2014

For Multiple Sclerosis Treatment, Prescriber Base for Genzyme's Aubagio Among U.S. Neurologists Has Increased Significantly at Six Months Post-launch, Compared to One and Three Months Post-launch However, Aubagio's Prescriber Base Continues to Lag Behind That of Novartis's Gilenya at Same Stage of Product Launch, According to a New Report from BioTrends Research Group

EXTON, Pa., May 30, 2013 /PRNewswire/ -- BioTrends Research Group, one of the world's leading research and advisory firms for specialized biopharmaceutical issues, finds that over half of surveyed neurologists have prescribed Aubagio, the second oral disease-modifying agent (DMA) marketed for multiple sclerosis (MS), to at least one of their MS patients at six months post-launch. While this represents a significant increase in prescriber base from one and three months post-launch, it does trail that observed with Gilenya (according to LaunchTrends: Gilenya Wave 3) at the same stage of product launch. This difference in prescriber base between the two oral DMAs is reflected in a smaller Aubagio patient share among DMA-treated relapsing-remitting MS (RR-MS) patients compared with the six-month share reported for Gilenya. Nevertheless, initial uptake of Aubagio continues to be driven by the product's convenient once-daily, oral formulation, with the majority of patients initiated on Aubagio still coming from switches.

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With Biogen Idec's Tecfidera being approved days before current survey fielding, substantial press coverage was given to the comparative wholesale prices across the DMAs, with Aubagio being the least expensive. Data from the LaunchTrends: Aubagio Wave 3 report suggest that this information has not had the expected impact on neurologists' perceptions of Aubagio's cost as significantly more of the 73 surveyed neurologists now perceive Aubagio as being more expensive than the other DMAs compared with previous waves. Furthermore, while current prescribers continue to express high overall satisfaction with Aubagio, especially for its efficacy, they rate their satisfaction with the product's cost significantly lower than at three months post-launch. Qualitative feedback suggests that difficulties with managed care coverage of Aubagio may be having a trickle-down effect on neurologists' perception of Aubagio's price.

"Given that neurologists report currently treating 9 percent of their DMA-treated RR-MS patients with the oral DMAs available at the time of survey fielding (Aubagio and Gilenya), it is interesting to note that surveyed neurologists expect the oral DMA group to capture 23 percent patient share over the next six months," said BioTrends Research Group Analyst Emma Williams, Ph.D. "Although this growth is anticipated to be driven predominantly by Tecfidera uptake, Aubagio patient share is also projected to significantly increase, while Gilenya patient share is expected to remain stable."

Overall, these results highlight neurologists' growing receptivity to oral DMAs and indicate a general shift in the MS treatment algorithm, away from the platform DMAs (Biogen Idec's Avonex, Bayer HealthCare's Betaseron, Teva's Copaxone and Pfizer/EMD Serono's Rebif) and Biogen Idec's Tysabri.

About BioTrends Research Group
BioTrends Research Group provides syndicated and custom primary market research to pharmaceutical manufacturers competing in clinically evolving, specialty pharmaceutical markets. For information on BioTrends publications and research capabilities, please visit www.bio-trends.com. BioTrends is a Decision Resources Group company.

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks of their respective holders.

For more information, contact:

Decision Resources Group
Christopher Comfort
781-993-2597
ccomfort@dresources.com

SOURCE BioTrends Research Group



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