Options for treating bacterial infections, especially those caused by Gram-negative bacteria, are becoming increasingly limited due to the exponential increase in antibiotic resistance. Urinary tract infections are the third leading indication for antibiotic therapy and where multidrug-resistant bacteria are becoming increasingly common.
Mannosides represent a new way of treating bacterial infections, by simply preventing the bacteria from being able to stick to the walls of the bladder thus allowing the body to naturally eliminate the infection.
"We are excited for this strategic relationship and partnership with GSK enabling the development of our first drug candidate. This and other types of antibiotic-sparing therapeutics will be essential to prevent and treat increasingly prevalent infectious disease syndromes caused by antibiotic-resistant pathogens," said Dr. Hultgren, President of Fimbrion Therapeutics.
"We are truly delighted to enter this collaboration to combine the disease expertise and mannoside discovery in Fimbrion with the drug discovery and development expertise of GSK for the development of a first-in-class therapeutic for the treatment of urinary tract infections," said Carolyn Buser-Doepner, Global Head of Discovery Partnerships with Academia. "Also exciting is that this is our group's first collaboration with a start-up biotechnology company."
Fimbrion's initial focus is the development and commercialization of an orally active drug to prevent and treat urinary tract infections (UTIs). Fimbrion will continue to further develop its platform technology and pipeline with additional narrow-spectrum antimicrobial strategies to combat UTIs and other bacterial infections that can overcome existing mechanisms of resistance and minimize the emergence of new ones. These novel narrow-spectrum antimicrobial strategies being developed by Fimbrion could be effective novel therapies for multiple bacterial infections, while being minimally disruptive to the non-pathogenic, resident beneficial microbiota.
About Fimbrion Therapeutics, Inc. Fimbrion Therapeutics, Inc. is a life sciences company based in St. Louis, MO founded in 2012 from intellectual property licensed from Washington University. Founders are Scott Hultgren, Ph.D., James Janetka, Ph.D., and Thomas Hooton, M.D. Fimbrion's mission is to discover, develop, and commercialize antimicrobial-sparing, first-in-class antivirulence drugs for the prevention and treatment of infectious diseases caused by bacteria, including drug-resistant strains. (www.fimbrion.com)
Scott J. Hultgren, Ph.D.
Fimbrion Therapeutics, Inc.
4320 Forest Park Ave., Suite 304
St. Louis, MO 63108
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SOURCE Fimbrion Therapeutics, Inc.