Unlocking mRNA Performance: How Sequence Engineering and GMP Integration Accelerate Therapeutic Success, Upcoming Webinar Hosted by Xtalks

In this free webinar, gain insight into how mRNA performance can be strengthened through sequence design and GMP-aligned development strategies. Attendees will learn how codon optimization and UTR design influence IVT efficiency, translational output, mRNA stability and manufacturability. The featured speakers will discuss the sequence-level decisions that drive yield, capping efficiency, dsRNA formation and LNP performance. The speakers will share practical design principles that strengthen the potency, durability and scalability of mRNA constructs. Attendees will learn about common disconnects between sequence design and GMP production and strategies to avoid them. The speakers will share insights into workflows that improve handoffs between R&D, CMC and GMP teams, reducing technical risk and accelerating timelines.

TORONTO, Dec. 3, 2025 /PRNewswire/ -- Developers of mRNA therapeutics face an increasingly complex landscape: rising expectations for potency and durability, evolving regulatory guidance and persistent challenges in scaling from exploratory design to GMP manufacturing. While attention often focuses on downstream process improvements, many of the most influential determinants of expression, manufacturability and clinical performance originate at the sequence level. This webinar examines how sequence-level decisions shape mRNA performance and how aligning design with manufacturing expectations can reduce development risk.

The featured speakers will examine how rational sequence engineering, particularly codon optimization, UTR selection and regulatory element tuning, shapes the performance and production readiness of mRNA constructs. The session will outline how specific sequence features influence transcription efficiency, IVT yield, capping outcomes, dsRNA formation and translational efficiency, drawing on experimental findings from RBIx's RevSelect™ platform. Beyond sequence design, the webinar will explore how upstream decisions translate into downstream implications across development, tech transfer and GMP manufacturing.

The speakers will discuss practical considerations for aligning sequence optimization with real-world process capabilities, analytical expectations and quality requirements for pDNA, mRNA, LNP formulation and sterile fill/finish. Examples will illustrate where misalignment between design and production often leads to delays and how integrated workflows can help avoid those pitfalls.

Participants will gain a clearer understanding of:

• How to evaluate codon and UTR choices for manufacturability and potency
• Which sequence-level attributes most strongly affect IVT efficiency and mRNA stability
• How early data packages can support smoother process development and regulatory readiness
• Strategies for improving continuity between design, development and GMP production

Attendees will come away with actionable insights that can help de-risk development programs, reduce iteration cycles and improve the likelihood of successful IND-enabling production.

Register for this webinar to learn how mRNA performance can be strengthened through sequence design and GMP-aligned development strategies.

Join Jessica Madigan, Director, Business Development, Nucleic Acid Modalities, BIOVECTRA; Manika Bhondeley, PhD, Senior Scientist, Revolution Biomanufacturing; and Molly McGlaughlin, Chief Executive Officer, Revolution Biomanufacturing, for the live webinar on Tuesday, December 16, 2025, at 2pm EST (11am PST).

For more information, or to register for this event, visit Unlocking mRNA Performance: How Sequence Engineering and GMP Integration Accelerate Therapeutic Success.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars and digital content to the global life science, food, healthcare and medical device communities. Every year, thousands of industry practitioners (from pharmaceutical, biotechnology, food, healthcare and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps professionals stay current with industry developments, regulations and jobs. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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Vera Kovacevic
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