With time being a critical factor in cardiac arrest, Feinstein Institute Investigator Junhwan Kim and his team were looking for a more immediate indicator of the period the body is deprived of oxygen to better determine if the patient will survive and return to normal function.
"Having a method to detect the onset of cardiac arrest and the length of oxygen deprivation will help physicians make more informed decisions regarding treatment," said Junhwan Kim, investigator at the Feinstein Institute and lead author of the Biomarker paper. "Patients and their families will benefit as doctors will be able to more immediately assess the severity of the patient's injuries and have more definitive indicators of survival."
For this study, researchers monitored the change in a lipid metabolite, or molecule, called lysophosphatidylinositol, which increases when there's a lack of oxygen. Using an animal model, researchers looked at the levels of this molecule in the brain, kidney, liver, heart and blood before and five, 10, 20, 30 and 60 minutes after cardiac arrest. They found that the level of lysophosphatidylinositol increased in these major organs for up to 60 minutes post cardiac arrest. Having proved that lysophosphatidylinositol can indicate how long the body has been deprived of oxygen, Kim and his team are preparing to move into a human study where a blood sample is taken and tested immediately following cardiac arrest and post resuscitation. The results will have a significant impact on treatment and survival of patients with cardiac arrest.
"Junhwan Kim and his team are close to determining ways to better administer treatment following cardiac arrest," said Kevin J. Tracey, MD, president and CEO of the Feinstein Institute. "This has the potential to improve the lives of the nearly 300,000 Americans who suffer a cardiac arrest each year."
Click here to view the full paper.
About the Feinstein Institute
The Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the 2,000 researchers and staff of the Feinstein are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine – a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit FeinsteinInstitute.org.
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/feinstein-institute-scientists-identify-biomarker-to-predict-how-long-body-is-deprived-of-oxygen-during-cardiac-arrest-300379867.html
SOURCE The Feinstein Institute for Medical Research