PharmaMar Shows New Clinical Data on Yondelis® and Lurbinectedin at ESMO 2016

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MADRID, October 5, 2016 /PRNewswire/ --

• During this congress, PharmaMar will inform in an oral session the results of its Phase II clinical trial with lurbinectedin in patients with BRCA 1/2 metastatic breast cancer 
  
• A prospective randomized phase III comparing trabectedin versus the best supportive care in patients with pretreated advanced soft tissue sarcoma(T-SAR trial) will be presented in an oral session by the French Sarcoma Group 

PharmaMar (MCE:PHM) will present the data obtained from various clinical trials carried out with its antitumoral compounds of marine origin: Yondelis^® (trabectedin) and lurbinectedin (PM1183), at the European Society of Medical Oncology (ESMO) congress that will take place in Copenhagen (Denmark), from the 7^th to the 11^th of October.  

     (Logo: http://photos.prnewswire.com/prnh/20150203/727958-b )

During this congress, PharmaMar will participate at different posters sessions and/or oral presentations the latest clinical advances of these molecules. In this edition, PharmaMar will present, among others, the results of a single-agent (lurbinectedin) Phase II trial in patients with BRCA 1/2 -associated metastatic breast cancer. Moreover, the French Sarcoma Group will introduce the data from a Phase III prospective study carried out in France (T-SAR), which compares trabectedin versus the best supportive care in patients with pretreated advanced soft tissue sarcoma (ASTS).

"At this year's edition of ESMO, we will announce the latest breakthroughs obtained with lurbinectedin in different tumor types. Through the various clinical trials that PharmaMar has running, we can observe that PM1883 is effective in combination and also as single-agent. This allows us to think that we have a great molecule for the treatment of different types of solid tumors, such as breast and endometrial cancers, amongst others", as Dr. Arturo Soto, director of Clinical Development at PharmaMar´s Oncology Business Unit, explains.            

The trials that will be presented during this congress are available on https://cslide.ctimeetingtech.com/library/esmo/browse/search

Highlighted studies at ESMO 2016  

Yondelis^® (trabectedin)  

• Results of a prospective randomized phase III T-SAR trial comparing trabectedin vs. best supportive care (BSC) in patients with pretreated advanced soft tissue sarcoma (ASTS) (Abstract #1473). Conducted by The French Sarcoma Group 
  Proffered paper (Oral presentation). Saturday, October 8^th from 11:00 a.m. to 12:15 p.m. Brussels
  Lead author: Axel Le Cesne, MD, et al. Institut de Cancérologie Gustave Roussy, Villejuif, France
  
• Update of the T-DIS randomized phase II trial: trabectedin rechallenge versus continuation in patients with advanced soft tissue sarcoma (Abstract #2368). Conducted by the French Sarcoma Group  Poster. Monday, October 10^th from 13:00 to 14:00 p.m. Hall E.
  Lead author: Nuria Kotecki, MD et al. Centre Oscar Lambret, Lille, France

Lurbinectedin (PM1183) 

• Anti-tumor activity of PM1183 (lurbinectedin) in BRCA 1/2-associated metastatic breast cancer patients: results of a single-agent phase II trial (Abstract #2333) 
  Proffered paper (Oral presentation). Saturday, October 8^th from 11:00 to 12:30 p.m. Vienna
  Lead author: Judith Balmaña, MD, et al. Vall d´Hebron University Hospital and Vall d´Hebron Institute of Oncology, Barcelona, Spain.
  
• Phase Ib/II study to evaluate the efficacy and tolerability of PM01183 (lurbinectedin) in combination with olaparib in patients with advanced solid tumors (Abstract #3654) 
  Poster. Saturday, October 8^th from 13:00 a 14:00 p.m. Hall E.
  Lead author: Andrés Poveda, MD, et al. Valencia Institute of Oncology. Spain.
  
• Lurbinectedin (PM01183) exhibits antitumor activity in PARP-inhibitor resistant germline BRCA PDX and lacks cross-resistance with cisplatin (Abstract # 3003) 
  Proffered paper (Oral presentation). Saturday, October 8^th from 11:00 to 12:30 p.m. Madrid
  Lead author: Cristina Cruz, MD, et al. Vall d´Hebron University Hospital and Vall d´Hebron Institute of Oncology, Barcelona, Spain.
  
• Lurbinectedin (PM1183) plus Paclitaxel (P), Recommended Dose (RD) Expansion Results with or without the addition of Bervacizumab (Bev) in patients with selected solid tumors (Abstract #1814) 
  Poster. Monday, October 10^th from 13:00 to 14:00 p.m. Hall E.
  Lead author: A. Drilon, MD, et al. Memorial Sloan Kettering Cancer Centre, New York, USA.
  
• Lurbinectedin (PM1183) administered once every 3 weeks in combination with capecitabine in patients with metastatic breast, colorectal or pancreatic cancer (Abstract #2310)Poster. Monday, October 10^th from 13:00 to 14:00 p.m. Hall E.
  Lead author: T. Sauri, MD, et al. Vall d´Hebron University Hospital and Vall d´Hebron Institute of Oncology, Barcelona, Spain.

Paula Fernández, Media Relations +34 638 79 62 15 and Investor Relations (+34 914444500)

SOURCE PharmaMar