Nanotechnology for Drug Delivery: Global Market for Nanocrystals

NEW YORK, March 21, 2012  /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Nanotechnology for Drug Delivery: Global Market for Nanocrystals

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Nanocrystals will account for 60% of a $136 billion nanotechnology-enabled drug delivery market by 2021. We forecast the total market size in 2021 to be US$136 billion, with a 60/40 split between nanocrystals and nanocarriers respectively.

Since we now understand that most (if not all) biological processes occur at the nanoscale, the application of life science principles – studying the causes of biological phenomena at the molecular level – means that medical and biomedical research is increasingly using a bottom-up (rather than the top-down) approach.

One of the biggest challenges researchers face when developing a new drug is how to maximise its solubility in the body. Poor solubility in water correlates with poor bioavailability, which in turn leads to poor delivery. Nanocrystals are ground in special mills producing nano-sized drugs, which are applicable intravenously as nanosuspensions. This procedure enhances the surface/volume-ratio and thus the solubility and bioavailability of most insoluble pharmaceuticals.

The low bioavailability resulting from traditional oral and intravenous drug delivery methods and the market forces at work in the pharmaceutical industry – where patents expire after a relatively short period of time unless a novel form of drug delivery is developed that will extend the patent – are two major forces that will fuel the growth of the nano tech enabled drug delivery market.

The healthcare market is changing. We are seeing a paradigm shift away from blockbusters and a 'one-size fits all' approach to a more personalised medicine based on an individual's unique genome and immune response. The more scientists learn about the molecular causes for disease the more targeted and effective nanotechnology-enabled drug delivery therapies will become.

Table of Contents Table of Exhibits 6

EXECUTIVE SUMMARY 10

CHAPTER 1 - INTRODUCTION 15

REPORT SCOPE 15

METHODOLOGY 15

Procurement 16

Calculation of CAGR 16

THE NANOSCALE 18

Two biological examples that illustrate nanoscale: 18

CHAPTER 2 – NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE 20

OVERVIEW OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE 20

Why is Nanotechnology A Critical Application for Medicine and Biomedicine? 20

Why Nanotechnology Is Needed for Medicine and Biomedicine 22

WHAT ARE THE KEY DRIVERS FOR ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND

BIOMEDICINE? 25

The Aim Of Drug Targeting 25

Rapid Market Growth 26

Market Drivers For Enhanced Drug Delivery 26

Increasing Proportion of The Ageing Population 27

Demand For More Affordable Health Care 29

Public Health – Ending disease 29

Demand for More Innovation 29

Social responsibility 29

THE KEY APPLICATIONS OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE 30

How Nanotechnology Can Benefit Drug Delivery 31

Nanotechnology in Medical and Biomedical Diagnostics 32

Nanotechnology in Regenerative Medicine and Tissue Engineering 32

Other Applications For Nanomaterials In The Medical And Pharmaceutical Sector 32

PROMISING EXAMPLES OF NANOTECHNOLOGY ENABLED DRUG DELIVERY 33

Case Study 1 – Magnetic Field Acts as "Remote Control" to Deliver Nanomedicine 33

Case Study 2 - Adaptive Micro and Nanoparticles: Temporal Control Over Carrier

Properties to Facilitate Drug Delivery 34

Case Study 3 – Fabrication of a Nanocarrier System Through Self-Assembly of Plasma

Protein And Its Tumour Targeting 37

Case Study 4 – IBM And The Institute of Bioengineering And Nanotechnology Find

Breakthrough For MRSA 37

CHAPTER 3 – RISK & REGULATION 41

THREE KEY BARRIERS TO THE ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND

BIOMEDICINE 41

Nanotoxicity, Nanopollution and Nanosafety 41

Ethical Considerations Of Nanotherapies 43

Delayed Nanoregulation 44

FIVE CURRENT & FUTURE CHALLENGES IN THE ADOPTION OF NANOTECHNOLOGY IN

MEDICINE AND BIOMEDICINE 46

Current & Future Challenges of Nanosafety And Risk Management 46

Current & Future Challenges of Nanoregulation 49

Current & Future Challenges for the Nanomedicine Industry 51

Current & Future Challenges of Sustained Innovation 52

Current & Future Challenges of Cooperation 52

CHAPTER 4 – MARKET FOR NANOCRYSTALS 55

GLOBAL NDD MARKET ANALYSIS: 2000-2010 55

GLOBAL NDD MARKET FORECAST: 2011-2021 58

DISCUSSION OF NANOPARTICLES AND NANOCRYSTALS 61

Overview of The Key Nanotechnologies Used in Drug Delivery Sorted by Applications 61

Nanopharmaceuticals 61

Nanotechnology In Drug Delivery 61

Nanobiotechnology In Drug Delivery 62

Analytical Techniques For Nanoparticle Drug Delivery 63

Properties 63

Production of Nanoparticles 63

Measuring Dispersion of Nanoparticles 64

Characterisation of Delivery Systems 65

What Can Nanoparticles do in Drug Delivery? 66

Drug Nanocrystals: Nanosizing The Drugs 67

Clinically Approved Nanocrystals-Based Drug Formulations With Presence on The Market

Production methods 70

Projected Product Pipeline For Nanocrystals-Based Drug Formulations In Drug Delivery

Market 70

Semapimod® (cytokine, pharmasciences) 72

Paxceed™ 72

Theralux™ 73

Nucryst® 73

iSPERSE™ 74

ANALYSIS OF TAM FOR NANOCRYSTALS: 2000-2010 76

TAM FORECAST FOR NANOCRYSTALS: 2011-2021 81

APPENDIX 88

PUBLISHING ACTIVITY BY ORGANIZATION (2000-2010) 88

Table of Exhibits Exhibit 1.1

Formula for the calculation of the Compound Annual Growth Rate (CAGR), (top).

Formula for the calculation of the Compound Annual Growth Rate (CAGR) in this report, for the 2011-2021

period, (bottom) [2].

Exhibit 1.2

Formula for the verification of the calculated values of the Compound Annual Growth Rate (CAGR), (top).

Formula for the verification of the calculated values of the Compound Annual Growth Rate (CAGR) in this

report, for the 2011-2021 period, (bottom) [2].

Exhibit 1.3

Nanometers in a meter (top). Meters in a nanometer (bottom).

Exhibit 2.1

Illustration of the fact that the periodic table of elements, as we know it (at meter scale) governed by classic

Newtonian laws of physics. However, when perceived at nanoscale, those elements are governed by the laws

of quantum physics.

Exhibit 2.2

Proportion of the population aged over 65 and over 80 [7].

Exhibit 2.3

Illustration of a diagram of each property of nanocarriers (size, shape, surface chemistry and mechanical

properties) and their parameters subjected to optimization in order to improve their efficiency [10].

Exhibit 3.1

Specified expected barriers in the development of particular types of nanoparticles (Courtesy of

CienNanoroadmap Synthesis Report), [6].

Exhibit 3.2

Illustration of the measures adoption roadmap to combat/attenuate the key barriers to the adoption of

nanotechnology in medicine and biomedicine (Source: Cientifica, Ltd.).

Exhibit 3.3

Table representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery,

without segmentation, source: Cientifica (all figures US$ Million Dollars).

Exhibit 3.4

Line chart representing Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery,

without segmentation, source: Cientifica (all figures US$ Million Dollars).

Exhibit 3.5

Bar chart representing Total Addressable Market, TAM (2000-2010), for nanotechnology in drug delivery,

without segmentation, source: Cientifica (all figures US$ Million Dollars).

Exhibit 3.6

Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for

nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).

Exhibit 3.7

Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for

nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).

Exhibit 3.8

Bar chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for

nanotechnology in drug delivery, without segmentation, source: Cientifica (all figures US$ Million Dollars).

Exhibit 4.1

Typical Image of Colloidal Gold Nanoparticles [1].

Exhibit 4.26

Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for

nanocrystals, source: Cientifica (all figures US$ Million Dollars).

Exhibit 4.4

Advantages and disadvantages of different methods for the production of drug nanocrystals [6].

Exhibit 4.67

Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for

nanocrystals, source: Cientifica (all figures US$ Million Dollars).

Exhibit 4.7

Representative examples of clinically approved nanocrystals-based drug formulations with presence on the

market [6]

Exhibit 4.37

3-D pie chart representing the Total Addressable Market, TAM in 2010, for nanotechnology in drug delivery,

nanocarriers versus drug nanocrystals, source: Cientifica (all figures in percentage).

Exhibit 4.38

Line chart representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in drug

delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).

Exhibit 4.39

3-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010) , for

nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$

Million Dollars).

Exhibit 4.40

3-D stacked area chart representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in

drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).

Exhibit 4.45

In vivo effects of nanocrystals-based drug formulations [6].

Exhibit 4.78

3-D pie chart representing the Total Addressable Market, TAM forecast in 2021, for nanotechnology in drug

delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures in percentage).

Exhibit 4.79

Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021, for nanotechnology

in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$ Million Dollars).

Exhibit 4.80

Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for

nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all figures US$

Million Dollars).

3-D stacked vertical bar graph representing the Total Addressable Market, TAM forecast by 2021 (for the

2011-2021 period), for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source:

Cientifica (all figures US$ Million Dollars).

Exhibit 4.82

3-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021

period), for nanotechnology in drug delivery, nanocarriers versus drug nanocrystals, source: Cientifica (all

figures US$ Million Dollars).

Appendix

Exhibit A.1

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: North America; country: USA.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.2

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: European Union; country:

Germany.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.3

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: European Union; country: France.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.4

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: European Union; country: UK.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.5

Table of publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in

Drug Delivery. Country: Russian Federation.

Organizations are ordered alphabetically (increasing order).

Exhibit A.6

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: India.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.7

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: India.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.8

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: Japan.

Científica

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: P R China.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.10

Table of the top 20 organizations showing the highest publishing activity in PubMed periodicals (2000-2010),

based on PubMed, for Nanotechnology in Drug Delivery. World Region: Asia; country: South Korea

(Republic of Korea).

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

Exhibit A.11

Table of publishing activity in PubMed periodicals (2000-2010), based on PubMed, for Nanotechnology in

Drug Delivery. Asia; country: Taiwan.

Organizations are ordered first by descending order of total articles published and then ordered alphabetically

(increasing order), if applicable.

To order this report:Drug Delivery Technology Industry: Nanotechnology for Drug Delivery: Global Market for Nanocrystals

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