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First-Of-Its-Kind Clinical Trial At VA Pittsburgh Healthcare System

A bioengineered human acellular vessel may help veterans with kidney failure


News provided by

Veterans Research Foundation of Pittsburgh (VRFP)

May 29, 2019, 08:00 ET

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PITTSBURGH, May 29, 2019 /PRNewswire/ -- The VA Pittsburgh Healthcare System (VAPHS) in collaboration with the Veterans Research Foundation of Pittsburgh (VRFP) is participating in the first-of-its-kind clinical trial that will help doctors learn whether a new graft called human acellular vessel (HAV) works better than traditional approaches such as arteriovenous fistula (AVS) for hemodialysis (kidney dialysis) access.

The trial, sponsored by Humacyte, an innovator in biotechnology and regenerative medicine, includes about 240 adults with end-stage renal disease (ESRD) at roughly 30 sites across the United States. VA Pittsburgh Healthcare System is the only site in Pennsylvania and one of only three Department of Veterans Affairs sites conducting the trial. The data-collection process of the study will take two years.

Edith Tzeng, MD, Chief of Vascular Surgery, VA Pittsburgh Healthcare System is leading the trial.

For veterans with ESRD, a fistula is often the first choice for kidney dialysis access and is made by joining an artery to a vein to make a bigger blood vessel. HAV is a graft that has been made in a laboratory from cells and is surgically placed into the patient's arm, so it becomes more like a natural blood vessel and provides dialysis access.

The potential benefits of HAV being studied include better outcomes, a lower risk of infection, and earlier access for hemodialysis treatment.

To arrange an interview with Dr. Tzeng email [email protected]. For additional information about Humacyte and the bioengineered human acellular vessel (HAV), visit www.humacyte.com.

ABOUT VRFP & VAPHS
Authorized by Congress in the 1980s, VA affiliated Non-Profit Corporations (NPC's) exist to provide VA medical facilities with flexible funding mechanisms for the conduct of, and to facilitate functions, related to the conduct of approved research related activities or education and training at VA medical facilities. These NPC's are not owned or controlled by the Federal Government, nor are they an agency or instrumentality of the Federal Government.  Established in 1991, VRFP facilitates and supports extramural research and educational activities by collaborating with the VAPHS, private companies, government agencies, foundations, and academic institutions.

ABOUT HUMACYTE
Humacyte, Inc., a privately held company founded by Dr. Laura E. Niklason, M.D., Ph.D., in 2004 is a medical research, discovery and development company with clinical and pre-clinical stage investigation products.

SOURCE Veterans Research Foundation of Pittsburgh (VRFP)

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