commercially available neuromodulator. Eirion plans to begin a Phase 2b study this year to further study the efficacy and safety of ET-01.

Eirion's Pre-Clinical Products

Eirion is developing a next generation ready-to-use liquid injectable neuromodulator product called AI-09 for the treatment of glabellar (frown) lines. Eventually, AI-09 may be developed for other aesthetic and medical indications. AI-09 will be provided as a ready-to-use, liquid formulation, which contrasts favorably to currently commercialized neuromodulator products that all require reconstitution with saline in the physician's office before use. As well, in contrast to current injectable products, AI-09 does not contain human albumin, which carries a risk of disease transmission. Both ET-01 and AI-09 have been shown to be stable at room temperature for at least 3 months, which is also an advantage over current products that require shipping to and storage at the physician's office in frozen conditions. Eirion plans to file an IND for AI-09 later this year.

Eirion's pre-clinical product candidates ET-02 and ET-03, which contain the same small molecule, employ a brand-new mechanism of action which corrects an aging defect in the hair follicle stem cells that Eirion has discovered causes androgenic alopecia (hair loss) and hair greying. Eirion believes that ET-02 and ET-03 can either prevent the defect from occurring or reverse the defect which would result in either new hair growth in those who have lost hair or the return of hair color for those how have turned grey. Eirion believes our product candidates are the first potential pharmaceutical treatments in development for hair greying.

In controlled non-clinical studies of human scalp tissue affected by androgenic alopecia, ET-02 demonstrated approximately twice the hair growth compared to a control treatment over approximately 4 months, which was statistically significant, and amounted to approximately three times the hair growth per centimeter over that which was observed in minoxidil clinical trials that were 12 months in duration. Eirion plans to launch its first clinical trial of ET-02 next year.

About Eirion Therapeutics, Inc.

Eirion Therapeutics, Inc. is a privately held, clinical stage biopharmaceutical company that is developing next-generation prescription products for aesthetic dermatology. Eirion currently has a rich pipeline of products focusing on treatments for wrinkles, primary axillary hyperhidrosis, androgenic alopecia, and hair greying. In the future, Eirion plans to also pursue additional indications that address other major unmet clinical needs for physicians and their patients. At the 2020 Fall Clinical Dermatology conference, Eirion competed in, and then won, the business "shark tank" contest called the Skin Health Innovation Competition. For more information, please go to www.eirionthera.com.

About Shanghai Haohai Biological Technology, Ltd. 

Haohai Biological Technology is a leading company in China focusing on the research and development, manufacturing and sales of biomedical materials. Haohai strategically targets the fast-growing therapeutic areas including medical aesthetics, ophthalmology, wound care, orthopedics, and hemostasis.  Haohai's dermal filler products include Hyalumatrix, Matrifill and Janlane. Haohai is traded on the Hong Kong and Shanghai stock exchanges.

For Press Inquiries Contact:
Megan Driscoll
EvolveMKD
646.285.7165
[email protected]

SOURCE Eirion Therapeutics, Inc.

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