Nuance Pharma Announces First Patient Dosed in REACH Phase III Trial of STG320 (Actair®) in China

SHANGHAI, Oct. 30, 2026 /PRNewswire/ -- Nuance Pharma announced that the first patient has been dosed in the REACH Phase III clinical trial evaluating STG320 (Actair®) for the treatment of house dust mite-induced allergic rhinitis in China.

Stallergenes Greer's Actair® is a sublingual tablet currently marketed in 21 countries and territories under brand names including Actair®, Orylmyte® and Aitmyte®. Further market expansion is underway.

Actair Study in China

On May 22^nd, 2026, Nuance Pharma announced that the National Medical Products Administration (NMPA) has cleared its Investigational New Drug (IND) application, designed to initiate a pivotal clinical trial of Actair® for the treatment of house dust mite-induced allergic rhinitis in China.

In October 2026, Nuance Pharma announces the first patient dosed in the REACH Phase III trial, a randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Actair® over a 12-month treatment period in patients with allergic rhinitis, with or without concomitant asthma.

"We are excited to announce the first patient dosing in the REACH Phase III trial. Together with the progress made through our early access programs, this achievement moves us one step closer to delivering a new allergy treatment to Chinese patients," said Mark Lotter, Founder and Chief Executive Officer of Nuance Pharma. "Actair® offers an innovative approach to treating house dust mite allergy, and we look forward to introducing this innovation in China as soon as possible," said Dr. Charlie Chen, Chief Operating Officer of Nuance Pharma.

"We are pleased our development partner, Nuance Pharma, has begun pivotal studies with Actair® in mainland China," said Anette Weber, Chief Executive Officer a.i. of Stallergenes Greer. "This is a significant achievement and, given Actair®'s established commercial track record across 21 countries, we are excited about its potential to address the growing demand for innovative allergy treatments among Chinese patients."

The first patient dosing follows a series of recent milestones reinforcing Nuance Pharma's commitment to the Chinese allergy market. In September 2025, the company entered into an exclusive long-term partnership with Stallergenes Greer for the development and registration of Actair® in China, with Nuance Pharma retaining responsibility for subsequent commercialization. In January 2026, Actair® received approval from the Pharmaceutical Administration Bureau of Macau. In May 2026, Nuance Pharma launched Actair® in China's Hainan Boao Pilot Zone through an early access program. Most recently, in May 2026, the National Medical Products Administration (NMPA) has cleared Actair® Investigational New Drug (IND) application.

About Nuance Pharma

Nuance Pharma is an innovation-driven biopharmaceutical company with a late-stage clinical pipeline and a portfolio of commercial-stage assets. Focused on specialty care, Nuance has established a differentiated combination of commercialized products and an innovative pipeline spanning respiratory disease. With a mission to address critical unmet medical needs across the Asia-Pacific region, Nuance Pharma deploys its proprietary Dual Wheel model — simultaneously advancing a globally competitive pipeline while maintaining a self-sustaining commercial operation in China and across Asia.

For more information, please visit www.nuancepharma.com

About Stallergenes Greer International AG

Headquartered in Baar, Switzerland, Stallergenes Greer is a global healthcare company specializing in the diagnosis and treatment of allergies through the development and commercialization of allergen immunotherapy products and services. Backed by more than 120 years of expertise and innovation, its products are available to patients in 46 countries.

For more information, please visit www.stallergenesgreer.com

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SOURCE Nuance Pharma Limited