"Our team's extraordinary efforts have allowed us to initiate our first clinical study less than a year after spinning out our company and platform from Naurex," said Norbert Riedel, Ph.D., president and chief executive officer of Aptinyx. "As we conduct this study, we will also finalize the selection of one or more specific indications for Phase 2 studies of NYX-2925. We have seen compelling evidence of efficacy for NYX-2925 in preclinical models of multiple neurologic conditions, and will move forward in the disease areas in which we believe we can have the greatest potential therapeutic impact."
Aptinyx's chemistry and discovery platform is yielding numerous additional small-molecule modulators of the NMDA receptor, which are currently in preclinical development. The company's compounds are designed to enhance synaptic plasticity — or strengthen the network for neural cell communication — a clinically validated mechanism with therapeutic potential across multiple nervous system conditions.
Aptinyx Inc. is a biopharmaceutical company focused on discovery and development of transformative therapies for challenging neurologic disorders. Aptinyx has a proven platform for discovering compounds that enhance synaptic plasticity, or strengthen the network for neural cell communication. Molecules discovered by Aptinyx achieve this through a novel mechanism that modulates NMDA receptors, resulting in drugs that are both highly effective and well tolerated. This mechanism has applicability across a number of disorders of the brain and nervous system. For more information, visit www.aptinyx.com.
Logo - http://photos.prnewswire.com/prnh/20150915/266968LOGO
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/aptinyx-initiates-dosing-in-phase-1-clinical-study-of-lead-nmda-receptor-modulator-nyx-2925-300297726.html
SOURCE Aptinyx Inc.