2014

Aeterna Zentaris: Posters to be Presented on Phase 1 and Phase 2 Trials with AEZS-108 in Prostate and Breast Cancer at Upcoming ASCO Meeting

QUÉBEC CITY, May 23, 2013 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZ) (the "Company") today announced that the following posters will be presented on AEZS-108, the Company's lead oncology compound, at the upcoming American Society of Clinical Oncology ("ASCO") annual meeting, which will be held May 31 to June 4, 2013, in Chicago.

Abstract # 5062:  "A Phase 1 Dose Escalating Trial of AEZS-108 in Taxane- and Castration-Resistant Prostate Cancer", J. Pinski, A.V. Schally, D. Tsao-Wei, T.B. Dorff, S. Groshen, S. Xiong, D. Quinn, Y. Tai, J. Engel, S.V. Liu.
Presenter:  Jacek Pinski, MD, PhD, USC Norris Comprehensive Cancer Center, California
Date & Time:  Monday, June 3, 2013, from 8:00 am to 11:45 am (central)
Venue:  S Hall 2, McCormick Place, Chicago

Abstract # TPS 11124:  "A Randomized Phase 2 Trial of AEZS-108 in Chemotherapy Refractory Triple-Negative (ER/PR/HER2-Negative) LHRH-R Positive Metastatic Breast Cancer", S. Buchholz, J.B. Engel, A.V. Schally, S. Seitz, O. Ortmann, G. Emons, R.L. Mahtani, S. Glück, C. Vogel, A.J. Montero.
Presenter:  Stefan Buchholz, MD, Medical Center University of Regensburg, Germany
Date & Time:  Monday, June 3, 2013, from 1:15 pm to 5:00 pm (central)
Venue:  S Hall 2, McCormick Place, Chicago

A third abstract (# e15596) on AEZS-108, "A Case Report of a Long-Term Response in a Patient with Urothelial Cancer (UC) Treated with AEZS-108", G. L. Fernandez, A. V. Schally, T. Koru-Sengul, M. Jorda, J. R. Merchan, A. M. Flores, N. L. Block, M. Manoharan, J. Engel, is currently available online on ASCO's website, but will not be presented during a poster session. The abstract reports on the first patient with LHRH-R positive UC treated with AEZS-108 in an ongoing Phase 1 clinical trial.

About AEZS-108 (doxorubicin peptide conjugate)

AEZS-108 represents a new targeting concept in oncology using a hybrid molecule composed of a synthetic peptide carrier and a well-known chemotherapy agent, doxorubicin. AEZS-108 is the first intravenous drug in advanced clinical development that directs the chemotherapy agent specifically to LHRH-receptor expressing tumors, resulting in more targeted treatment with less damage to healthy tissue. The product has successfully completed Phase 2 studies for the treatment of ovarian and endometrial cancer and the Company is currently initiating a Phase 3 trial in endometrial cancer under a Special Protocol Assessment. AEZS-108 is also in Phase 2 trials in triple-negative breast cancer, prostate cancer and bladder cancer. AEZS-108 has been granted orphan drug designation by the FDA and orphan medicinal product designation from the European Medicines Agency for the treatment of ovarian cancer. Aeterna Zentaris owns worldwide rights to AEZS-108.

About Aeterna Zentaris

Aeterna Zentaris is an oncology and endocrinology drug development company currently investigating treatments for various unmet medical needs. The Company's pipeline encompasses compounds at all stages of development, from drug discovery through to marketed products. For more information, visit www.aezsinc.com.

 

SOURCE Aeterna Zentaris Inc.




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