WOONSOCKET, R.I., Dec. 26, 2012 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET) presented at the 2012 American Society for Cell Biology® (ASCB®) Annual Meeting in San Francisco, CA, on Tuesday, December 18. Simona Bot, M.D. presented preclinical research results in an abstract titled "Short Synthetic Double Stranded RNA with Dual Activity - Oncolytic and Immune Modulatory - for Hepatocellular Carcinoma."
This research was supported by MultiCell via a sponsored research grant with the laboratory of Anand Ghanekar, M.D., Ph.D. at University Health Network, Toronto General Hospital Research Institute, Ontario, Canada. The scientific results presented by Dr. Bot added key information regarding the capability of MCT-485 to elicit highly pro-inflammatory cytokine by human monocytes, and death of human liver cancer cells, mostly through a mechanism distinct from apoptosis. Together with the data previously presented at the Association of Cancer Immunotherapy (CIMT annual meeting, May 2012, Mainz, Germany) describing the direct anti-tumor cell effect of MCT-485 on multiple human liver cancer cell lines in vitro, the novel scientific evidence supports the model that this synthetic dsRNA molecule could mediate a two-pronged effect within the tumor environment: destruction of the tumor cells and activation of the stromal monocytes. The latter could amplify the immune system's capability to fight off tumor over a longer timeframe.
Altogether, these data sets, generated for the first time with MCT-485 manufactured using a state of the art process, as presented at CIMT and ASCB® 2012, support further studies exploring the preclinical safety, effectiveness and clinical utility of this candidate as a novel therapeutic agent for hepatocellular carcinoma.
About MultiCell Technologies, Inc. MultiCell Technologies, Inc. is a clinical-stage biopharmaceutical company developing novel therapeutics and discovery tools that address unmet medical needs for the treatment of neurological disorders, hepatic disease and cancer. For more information about MultiCell Technologies, please visit http://www.multicelltech.com. For more detailed background on the presentation refer to the September 27 news release, and the poster archived on the site.
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SOURCE MultiCell Technologies, Inc.