Breast cancer patients benefit from new pain control regimen that shortens hospital stay after reconstruction

Opioid addiction has grown to epidemic proportions in the United States and most commonly starts with misuse of prescription drugs. Two million Americans suffer from opioid use disorder involving prescription medications while more than 20,000 deaths annually are attributed to opioids. The National Institute of Health has announced "an all hands on deck" approach to dealing with the crisis.  

Considering these facts, and knowing that opioids' side effects such as nausea and lethargy frequently delay patient's recovery and increase their hospital length of stay, Mark L. Smith, MD, vice-chair of the Department of Surgery at Northwell Health and director of reconstructive oncology at Northwell Health Cancer Institute, was driven to find an alternative to the mainstay of postoperative pain control – intravenous and oral opioids.

"By substituting non-steroidal, anti-inflammatory medication for opioids and using long-acting nerve blocks that work locally to minimize pain at the surgical site, our patients not only had less pain, but avoided the effects of opioids like grogginess and nausea. This allowed them to get up and walk sooner and leave the hospital on their second day instead of the national average of four to five days," said Dr. Smith. "Our patients are pleased to be back to their lives more quickly and relieved not to deal with opioid side effects or risk of dependence."

Dr. Smith and his team found they could effectively block post-operative pain by using a combination of anesthetic injections, including a technique called "transversus abdominis plane block," or "TAP block." The drug they used for the injections, liposomal bupivacaine, can provide local pain relief for two to three days, when pain is typically greatest. Although a number of papers have shown the efficacy of liposomal bupivacaine in providing long-term analgesia for various nerve blocks, it is still only approved by US Food and Drug Administration for direct injection into wounds.

Breast reconstruction with abdominally-based flap surgery is an alternative to using implants – it involves microsurgically transplanting fatty tissue from the lower abdomen to the breast region to create a new breast mound. Many women prefer to use their own tissue for reconstruction to avoid implants and their potential long-term complications, but are concerned about the recovery after abdominal surgery.

"After facing breast cancer and a double mastectomy, I didn't want to also confront the side effects of opioids or the potential of being dependent on opioids," said Lynn Bertsch, of Plainview, NY, and patient of Dr. Smith. "I thought it was important to my recovery to not be in a fog – I wanted to drive – and I wanted my body to feel healthy and clean. My recovery exceeded my expectations. My pain was completely manageable and by the time I was itching to get home, I was there sitting up in my favorite chair and even walking around."

Hospitals that are trying the new pain regimen and seeing benefits for their patients include Long Island Jewish Medical Center in New Hyde Park, Southside Hospital in Bay Shore, Huntington Hospital, North Shore University Hospital in Manhasset and Staten Island University Hospital. Dr. Smith, who presented his findings at the annual meetings of American Society of Plastic Surgeons and the World Society of Reconstructive Microsurgery, hopes that his findings will encourage other doctors to examine the use of long-term blocks to improve outcomes and that his research will help hasten FDA approval of liposomal bupivacaine for nerve blocks.

About the Feinstein Institute
The Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the Feinstein includes 4,000 researchers and staff who are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine – a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit FeinsteinInstitute.org.

Contact: Heather E. Ball
516-465-7917
[email protected]

SOURCE Northwell Health

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