Advanced Orthopedic Technologies, Implants and Regenerative Products

NEW YORK, Aug. 25, 2014 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Advanced Orthopedic Technologies, Implants and Regenerative Products

http://www.reportlinker.com/p096659/Advanced-Orthopedic-Technologies-Implants-and-Regenerative-Products.html

This BCC Research report provides an overview of products in the advanced orthopedic market, offers detailed market analyses and discusses competitive environments. The study includes information about significant products and players, issues and trends, as well as other data affecting the orthopedic device industry over the next five years.

Use this report to:
- Receive a detailed analysis of the global market for advanced orthopedics by product segment and region.
- Learn about the significant products and players, issues and other data affecting the orthopedic device industry.
- Learn about the advanced orthopedic technology industry's participants.
- Gain insight into the market's potential including trends that are and will continue to drive growth in the future.

Highlights
- BCC Research estimates that the global market for advanced orthopedics will grow from $35.3 billion in 2013 to nearly $36.4 billion in 2014, continuing to increase at a compound annual growth rate (CAGR) of 3.0% for the period of 2014 to 2019 reaching nearly $42.2 billion in 2019.
- The global market for joint replacement, implant, and regenerative products is expected to grow from about $30.1 billion in 2014 to $34.4 billion in 2019, with a CAGR of 2.7% over the forecast period.
- The global market for cartilage, soft tissue repair, and regenerative products will increase at a CAGR of 6.6% to reach about $2.5 billion in 2019, up from an estimated $1.8 billion in 2014.

Introduction & Scope
INTRODUCTION
STUDY GOALS AND OBJECTIVES
This report provides an overview of products in the advanced orthopedic market, offers detailed market analyses and discusses competitive environments. The study includes information about significant products and players, issues and trends, as well as other data affecting the orthopedic device industry.

REASONS FOR DOING THE STUDY
With technology advancements and a better understanding of the body, the orthopedic device market offers a range of highly complex and leading-edge products. They now
are a significant part of the industry. While there are many conventional and generally less expensive products, new items and biotechnological advancements are beginning
to revolutionize future growth of the orthopedic device market. The latest technological products are competing in a fast track market that looks to improve the quality of life
for millions of individuals who need procedures such as hip and knee transplants.

Ongoing patient management studies, combined with a drive to produce technologically superior products, will increase the number of patients who can benefit from developments in the advanced orthopedic product market. This study will provide readers with the knowledge needed to adequately view and assess this market and will
provide insights into the market potentials, including trends that are driving and will continue to drive this segment in the future.

CONTRIBUTION OF THE STUDY AND INTENDED AUDIENCE
The intended audience includes all the stakeholders in the orthopedic device and products industry: developers of medical devices; device manufacturing companies,
medical supply vendors, hospitals, surgeon offices; physician offices and groups, development companies, and other involved participants. This includes mostly manufacturers, suppliers, technology providers, and research and development (R&D) companies.

With its broad scope and in-depth analyses, this study will prove to be a valuable resource to anyone involved with or interested in the history and future direction of
orthopedic industry. This study will provide information on these areas:
- Structure and current market size of the advanced orthopedic technologies, implants and regenerative product market as outlined with forecasts through 2019.
- Impact of chronic diseases, and growing and aging populations.
- Current product suppliers and some of their technologies.
- A look at the health industry and trends affecting the market.
- Markets for U.S., Europe and Asia-Pacific regions by each segment.
- Technology patent trends relating to orthopedic devices.
- Profiles for more than 15 leading companies in the industry with significant contributions and market shares.

Since the study provides business and technical information of a timely nature, it will prove valuable to a variety of readers, including industry executives, managers and
planners, purchasers, industry analysts and investors. The projections, forecasts and trend analyses found in this report provide readers with the necessary data and
information for careful decision-making and on which products will continue to be demanded by the industry.

SCOPE OF THE REPORT
This study will be a helpful business tool providing a thorough evaluation of the advanced orthopedic market. Its geographic scope is global, with special emphasis on
the U.S., Europe and Asia-Pacific. The report identifies markets in three general segments:

- Bone repair and regenerative products.
- Cartilage and soft tissue repair and regenerative products.
- Joint replacement, implants and regenerative products.

Each market segment provides detailed information based on product categories, product use, forecasts and competitive analyses. Advanced orthopedics deals with those products involving new techniques and next-generation therapies. They provide a significant patient outcome over traditional methods, as well as improving healing and lowering overall care costs. These products incorporate biotechnological advancements and improved methods for dealing with orthopedic injuries and conditions.

Products in this study are considered to be at the forefront of orthopedic device technology. Products not considered advanced include external bracing, slings, casting
materials and so forth. Those classified by industry experts as advanced orthopedic products include: human bone products and materials, bone-growth stimulators,
synthetic bone replacements, cartilage and soft tissue fixation systems, biologics/biomaterials, complex joint replacement devices, spine devices, and joint fluid
replacements.

METHODOLOGY
The information for this report was obtained through primary and secondary data collection methods. Primary sources included interviews with more than 50 key
executives, product managers, clinical specialists and other related key personnel involved with the orthopedic industry. Secondary sources included published literature,
investment reports, company literature and various business journals that have emphases on orthopedic devices and related areas.

Market data for this report pertain to the world market in U.S. dollars at the manufacturers' level. The base year of the report is 2014, with historical data provided from 2010 through 2013 and with forecast data provided for 2019. Historical, base year and forecast data are provided for each market segment of the report. Growth rates are determined through a compilation of data including past trends, future trends, demographics, incidence, mortality, products in R&D, current product growth and so
forth. Competitor market share estimates are provided for each market segment for the 2014 base year.
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
CONTRIBUTION OF THE STUDY AND INTENDED AUDIENCE 2
SCOPE OF THE REPORT 3
METHODOLOGY 3
PREVIOUS EDITIONS 4
RELATED BCC RESEARCH REPORTS 4
ANALYST'S CREDENTIALS 4
BCC RESEARCH WEBSITE 5
DISCLAIMER 5
CHAPTER 2 SUMMARY 7
SUMMARY TABLE GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT
SEGMENT, THROUGH 2019 ($ MILLIONS) 9
SUMMARY FIGURE ADVANCED ORTHOPEDIC TECHNOLOGY, IMPLANTS AND
REGENERATIVE PRODUCTS, 2010-2019 ($ MILLIONS) 9
CHAPTER 3 INDUSTRY OVERVIEW 11
HISTORY OF THE ORTHOPEDIC INDUSTRY 11
ADVANCED ORTHOPEDIC MARKET DEVELOPMENT 11
GOVERNMENT REGULATION OF DEVICES 11
REGULATION, COST AND CLASSIFICATION OF DEVICES BY REGION 12
Costs 12
U.S. (FDA) 12
510(k) Exemptions 13
TABLE 1 PARTS 862-892 OF 21 CFR 14
Humanitarian Device Exemption (U.S.) 14
TABLE 2 LISTING OF ORTHOPEDIC-RELATED CDRH HUMANITARIAN DEVICE
EXEMPTIONS, THROUGH MARCH 2014 15
Investigational Device Exemption 17
Changes in FDA Advisor Roles 17
Canada (Health Canada) 18
Europe (MDD) 18
Japan 20
TABLE 3 NUMBER OF MEDICAL DEVICES APPROVED WITH CLINICAL DATA REVIEW,
2006-2011 21
Japanese Medical Device Nomenclature (JMDN) Codes for
Orthopedic Devices 21
TABLE 4 JAPANESE MEDICAL DEVICE NOMENCLATURE CODES FOR ORTHOPEDIC
DEVICES 22
Australia 23
Reclassification of Specific Orthopedic Implants 23
TREATMENT SETTINGS 24
Ambulatory Treatment Facilities 24
TABLE 5 U.S. AMBULATORY VISITS ALL AGES BY FACILITY TYPE, 1996-2010 24
TABLE 6 U.S. EMERGENCY ROOM VISITS BY INJURY LOCATION AND SPORT/ACTIVITY,
2008 DATA 24
TABLE 7 U.S. EMERGENCY ROOM VISITS BY BODY SITE, 2010 DATA (THOUSANDS) 25
Orthopedic Rehabilitation Facilities and Physical Therapy 25
Orthopedic Surgeons 26
TABLE 8 ACTIVE U.S. PHYSICIANS BY SELECTED SPECIALTY, 1980-2010
(THOUSANDS) 26
CHAPTER 4 ISSUES AFFECTING THE MARKET 28
INSURANCE AND REIMBURSEMENT ISSUES 28
TABLE 9 MEDICARE REIMBURSEMENT RATES FOR COMMON ORTHOPEDIC
PROCEDURES, NATIONAL PAYMENT AMOUNT, 2009 AND 2014 (DOLLARS) 29
ECONOMICS AND HEALTH CARE 30
TABLE 10 HEALTH EXPENDITURES AS PERCENTAGE OF GDP BY SELECT COUNTRY,
1980-2015 (%) 31
FIGURE 1 HEALTH EXPENDITURES AS PERCENT OF GDP BY COUNTRY: 1980-2015
(%) 31
MEDICAL DEVICE PRICING TRENDS 32
MARKETING AND ADVERTISING ISSUES AND TRENDS 32
LEADING MANUFACTURERS' STRATEGIES 33
Manufacturing, Distribution and Supply 33
TABLE 11 ADVANCED ORTHOPEDIC MANUFACTURING AND SUPPLY FACILITIES 34
Alphatec 35
ArthroCare 35
Biomet Inc. 36
DJO Surgical 36
Exactech 36
Genzyme BioSurgery 36
LifeCell 36
NuVasive 37
Smith & Nephew 37
Stryker 37
Wright Medical 37
Zimmer Holdings 38
Sales and Marketing 38
TABLE 12 ADVANCED ORTHOPEDIC SALES AND MARKETING EXPENDITURES BY
MANUFACTURER FOR FISCAL YEAR 2009-2013 ($ MILLIONS) 38
FIGURE 2 ADVANCED ORTHOPEDIC SALES, MARKETING AND ADMINISTRATIVE
EXPENDITURES BY MANUFACTURER FOR FISCAL YEAR 2009-2013 ($ MILLIONS) 39
Alphatec 40
ArthroCare 40
Biomet Inc. 41
Conmed 41
Exactech 41
Integra Life Sciences 41
Smith & Nephew 41
Stryker 42
Wright Medical 42
Zimmer Holdings 42
Research and Development Trends 43
TABLE 13 RESEARCH AND DEVELOPMENT EXPENDITURES FOR ADVANCED
ORTHOPEDIC MANUFACTURERS AND SUPPLIERS, 2008-2013 ($ MILLIONS) 43
FIGURE 3 RESEARCH AND DEVELOPMENT EXPENDITURES FOR ADVANCED
ORTHOPEDIC MANUFACTURERS AND SUPPLIERS, 2008-2013 ($ MILLIONS) 43
Acquisitions, Alliances and Agreements 44
Alphatec 44
Conmed 45
Exactech 45
Integra Life Sciences 45
Medtronic 45
NuVasive 46
Smith & Nephew 46
Stryker 46
Wright Medical 46
Zimmer Holdings 47
Employee Snapshot and Distribution 47
TABLE 14 EMPLOYEE DISTRIBUTION FOR ORTHOPEDIC MANUFACTURERS AND
SUPPLIERS, 2013 (NUMBER) 47
MEDICAL TOURISM IMPACT ON THE ORTHOPEDIC MARKET 48
TABLE 15 HIP REPLACEMENT: GLOBAL COST VARIATIONS, 2008 DATA ($
MILLIONS/NUMBER) 49
FIGURE 4 HIP REPLACEMENT: GLOBAL COST VARIATIONS ($ MILLIONS/NUMBER) 49
TABLE 16 U.S. HEALTH INSURANCE COVERAGE BY AGE GROUP (%) 50
FIGURE 5 U.S. HEALTH INSURANCE COVERAGE BY AGE GROUP (%) 51
PUBLIC HEALTHCARE SYSTEMS AROUND THE WORLD 51
TABLE 17 WORLD HEALTH ORGANIZATION RANKING OF HEALTHCARE SYSTEMS,
TOP 50, 2000 52
DEMOGRAPHICS AND AGING POPULATIONS 53
Global Demographics 53
TABLE 18 ESTIMATED WORLD POPULATION BY SELECTED AGE GROUP AND
SELECTED YEARS, THROUGH 2030 (MILLIONS) 54
FIGURE 6 ESTIMATED WORLD POPULATION BY SELECTED AGE GROUP AND
SELECTED YEARS, 2000-2030 ($ MILLIONS) 54
TABLE 19 GLOBAL POPULATION BY SELECTED COUNTRY, THROUGH 2015
(MILLIONS) 55
FIGURE 7 GLOBAL POPULATION BY SELECTED COUNTRY, 2010 AND PROJECTED
2015 (MILLIONS) 55
U.S. Demographics 56
TABLE 20 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP
1900-2050 (THOUSANDS) 56
FIGURE 8 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP,
1900-2050 (THOUSANDS) 56
Gender, Age and Life Expectancy 57
TABLE 21 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH
PROJECTIONS BY GENDER, 2000 AND 2020 (YEARS) 57
FIGURE 9 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH
PROJECTIONS BY GENDER, 2000 AND 2020 (YEARS) 57
TABLE 22 GLOBAL LIFE EXPECTANCY AT BIRTH BY SELECTED COUNTRY, 1980 AND
2013 (YEARS) 58
FIGURE 10 GLOBAL LIFE EXPECTANCY AT BIRTH BY SELECTED COUNTRY, 1980
AND 2013 (YEARS) 59
INCIDENCE OF ORTHOPEDIC CONDITIONS 59
Osteoarthritis 59
Rheumatoid Arthritis 60
Ankylosing Spondylitis 60
Fibromyalgia 60
Gout 60
Scleroderma 61
Lupus 61
Bursitis and Tendonitis 61
Osteoporosis 61
Low Bone Mass 62
TABLE 23 ESTIMATED* PREVALENCE/INCIDENCE OF CONDITIONS AFFECTING THE
GLOBAL ORTHOPEDIC INDUSTRY, AVERAGE FIGURE, 2010-2013 (MILLIONS) 62
FIGURE 11 ESTIMATED* PREVALENCE/INCIDENCE OF CONDITIONS AFFECTING THE
GLOBAL ORTHOPEDIC INDUSTRY, AVERAGE FIGURE, 2010-2013 (MILLIONS) 62
ORTHOPEDIC PROCEDURE VOLUMES IN THE U.S. 63
FIGURE 12 NUMBER OF U.S. HIP REPLACEMENT PROCEDURES, 2000-2013
(NUMBER) 63
FIGURE 13 NUMBER OF U.S. KNEE REPLACEMENT PROCEDURES, 2000-2013
(NUMBER) 64
FIGURE 14 NUMBER OF U.S. SPINAL FUSION PROCEDURES, 2000-2013 (NUMBER) 65
FIGURE 15 NUMBER OF U.S. PHYSICIAN VISITS FOR ROTATOR CUFF PROBLEMS,
2000-2013 (MILLIONS) 66
RISING ORTHOPEDIC INCIDENCE AND EVOLVING LIFESTYLE TRENDS 66
Overweight and Obesity 66
TABLE 24 U.S. AGE-ADJUSTED PERCENT DISTRIBUTION OF BODY MASS INDEX (BMI)
AMONG PERSONS, 18 YEARS AND OVER, BY SELECTED CHARACTERISTICS 67
FIGURE 16 OBESITY BY COUNTRY (%) 67
Smoking 69
TABLE 25 PERCENT OF SMOKERS IN THE U.S. POPULATION, 18 AND OLDER, BY
AGE AND GENDER, 2009 (%) 69
TABLE 26 DAILY TOBACCO CONSUMPTION BY COUNTRY: 1990 COMPARED TO
2009* (TOTAL % SMOKERS) 71
FIGURE 17 DAILY TOBACCO CONSUMPTION BY COUNTRY: 1990 COMPARED TO
2009* (TOTAL % SMOKERS) 71
Sedentary Lifestyle 72
TABLE 27 PERCENT OF U.S. ADULTS ENGAGING IN PHYSICAL ACTIVITY AND
FITNESS BY SELECTED CHARACTERISTICS, 2008 (%) 73
Nutrition 73
COMPARISON OF BONE MINERAL DENSITY LEVELS IN POPULATIONS 73
CHAPTER 5 TECHNOLOGY 76
INTRODUCTION 76
PATENT TRENDS 76
ORTHOPEDIC PATENTS BY YEAR 76
TABLE 28 NUMBER OF ORTHOPEDIC PATENTS ISSUED BY YEAR, 1995-2014* 77
FIGURE 18 NUMBER OF ORTHOPEDIC PATENTS ISSUED BY YEAR, 1995-2014* 77
INTERNATIONAL PATENTS BY COUNTRY OF ORIGIN 77
TABLE 29 ORTHOPEDIC PATENTS BY COUNTRY OF ORIGIN, 1976-2014* (NO. OF
PATENTS) 78
FIGURE 19 ORTHOPEDIC PATENTS BY COUNTRY OF ORIGIN, 1976-2014* (NO. OF
PATENTS) 78
PATENT TRENDS BY ASSIGNEE 79
TABLE 30 ADVANCED ORTHOPEDIC PATENT INFORMATION BY ASSIGNEE 80
Biomet 83
ConMed 83
DePuy 83
DJO Surgical 84
Exactech 84
Medtronic 84
Smith & Nephew 84
Stryker 85
Synthes 85
Warsaw Orthopedic 86
Wright Medical 86
Zimmer Holdings 86
ADVANCED ORTHOPEDIC TECHNOLOGIES 87
Bone-Growth Stimulation Devices 87
Orthopedic Growth Factors 88
Transcutaneous Electrical Nerve Stimulation Units 88
Light Therapy (Light-Emitting Diodes and Infrared) 88
Thermal Imaging 90
Nanotechnology and Microprocessors 90
Digital X-rays 90
Bone Density Improvements 91
High-resolution Cartilage Imaging 91
Stem Cells 91
Government Limitations 92
Embryonic Stem Cells 92
Adult Stem Cells 92
Bone Technology and Stem Cells 93
Synthetic Bone Grafting 93
Bone Modeling for Osteoporotic Spinal Fracture Testing 93
Advanced Mechanical Implant Creation 93
CHAPTER 6 BONE REPAIR AND REGENERATIVE PRODUCTS 96
SEGMENT OVERVIEW 96
BONE GRAFTS 96
TABLE 31 BONE GRAFT PRODUCTS AND MATERIALS 97
Procedures Using Bone Grafts 98
PRODUCT DESCRIPTIONS 98
HUMAN BONE PRODUCTS 98
TABLE 32 HUMAN BONE PRODUCTS AND COMPETITORS 98
Biomet 99
DePuy 100
Exactech 100
Integra Life Sciences 100
LifeCell Inc. 101
Medtronic 101
Orthofix 101
Wright Medical 102
Zimmer Holdings 102
BONE-GROWTH STIMULATORS 102
TABLE 33 BONE-GROWTH STIMULATOR (BIOLOGICAL) PRODUCTS AND
COMPETITORS 103
TABLE 34 BONE-GROWTH STIMULATOR (ELECTRICAL/ULTRASOUND DEVICES)
PRODUCTS AND COMPETITORS 103
Biomet 103
Bioventus 104
DJO Global 104
Medtronic 104
NuVasive 105
Orthofix International 106
Stryker 106
SYNTHETIC BONE REPLACEMENTS 107
TABLE 35 SYNTHETIC BONE-REPLACEMENT PRODUCTS AND COMPETITORS 107
Baxter 108
Biomet 108
DePuy Synthes 108
Exactech 109
Integra Life Sciences 109
Medtronic 109
Orthofix 109
Smith & Nephew 109
Stryker 109
Wright Medical 110
Zimmer Holdings 110
MARKET ANALYSIS 110
MARKETS BY PRODUCT TYPE 111
TABLE 36 BONE REPAIR AND REGENERATIVE PRODUCTS MARKET, THROUGH 2019
($ MILLIONS) 112
FIGURE 20 BONE REPAIR AND REGENERATIVE PRODUCTS MARKET 2010-2019 ($
MILLIONS) 112
SALES DISTRIBUTION BY PROCEDURE TYPE 113
TABLE 37 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE
PRODUCTS BY PROCEDURE TYPE, 2014 ($ MILLIONS) 113
FIGURE 21 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE
PRODUCTS BY PROCEDURE TYPE, 2014 ($ MILLIONS) 114
MARKETS BY REGION 114
TABLE 38 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE
PRODUCTS BY REGION, 2014 (%) 115
FIGURE 22 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE
PRODUCTS BY REGION, 2014 (%) 115
LEADING SUPPLIERS AND PARTICIPANTS 116
TABLE 39 SUMMARY OF BONE REPAIR AND REGENERATIVE PRODUCTS BY
COMPETITOR REVENUES, 2014 ($ MILLIONS) 117
FIGURE 23 SUMMARY OF BONE REPAIR AND REGENERATIVE PRODUCTS BY
COMPETITOR REVENUES, 2014 ($ MILLIONS) 117
CHAPTER 7 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE
PRODUCTS 120
SEGMENT OVERVIEW 120
PRODUCT DESCRIPTIONS 121
FIXATION SYSTEMS AND OTHER SPECIALIZED DEVICES 121
TABLE 40 FIXATION SYSTEMS AND OTHER SPECIALIZED DEVICES AND MARKETERS 121
Arthrex 122
ArthroCare 123
Biomet 123
Conmed Linvatec 123
Corin Group 124
Covidien 124
DePuy Synthes 124
Integra Life Sciences 124
Ortheon Medical 125
Smith & Nephew 125
Stryker 125
Zimmer Holdings 125
BIOLOGICS AND BIOMATERIALS 125
TABLE 41 CARTILAGE AND SOFT TISSUE BIOLOGICS AND BIOMATERIALS SEGMENT 126
Aesculap 126
Biomet 126
DePuy 126
Integra Life Sciences 127
LifeCell Inc. 127
Sanofi 127
Stryker 127
Wright Medical 127
Zimmer Holdings 128
MARKET ANALYSIS 128
MARKETS BY PRODUCT TYPE 128
TABLE 42 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE
PRODUCTS MARKET, THROUGH 2019 ($ MILLIONS) 130
FIGURE 24 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE
PRODUCTS MARKET, 2010-2019 ($ MILLIONS) 130
MARKETS BY REGION 130
TABLE 43 GLOBAL DISTRIBUTION OF REVENUES FROM CARTILAGE AND OTHER
SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS BY REGION, 2014 (%/$
MILLIONS)
131
FIGURE 25 GLOBAL DISTRIBUTION OF REVENUES FROM CARTILAGE AND OTHER
SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS BY REGION, 2014 (%) 132
LEADING SUPPLIERS AND PARTICIPANTS 132
TABLE 44 SUMMARY OF CARTILAGE AND OTHER SOFT TISSUE REPAIR AND
REGENERATIVE PRODUCTS BY COMPETITOR REVENUES, 2014 (%/$ MILLIONS) 133
FIGURE 26 SUMMARY OF CARTILAGE AND OTHER SOFT TISSUE REPAIR AND
REGENERATIVE PRODUCTS BY COMPETITOR REVENUES, 2014 ($ MILLIONS) 134
CHAPTER 8 JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS 136
SEGMENT OVERVIEW 136
PRODUCT DESCRIPTION 138
HIP REPLACEMENTS 138
TABLE 45 HIP REPLACEMENT PRODUCT SUPPLIERS 138
Biomet 139
DePuy Synthes 139
DJO Global 140
Exactech 140
MicroPort Scientific Corp. 141
Smith & Nephew 141
Stryker 141
Zimmer Holdings 142
KNEE REPLACEMENTS 142
TABLE 46 KNEE REPLACEMENT PRODUCT SUPPLIERS 143
Biomet 143
DePuy Synthes 143
DJO Global 144
Exactech 144
MicroPort Scientific Corp. 144
Smith & Nephew 144
Stryker 145
Zimmer Holdings 145
SPINE REPLACEMENTS/FIXATION 146
TABLE 47 SPINE REPLACEMENT/FIXATION PRODUCT SUPPLIERS 146
Aesculap 147
Alphatec 147
Biomet Spine 147
DePuy Synthes Spine 148
Exactech 149
Globus Medical 149
Integra Life Sciences (Integra Spine) 149
LDR Spine 150
Medtronic 150
MicroPort Scientific Corp. 151
Orthofix International 151
Stryker 152
Zimmer Holdings 152
OTHER EXTREMITY REPLACEMENTS AND JOINT PRODUCTS 153
TABLE 48 OTHER EXTREMITY REPLACEMENTS, JOINT PRODUCT SUPPLIERS 153
Biomet 154
DePuy Synthes 154
DJO Global 155
Exactech 155
Small Bone Innovations 155
Stryker 155
Wright Medical 155
Zimmer Holdings 156
BIOLOGICAL JOINT PRODUCTS AND OTHER RELATED DEVICES 156
TABLE 49 BIOLOGICAL JOINT PRODUCTS AND OTHER RELATED DEVICES 157
Anika Therapeutics 157
Bioventus 157
Ferring Pharmaceuticals 158
Institut Biochimique SA 158
Mylan 158
Sanofi 159
Zimmer Holdings 159
MARKET ANALYSIS 159
MARKETS BY PRODUCT TYPE 160
TABLE 50 JOINT REPLACEMENT, IMPLANT AND REGENERATIVE PRODUCT MARKETS,
THROUGH 2019 ($ MILLIONS) 161
FIGURE 27 JOINT REPLACEMENT, IMPLANT AND REGENERATIVE PRODUCT
MARKETS, 2010-2019 ($ MILLIONS) 162
MARKETS BY REGIONS 162
TABLE 51 GLOBAL REVENUE DISTRIBUTION FOR JOINT REPLACEMENTS, IMPLANTS
AND REGENERATIVE PRODUCTS, 2014 (%/$ MILLIONS) 163
FIGURE 28 GLOBAL REVENUE DISTRIBUTION FOR JOINT REPLACEMENTS, IMPLANTS
AND REGENERATIVE PRODUCTS, 2014 (%) 163
LEADING SUPPLIERS AND PARTICIPANTS 163
TABLE 52 SUMMARY OF JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE
PRODUCTS BY COMPETITOR REVENUES, 2014 (%/$ MILLIONS) 165
FIGURE 29 SUMMARY OF JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE
PRODUCTS BY COMPETITOR REVENUES, 2014 ($ MILLIONS) 166
CHAPTER 9 MARKET SUMMARY 168
GLOBAL MARKET ANALYSIS 168
TABLE 53 GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT,
THROUGH 2019 ($ MILLIONS) 168
FIGURE 30 GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT
SEGMENT, THROUGH 2019 ($ MILLIONS) 169
GEOGRAPHIC MARKET ANALYSIS 169
TABLE 54 GLOBAL ADVANCED ORTHOPEDIC PRODUCT REVENUE DISTRIBUTION BY
REGION, 2014 ($ MILLIONS) 170
FIGURE 31 GLOBAL ADVANCED ORTHOPEDIC PRODUCT REVENUE DISTRIBUTION
BY REGION, 2014 ($ MILLIONS) 170
INDUSTRY PARTICIPANTS 171
TABLE 55 ADVANCED ORTHOPEDIC TECHNOLOGY INDUSTRY PARTICIPANTS BY
TYPE, 2013-2014 171
TABLE 56 ADVANCED ORTHOPEDIC COMPETITORS' MARKET SHARE ESTIMATES,
2014 (%/$ BILLIONS) 174
FIGURE 32 DISTRIBUTION OF SALES BY COMPETITOR, 2014 ($ BILLIONS) 174
CHAPTER 10 COMPANY PROFILES 176
INTRODUCTION 176
CHAPTER 11 APPENDIX: LEADING PRODUCT MANUFACTURERS 189
LEADING PRODUCT MANUFACTURERS 189

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