These data will be presented at the 2016 San Antonio Breast Cancer Symposium (SABCS) in San Antonio, Texas. BCI is developed and marketed by Biotheranostics, Inc., a pioneer in molecular diagnostics for cancer.
Investigators conducted analyses of nearly 500 patients from two cohorts where risk of distant recurrence was assessed in patients with small tumors (T1) and node negative disease—traditionally considered features that are associated with a low risk of disease relapse. In one cohort, BCI identified 22% of T1N0 patients as High Risk for relapse within the first 5 years, and these patients had a significantly reduced distant recurrence-free survival (DRFS, 77.3%) compared to BCI Low Risk patients (96.2%; P=0.0001). In patients who were disease-free at year 5, BCI identified 36% of patients as high risk for late recurrence; these patients had significantly lower DRFS (89.6%) between years 5-10 compared to BCI low risk patients (98.4%; P=0.008).
"These analyses further support our knowledge that BCI can help many patients with ER+, early-stage breast cancer better mitigate their long-term risk of tumor recurrence with proactive and appropriate use of extended anti-estrogen therapy," added Dr. Schnabel. "As we continue to analyze the results of these studies, we become more and more confident that adding Breast Cancer Index to traditional clinical and pathological factors to assess risk, could be the difference between lasting remission and tumor recurrence for as many as one in every three early stage patients with ER+ tumors."
About Breast Cancer IndexSM
BCI is a molecular, gene expression-based test uniquely positioned to help identify patients best suited for extended endocrine treatment. It is the only validated, commercially available test with data demonstrating prognostic risk of recurrence out to 15 years, as well as prediction of likelihood of benefit from extended endocrine therapy (treatment in years 5-10). The breakthrough test helps oncologists and patients navigate the difficult trade-off between wanting to take steps to prevent recurrence of their disease and facing significant side effects and safety challenges related to extended endocrine therapy. For more information, visit www.breastcancerindex.com.
Biotheranostics, Inc., is a leader in helping physicians improve the care of cancer patients, offering a suite of proprietary genomics-based molecular diagnostics that allow treatment to be tailored to individual patients. The company's Breast Cancer Index and CancerTYPE ID® tests address a variety of unmet medical needs in the management of cancer patients, and extensive clinical studies have confirmed the accuracy, clinical validity, clinical utility, and cost-effectiveness of the tests. Biotheranostics operates a CLIA-certified, CAP-accredited diagnostic laboratory in San Diego. Learn more at biotheranostics.com.
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/breast-cancer-indexsm-predicted-patients-at-high-risk-of-recurrence-despite-low-risk-clinical-features-new-data-suggest-300375352.html