Biologic Therapeutic Drugs: Technologies and Global Markets
NEW YORK, Jan. 8, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Biologic Therapeutic Drugs: Technologies and Global Markets
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INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY SCOPE OF REPORTFor example, the trend of increased use of vascular endothelial growth factor (VEGF) inhibitors as a first-line therapy for multiple disease states such as colorectal cancer and the ophthalmic disease wet age-related macular degeneration (AMD) are discussed.The report includes analysis of leading and emerging competitors in the current worldwide market. Profiles of manufacturers of leading products as well as biotechnology companies with novel products in development are analyzed to define their specific product strategies employed. This report also assesses companies poised to introduce products during the forecast period and discusses how these introductions will change the face of the competitive environment. The competitive environment is examined with a special focus on how new products and technologies are influencing the current standard of care. Detailed profiles of current market leaders are discussed, as well as companies with innovative products poised to advance within the forecast period.Market figures are based on revenues at the manufacturers' level and are projected at 2012 dollar value. Inflation is not computed into the projection figures.
Trends are assessed based on projected sales for existing products, new product introductions, expanded indications for existing products, and projected changes in the prevalence, diagnosis, and scripting rates for certain diseases.Included in this report are forecasts by product, product category and by company from 2009 through 2017. The study is arranged to offer an overview of the biologics market accompanied by product, company, geography and mechanism of action with forecasts broken down and covered by geographic region or country. Virtually the entire globe is covered to include prevalence data for each disease subsegment.Excluded from this report are over-the-counter (OTC) medications and other consumables that do not require a physician's prescription.Sales figures are reported in U.S. dollars and in each case reflect currency fluctuations within the performance of revenue change. Revenue figures do not account for variation in local currencies.All market share data presented are on a global basis unless specifically noted.
INTENDED AUDIENCE
- Established companies in the industry shall benefit from the contents, including corporate strategy, sales and marketing, business development, and research and development (R&D).
- Emerging biopharma and biotechnology players in the segment must understand specific opportunities for out-licensing, originating from the elements of differentiation of their therapeutic drug as compared to leading, competitive and emerging therapies. As well, market forecasts can support investment, provided a thorough and detailed substantiation is provided for the market forecast, as is found in this study.
- Investment firms evaluating candidates for venture capital or hedged investments will gain insights as to the opportunity and risks that are being encountered in the industry in a product and company specific analysis.
- Equity analysts are provided detailed forecasts for the next five years, substantiated by quantitative analysis that can support further analysis to product and company forecasts over the short and long run.
METHODOLOGY AND INFORMATION SOURCES
ANALYST'S CREDENTIALS Jackson Highsmith REPORT HIGHLIGHTS- An overview of the global market for biologic therapeutic drugs
- Analyses of global market trends, with data from 2011, estimates for 2012, and projections of compound annual growth rates (CAGRs) through 2017
- Coverage of large market segments such as monoclonal antibodies (mAb), therapeutic proteins, and vaccines
- Examination of the competitive environment with a special focus on how new products and technologies are influencing the current standard of care
- Comprehensive profiles of current market leaders, as well as companies with innovative products poised to advance within the forecast period.
TABLE OF CONTENTS
STUDY GOALS AND OBJECTIVES 1
REASONS FOR DOING THE STUDY 1
SCOPE OF REPORT 1
INTENDED AUDIENCE 2
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST'S CREDENTIALS 3
RELATED REPORTS 3
BCC ON-LINE SERVICES 3
DISCLAIMER 4
CHAPTER 2 EXECUTIVE SUMMARY 6SUMMARY TABLE GLOBAL BIOLOGICS MARKET FORECAST BY TYPE OF PRODUCT,THROUGH 2017 ($ MILLIONS) 6SUMMARY FIGURE GLOBAL BIOLOGICS MARKET FORECAST BY TYPE OF PRODUCT,2009-2017 ($ MILLIONS) 6
CHAPTER 3 OVERVIEW 9
BIOLOGICS NEW PRODUCTS IN DISEASE TREATMENT 9
TABLE 1 SUBCLASSES OF BIOLOGICS DRUGS 10
MONOCLONAL ANTIBODIES 10
FIGURE 1 DIAGRAM OF TYPICAL ANTIBODY STRUCTURE 11
THERAPEUTIC PROTEINS 12
HEMOPOIETIC GROWTH FACTORS (HGFS) 12
Cytokines 13
Blood Factors 13
VACCINES 14
Traditional Vaccines 14
Novel Vaccine Technologies 14
MAJOR BIOLOGICS PRODUCT CLASSES 15
TABLE 2 MONOCLONAL ANTIBODY AND THERAPEUTIC PROTEIN DRUGS SUBCLASSES 15
TABLE 3 GLOBAL BIOLOGICS MARKET REVENUE, THROUGH 2017 ($ MILLIONS) 15
CHALLENGES WITH RNAI 16
ORPHAN DRUG DESIGNATION 17
CHAPTER 4 BIOPHARMACEUTICAL INDUSTRY AND COMPETITIVE ANALYSIS 20BIOPHARMACEUTICAL INDUSTRY STRUCTURE 20THE ORIGINS OF BIOTECHNOLOGY 20INVOLVEMENT OF LARGE PHARMACEUTICAL COMPANIES 21
CHAPTER 5 BIOLOGICS MARKET OVERVIEW 23
TABLE 4 MAJOR BIOPHARMACEUTICAL PLAYERS BY REVENUE, 2011 ($ MILLIONS) 23
TABLE 5 TOP 25 BIOPHARMACEUTICAL PRODUCTS BY REVENUE, 2011 ($ MILLIONS) 24
TABLE 6 TOP 50 REVENUE GENERATING BIOPHARMACEUTICAL PRODUCTS, 2010 ($
MILLIONS) 25
MONOCLONAL ANTIBODIES 26
TABLE 7 GLOBAL MARKET FORECAST FOR MABS, THROUGH 2017 ($ MILLIONS) 27
TABLE 8 LEADING MONOCLONAL ANTIBODY PRODUCTS, 2011 ($ MILLIONS) 27
TABLE 9 VOLUME OF MAMMALIAN CELL CULTURE PRODUCED MABS, 2012 AND 2017 28
CONJUGATED ANTIBODIES 29
ANTIBODY FRAGMENTS 30
LARGE PHARMACEUTICAL COMPANIES AND BIOPHARMA 30
LARGE PHARMACEUTICAL COMPANY CONSORTIUM FORMED 31
THERAPEUTIC PROTEINS 31
TABLE 10 REVENUE FOR THERAPEUTIC PROTEINS SEGMENT OF BIOLOGICS MARKET,
THROUGH 2017 ($ MILLIONS) 32
HEMOPOIETIC GROWTH FACTORS 32
TABLE 11 LEADING HEMOPOIETIC GROWTH FACTOR BIOLOGIC PRODUCTS ($ MILLIONS) 33
Hemopoietic Growth Factor Clinical Trials 34
TABLE 12 CLINICAL TRIALS ON G-CSF RECEPTORS IN 2012 34
CYTOKINES 35
TABLE 13 CLINICAL TRIALS ON CYTOKINES UNDERWAY IN 2012 36
ANTIHEMOPHILIA PRODUCTS 37
TABLE 14 TOP 30 REVENUE-GENERATING THERAPEUTIC PROTEIN PRODUCTS, 2011 ($
MILLIONS) 37
VACCINES 39
VACCINE MARKET REVENUES 39
TABLE 15 VACCINE REVENUES, THROUGH 2017 ($ MILLIONS) 40
TABLE 16 CLINICAL TRIALS ON VACCINES, 2012 40
CHAPTER 6 IMPACT OF BIOSIMILAR DRUGS ON BIOLOGICS MARKET 43TABLE 17 PATENT AND MARKETING EXCLUSIVITY EXPIRATION FOR TOP SELLINGBIOLOGICS 44TABLE 18 NUMBER OF BIOSIMILARS PREDICTED TO BE LAUNCHED DURING PERIOD2012-2019 44TABLE 19 TOP 10 BIOLOGICS DRUGS IN (2011 REVENUES) WITH GREATEST LEVEL OFBIOSIMILAR COMPETITION ($ MILLIONS) 45RATIONALE FOR BIOSIMILAR DEVELOPMENT 45ERYTHROPOIETIN 45GRANULOCYTE-COLONY STIMULATING FACTOR 46INTERFERONS 46HUMAN GROWTH HORMONE 46OPPORTUNITY AND THREAT FROM BIOSIMILARS 46MARKET TRENDS: GROWTH DRIVERS AND RESISTORS 47BIOSIMILARS: REGULATORY UPDATE 48U.S. FDA 48EUROPEAN BIOSIMILAR REGULATORY GUIDANCE 48
CHAPTER 7 MAJOR PLAYERS IN BIOLOGIC AND BIOSIMILARS DRUG MARKET 51
MONOCLONAL ANTIBODIES 51
TABLE 20 TOP 10 SELLING MABS IN 2011 51
TABLE 21 MAJOR PLAYERS (BY REVENUE) IN MAB MARKET IN 2011 ($ MILLIONS) 52
THERAPEUTIC PROTEINS 52
TABLE 22 TOP 10 THERAPEUTIC PROTEIN PRODUCTS, 2011 ($ MILLIONS) 53
TABLE 23 MAJOR PLAYERS (BY REVENUE) IN THE THERAPEUTIC PROTEINS MARKET, 2011
($ MILLIONS) 53
VACCINES 54
TABLE 24 TOP 10 VACCINES BY REVENUE, 2011 ($ MILLIONS) 55
CHAPTER 8 GEOGRAPHIC DISTRIBUTION OF BIOLOGICS MARKET 57GEOGRAPHIC MARKET ANALYSIS 57TABLE 25 GEOGRAPHIC DISTRIBUTION OF TOTAL BIOLOGICS MARKET, THROUGH 2017 ($MILLIONS, % OF TOTAL) 58
CHAPTER 9 PIPELINE ANALYSIS 60
TABLE 26 BIOLOGIC DRUGS OBTAINING FDA APPROVAL FROM 2010 TO 2012 60
BIOLOGICS IN COMPANY PIPELINES 2012 61
AMGEN 61
TABLE 27 AMGEN BIOLOGICS PIPELINE, 2012 61
ROCHE 62
TABLE 28 ROCHE/GENENTECH/CHUGAI BIOLOGICS PIPELINE, 2012 62
BAYER 63
TABLE 29 BAYER BIOLOGICS PIPELINE, 2012 63
NOVO NORDISK 64
TABLE 30 NOVO NORDISK BIOLOGICS PIPELINE, 2012 64
MERCK 65
TABLE 31 MERCK BIOLOGICS PIPELINE, 2012 65
PFIZER 65
TABLE 32 PFIZER BIOLOGICS PIPELINE, 2012 66
BIOGEN IDEC 66
TABLE 33 BIOGEN IDEC BIOLOGICS PIPELINE, 2012 67
SANOFI 67
TABLE 34 SANOFI BIOLOGICS PIPELINE, 2012 68
CHAPTER 10 BIOLOGICS CLINICAL TRIALS 70TABLE 35 DESCRIPTION OF PHASES OF CLINICAL TRIALS REQUIRED FOR NEW DRUGAPPROVAL 70CANCER BIOLOGIC DRUGS 71TABLE 36 LIST (PARTIAL) OF BIOLOGIC DRUGS IN CLINICAL TRIAL FOR CANCERTREATMENT, 2012 71GASTROINTESTINAL AND RELATED DISEASES 74TABLE 37 LIST (PARTIAL) OF BIOLOGIC DRUGS IN CLINICAL TRIAL FOR GI AND RELATEDDISEASE TREATMENT, 2012 74HEART DISEASE 75TABLE 38 LIST (PARTIAL) OF BIOLOGIC DRUGS IN CLINICAL TRIAL FOR HEART ANDRELATED DISEASE TREATMENT, 2012 76
CHAPTER 11 MERGER AND ACQUISITIONS IN BIOLOGICS AREA 78
TABLE 39 LICENSING, DEVELOPMENT AGREEMENTS, ACQUISITIONS AND PARTNERSHIPS
IN BIOLOGICS 78
TABLE 40 LICENSING, DEVELOPMENT AGREEMENTS, ACQUISITIONS AND PARTNERSHIPS
IN BIOLOGICS (CONTINUED) 82
CHAPTER 12 PATENTS FOR BIOLOGIC DRUGS 90MONOCLONAL ANTIBODY PATENTS 90TABLE 41 U.S. PATENTS FOR MONOCLONAL ANTIBODIES 90THERAPEUTIC PROTEIN PATENTS 93TABLE 42 PATENTS ISSUED FOR THERAPEUTIC PROTEINS 93VACCINE PATENTS 96TABLE 43 PATENTS ISSUED FOR VACCINES (OR VACCINE RELATED PRODUCTS)ASSOCIATED WITH BIOLOGICALS 96
CHAPTER 13 BIOLOGICS MANUFACTURING 100
BIOPHARMACEUTICAL MANUFACTURING PROCESS 100
THE PREPARATION PROCESS 101
Cell Banking and Seed Culture 101
Production 101
Cell Culture Formats 101
Batch and Continuous Processing 102
Perfusion and Fed-Batch Mode 102
TABLE 44 BIOLOGICS PRODUCTS USING PERFUSION METHOD 103
Perfusion Methods 103
Fed-Batch Methods 103
TABLE 45 BIOLOGICS THERAPEUTIC PRODUCTS USING FED-BATCH METHOD 104
Harvest and Concentration 104
THE FINISHING PROCESS 104
PURIFICATION OF BIOPHARMACEUTICALS 105
AUTOMATED PROCESSING SYSTEMS-SKIDS 106
FORMULATION 107
LYOPHILIZATION 107
CRYOGRANULATION 107
SPRAY DRYING 107
UNDERCOOLING 108
PROCESS INTEGRATION: THE CRITICAL ACTIVITY 108
EXPRESSION SYSTEMS FOR THERAPEUTIC PROTEIN PRODUCTION 108
MICROBIAL THERAPEUTIC PROTEIN PRODUCTION 109
E.COLI ADVANTAGES FOR MICROBIAL PRODUCTION 109
Fast Accumulation 109
Safety Advantage 109
Growth on Inexpensive Carbon Sources 109
Propensity for High-Cell-Density Fermentations 109
Simple Process Scale-Up 110
TABLE 46 MARKETED BIOPHARMACEUTICALS USING E.COLI EXPRESSION SYSTEM 110
MAMMALIAN CELL THERAPEUTIC PROTEIN PRODUCTION 110
TABLE 47 MARKETED BIOPHARMACEUTICALS USING ANIMAL CELL LINE EXPRESSION
SYSTEM 111
EMERGING PRODUCTION SYSTEMS 112
PICHIA AND FILAMENTOUS FUNGI 112
TRANSGENIC PROTEIN PRODUCTION SYSTEMS 113
TRANSGENIC PLANTS 113
TABLE 48 PLANT-BASED TRANSGENIC COMPANIES AND THEIR PIPELINES OF
RECOMBINANT PROTEINS 114
TRANSGENIC ANIMALS 115
TABLE 49 THERAPEUTIC PROTEINS PRODUCED IN TRANSGENIC ANIMALS 115
TABLE 50 MARKETED BIOPHARMACEUTICALS USING MURINE (MOUSE) HYBRIDOMA
EXPRESSION SYSTEM 117
CHAPTER 14 COMPANY PROFILES 119ABBOTT LABORATORIES 119BIOLOGICAL PRODUCTS 119ADVAXIS INC. 119BIOLOGICAL PRODUCTS 120AGENNIX AG 120AKEBIA THERAPEUTICS INC. 121AMGEN INC. 121BIOLOGICAL PRODUCTS 121APOGENIX GMBH 122BAXTER BIOSCIENCE INC. 122BIOLOGICAL PRODUCTS 123BAYER SCHERING PHARMA AG 123BIOLOGICAL PRODUCTS 123BIOGEN IDEC INC. 124BIOLOGICAL PRODUCTS 124BIOINVENT INTERNATIONAL AB 124BIOLOGICAL PRODUCTS 125BIOVITRUM AB 125CELLDEX THERAPEUTICS INC. 125BIOLOGICAL PRODUCTS 126CHUGAI PHARMACEUTICALS 126BIOLOGICAL PRODUCTS 126CSL BEHRING 126BIOLOGICAL PRODUCTS 127CYTHERIS SA 127DEBIOPHARM GROUP 127DENDREON CORPORATION 128DYAX CORP. 128BIOLOGICAL PRODUCTS 129ELI LILLY & CO. 129BIOLOGICAL PRODUCTS 129ERYTECH PHARMA 130BIOLOGICAL PRODUCTS 130GENENTECH INC. 130BIOLOGICAL PRODUCTS 131GENMAB A/S 131BIOLOGICAL PRODUCTS 131GENZYME CORPORATION 132BIOLOGICAL PRODUCTS 132GLAXOSMITHKLINE PLC 132BIOLOGICAL PRODUCTS 133GLYCOTOPE GMBH 133BIOLOGICAL PRODUCTS 134H. LUNDBECK A/S 134CURRENT PRODUCTS 134HAWAII BIOTECH INC. 135HELIX BIOPHARMA CORPORATION 135HUMAN GENOME SCIENCES INC. 135BIOLOGICAL PRODUCTS 136IMCLONE SYSTEMS INC. 136BIOLOGICAL PRODUCTS 137IMMUNOGEN INC. 137BIOLOGICAL PRODUCTS 137IMMUNOVACCINE TECHNOLOGIES INC. 138BIOLOGICAL PRODUCTS 138IMMUTEP S.A. 138BIOLOGICAL PRODUCTS 139INNATE PHARMA 139BIOLOGICAL PRODUCTS 139INTERCELL AG 140BIOLOGICAL PRODUCTS 140IPSEN 140BIOLOGICAL PRODUCTS 141MEDAREX INC. 141BIOLOGICAL PRODUCTS 141MERCK & CO. INC. USA 142BIOLOGICAL PRODUCTS 142MERCK SERONO S.A. 142BIOLOGICAL PRODUCTS 142NOVARTIS AG 143BIOLOGICAL PRODUCTS 143NOVO NORDISK A/S 143BIOLOGICAL PRODUCTS 144OCTAPHARMA AG 144BIOLOGICAL PRODUCTS 144PFIZER INC. 145BIOLOGICAL PRODUCTS 145PHOSPHAGENICS LIMITED 145PROTEON THERAPEUTICS INC. 146ROCHE LTD. 146BIOLOGICAL PRODUCTS 146SANOFI-AVENTIS 147BIOLOGICAL PRODUCTS 147SEATTLE GENETICS INC. 147BIOLOGICAL PRODUCTS 148SHIRE PLC 148BIOLOGICAL PRODUCTS 149SOLIGENIX INC. 149TEVA PHARMACEUTICAL INDUSTRIES LTD. 149BIOLOGICAL PRODUCTS 150THROMBOGENICS NV 150BIOLOGICAL PRODUCTS 151TOLERX INC. 151TRIPEP AB 151TRUBION PHARMACEUTICALS INC. 152UCB S. A. 152BIOLOGICAL PRODUCTS 153VICAL INC. 153BIOLOGICAL PRODUCTS 154WILEX AG 154XCELLEREX INC. 154ZYMOGENETICS INC. 155BIOLOGICAL PRODUCTS 155
LIST OF TABLES
2017 ($ MILLIONS) 6
TABLE 1 SUBCLASSES OF BIOLOGICS DRUGS 10
TABLE 2 MONOCLONAL ANTIBODY AND THERAPEUTIC PROTEIN DRUGS SUBCLASSES 15
TABLE 3 GLOBAL BIOLOGICS MARKET REVENUE, THROUGH 2017 ($ MILLIONS) 15
TABLE 4 MAJOR BIOPHARMACEUTICAL PLAYERS BY REVENUE, 2011 ($ MILLIONS) 23
TABLE 5 TOP 25 BIOPHARMACEUTICAL PRODUCTS BY REVENUE, 2011 ($ MILLIONS) 24
TABLE 6 TOP 50 REVENUE GENERATING BIOPHARMACEUTICAL PRODUCTS, 2010 ($
MILLIONS) 25
TABLE 7 GLOBAL MARKET FORECAST FOR MABS, THROUGH 2017 ($ MILLIONS) 27
TABLE 8 LEADING MONOCLONAL ANTIBODY PRODUCTS, 2011 ($ MILLIONS) 27
TABLE 9 VOLUME OF MAMMALIAN CELL CULTURE PRODUCED MABS, 2012 AND 2017 28
TABLE 10 REVENUE FOR THERAPEUTIC PROTEINS SEGMENT OF BIOLOGICS MARKET,
THROUGH 2017 ($ MILLIONS) 32
TABLE 11 LEADING HEMOPOIETIC GROWTH FACTOR BIOLOGIC PRODUCTS ($ MILLIONS) 33
TABLE 12 CLINICAL TRIALS ON G-CSF RECEPTORS IN 2012 34
TABLE 13 CLINICAL TRIALS ON CYTOKINES UNDERWAY IN 2012 36
TABLE 14 TOP 30 REVENUE-GENERATING THERAPEUTIC PROTEIN PRODUCTS, 2011 ($
MILLIONS) 37
TABLE 15 VACCINE REVENUES, THROUGH 2017 ($ MILLIONS) 40
TABLE 16 CLINICAL TRIALS ON VACCINES, 2012 40
TABLE 17 PATENT AND MARKETING EXCLUSIVITY EXPIRATION FOR TOP SELLING
BIOLOGICS 44
TABLE 18 NUMBER OF BIOSIMILARS PREDICTED TO BE LAUNCHED DURING PERIOD
2012-2019 44
TABLE 19 TOP 10 BIOLOGICS DRUGS IN (2011 REVENUES) WITH GREATEST LEVEL OF
BIOSIMILAR COMPETITION ($ MILLIONS) 45
TABLE 20 TOP 10 SELLING MABS IN 2011 51
TABLE 21 MAJOR PLAYERS (BY REVENUE) IN MAB MARKET IN 2011 ($ MILLIONS) 52
TABLE 22 TOP 10 THERAPEUTIC PROTEIN PRODUCTS, 2011 ($ MILLIONS) 53
TABLE 23 MAJOR PLAYERS (BY REVENUE) IN THE THERAPEUTIC PROTEINS MARKET, 2011 ($
MILLIONS) 53
TABLE 24 TOP 10 VACCINES BY REVENUE, 2011 ($ MILLIONS) 55
TABLE 25 GEOGRAPHIC DISTRIBUTION OF TOTAL BIOLOGICS MARKET, THROUGH 2017 ($
MILLIONS, % OF TOTAL) 58
TABLE 26 BIOLOGIC DRUGS OBTAINING FDA APPROVAL FROM 2010 TO 2012 60
TABLE 27 AMGEN BIOLOGICS PIPELINE, 2012 61
TABLE 28 ROCHE/GENENTECH/CHUGAI BIOLOGICS PIPELINE, 2012 62
TABLE 29 BAYER BIOLOGICS PIPELINE, 2012 63
TABLE 30 NOVO NORDISK BIOLOGICS PIPELINE, 2012 64
TABLE 31 MERCK BIOLOGICS PIPELINE, 2012 65
TABLE 32 PFIZER BIOLOGICS PIPELINE, 2012 66
TABLE 33 BIOGEN IDEC BIOLOGICS PIPELINE, 2012 67
TABLE 34 SANOFI BIOLOGICS PIPELINE, 2012 68
TABLE 35 DESCRIPTION OF PHASES OF CLINICAL TRIALS REQUIRED FOR NEW DRUG
APPROVAL 70
TABLE 36 LIST (PARTIAL) OF BIOLOGIC DRUGS IN CLINICAL TRIAL FOR CANCER
TREATMENT, 2012 71
TABLE 37 LIST (PARTIAL) OF BIOLOGIC DRUGS IN CLINICAL TRIAL FOR GI AND RELATED
DISEASE TREATMENT, 2012 74
TABLE 38 LIST (PARTIAL) OF BIOLOGIC DRUGS IN CLINICAL TRIAL FOR HEART AND
RELATED DISEASE TREATMENT, 2012 76
TABLE 39 LICENSING, DEVELOPMENT AGREEMENTS, ACQUISITIONS AND PARTNERSHIPS
IN BIOLOGICS 78
TABLE 40 LICENSING, DEVELOPMENT AGREEMENTS, ACQUISITIONS AND PARTNERSHIPS
IN BIOLOGICS (CONTINUED) 82
TABLE 41 U.S. PATENTS FOR MONOCLONAL ANTIBODIES 90
TABLE 42 PATENTS ISSUED FOR THERAPEUTIC PROTEINS 93
TABLE 43 PATENTS ISSUED FOR VACCINES (OR VACCINE RELATED PRODUCTS) ASSOCIATED
WITH BIOLOGICALS 96
TABLE 44 BIOLOGICS PRODUCTS USING PERFUSION METHOD 103
TABLE 45 BIOLOGICS THERAPEUTIC PRODUCTS USING FED-BATCH METHOD 104
TABLE 46 MARKETED BIOPHARMACEUTICALS USING E.COLI EXPRESSION SYSTEM 110
TABLE 47 MARKETED BIOPHARMACEUTICALS USING ANIMAL CELL LINE EXPRESSION
SYSTEM 111
TABLE 48 PLANT-BASED TRANSGENIC COMPANIES AND THEIR PIPELINES OF
RECOMBINANT PROTEINS 114
TABLE 49 THERAPEUTIC PROTEINS PRODUCED IN TRANSGENIC ANIMALS 115
TABLE 50 MARKETED BIOPHARMACEUTICALS USING MURINE (MOUSE) HYBRIDOMA
EXPRESSION SYSTEM 117
BIO079B - Biologic Therapeutic Drugs: Technologies and Global Markets
LIST OF FIGURES
2009-2017 ($ MILLIONS) 6
FIGURE 1 DIAGRAM OF TYPICAL ANTIBODY STRUCTURE 11
To order this report:Biopharmaceutical Industry: Biologic Therapeutic Drugs: Technologies and Global Markets
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