Global Bone Grafts Industry

LONDON, June 18, 2014 /PRNewswire/ -- Reportbuyer.com has added a new market research report:

Global Bone Grafts Industry

http://www.reportbuyer.com/pharma_healthcare/healthcare/global_bone_grafts_industry.html

This report analyzes the worldwide markets for Bone Grafts in US$ Million. The US market for Bone Graft Substitutes is also analyzed by the following segments: Standard Allografts, Machined Bone Allografts, Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Bone Grafts, and Synthetic Bone Grafts. The report provides separate comprehensive analytics for the US, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2012 through 2020. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 61 companies including many key and niche players such as -

AlloSource
Biomet, Inc.
DePuy Synthes Companies
Exactech, Inc.
LifeNet Health, Inc.
Medtronic, Inc.

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
A. Standard Allografts I-3
B. Machined Bone Allografts I-3
C. Demineralized Bone Matrix (DBM) I-4
D. Bone Morphogenetic Protein (BMP) I-4
E. Stem Cell Based Bone Grafts I-4
F. Synthetic Bone Grafts I-4

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
Bone Grafts: A Prelude II-1
Bone Graft Substitute Market - Showcasing Promising Growth II-2
Growing Clinical Use of Bone Graft Substitutes in Surgical
Procedures II-2
Synthetic Bone Graft - The Latest Trend II-3
DBM: Strong Growth but Tough Competition II-3
Bone Morphogenetic Protein - Safety Concerns Affect Growth
Prospects II-4
Stem Cell Based Bone Grafts - Fastest Growing Bone Graft
Substitute Segment II-4
Developing Markets Hold Lucrative Potential for Bone Graft
Substitutes II-5
Autograft: Gold Standard for Bone Grafting Procedures II-5
Allografts: Leading the Race over Autografts II-6
Advanced Allografts Encroaching into the Use of Autografts in
Surgical Procedures II-6
Review of Major Factors Affecting Growth II-6
Aging Population: A Strong Demographic Driver II-6
Table 1: Percentage of 65+ Population in Total Population
for Select Countries (2012) (includes corresponding
Graph/Chart) II-7
Rising Incidences of Degenerative Intervertebral Disc Diseases II-8
Table 2: % of Women Affected by Osteoporosis (includes
corresponding Graph/Chart) II-8
Rising Prevalence of Arthritis and Other Orthopedic Disorders II-9
Rise in Revision Orthopedic Surgeries II-9
Rise in Spinal Fusions in Private Healthcare II-9
Applications of Bone Grafts II-9
Spine Fusion - The Largest Bone Graft Indication II-10
Dental Bone Grafting - A High Potential Market II-10
Table 3: Global Dental Regeneration Market (2013E):
Percentage Share Breakdown of Value Sales for Bone
Allografts, Membranes, Tissue Regeneration (includes
corresponding Graph/Chart) II-11
What Drives Physicians' Choice of Bone Grafts? II-11
Challenges for Different Bone Grafts II-11
Patient Safety Emerges as a Top Priority II-12
Competitive Scenario II-12

2. MARKET DYNAMICS II-14
Orthopedic Industry: An Overview II-14
Table 4: Fractures by Age Group (2012): Percentage Share
Breakdown of Number of Fractures by Age Group (includes
corresponding Graph/Chart) II-14

Table 5: Global Orthopedic Market by Segment (2013E):
Percentage Breakdown of Value Sales for Spine, Trauma, Knees,
Hips, Orthobiologics, Extremities and Others (includes
corresponding Graph/Chart) II-15
Is Consolidation Blowing in the Wind? II-15
Product Mix of Reconstructive Devices Companies II-16
Key Statistics in Global Orthopedics Industry II-16
Table 6: Worldwide Orthopedic Market (2013E): Percentage
Share Breakdown of Value Sales by Company for DePuy Synthes,
Stryker, Zimmer, Smith & Nephew, Medtronic, and Others
(includes corresponding Graph/Chart) II-16

Table 7: Worldwide Market for Orthopedic Implants in Spinal
Procedures (2013E): Percentage Share Breakdown of Value
Sales by Company for Medtronic, J&J and Others (includes
corresponding Graph/Chart) II-16

Table 8: Worldwide Market for Orthopedic Implants for
Reconstructive Procedures (2013E): Percentage Share
Breakdown of Value Sales by Company for Zimmer, J&J,
Stryker, Biomet, Smith & Nephew, and Others (includes
corresponding Graph/Chart) II-17

Table 9: Worldwide Market for Orthopedic Implants for Trauma
Procedures (2013E): Percentage Share Breakdown of Value
Sales by Company for J&J, Stryker, Biomet Smith & Nephew,
Zimmer, and Others (includes corresponding Graph/Chart) II-17

Table 10: Global Joint Replacement Market (2013E):
Percentage Share Breakdown of Sales for Zimmer, DePuy
Synthes, Stryker, Biomet, Smith & Nephew, and Others
(includes corresponding Graph/Chart) II-17
Orthobiologics Gain Traction in the Bone Grafts Market II-18
Table 11: Global Orthobiologics Market (2012): Percentage
Share Breakdown of Value Sales for Viscosupplements,
Allograft & DBM, Hemostasis, Synthetic Bone Graft
Substitutes, Growth Factors, and Blood & Marrow-based
Products (includes corresponding Graph/Chart) II-19

Table 12: Leading Players in the Global Orthobiologics Market
(2013): Percentage Share Breakdown of Value Sales for
Medtronic, J&J/Synthes, Sanofi, Baxter, Stryker, and Others
(includes corresponding Graph/Chart) II-19
Increasing Visibility of Orthobiological Products to Spur
Grafting Options II-20
Technological Advancements Drive the Market for Bone Grafts II-20
Synthetic Bone Grafts Set to Replace Conventional Autografts
and Allografts II-20
Foot and Extremity Reconstruction - Promising Market for Bone
Grafts II-21
Precision Machined Allograft Gain Surgeon Preference II-21
Unmet Clinical Needs to Foster R&D Engine II-21
Biological Solutions in Sports Medicine - Beyond Bone Grafting II-22
Disease Transmission through Bone Grafts - A Major Safety Concern II-22
Lack of Standards in Bone Graft Substitute Market II-22
Reimbursement Issues Continue to Haunt Bone Grafts Market II-22
Table 13: Payer Mix in Orthopedic-driven Surgeries Worldwide
(2012) (includes corresponding Graph/Chart) II-23
Regional Regulations & Religious Beliefs Hamper Bone Graft
Substitutes Market II-23
Synthetic Bone Grafts - Solution for Halal Bone Graft
Implantation II-23
Bone Glue - A Potential Threat to the Bone Graft Market II-24
Alliances with Organ Procurement Organizations: A Shot in the Arm II-24
Aging Baby Boomers Render a Decreased Donor Pool II-24
Limited Availability of Donor Tissues II-24
Intense Competition from Alternative Tissue Repair Therapies II-25
Substitute Technologies Threaten to Replace Spinal Fusions II-25
Bone Grafts Termed as Tissues Suffer From Inconsistent Patient
Outcomes II-25
Innovations in Orthopedic Biomaterials: A Glance at
Developments over the Years II-26
MPCs: Offer Promising Breakthroughs in Bone-Graft Substitute II-26
Peptide Signaling Molecules to the Rescue II-26
Prostaglandin Agonists: Emerging From their Drawbacks II-26
Synthetic Bone Grafts II-26
Combination of Bone Marrow and Bone Graft Substitute II-27
Stem Cell Therapy II-27
Bone Morphogenetic Proteins II-27
GEM OS®1 Shows Promise II-28
geneX® Synthetic Bone Graft Substitute II-28
ACCELL Total Bone Matrix II-28
New Ways of Fixing Broken Bones II-28
BoneCure Sleeve - Heading Towards the Human Market II-29
Bioactive Glass - Suitable for Weight Bearing Portion II-29
Tissue Recovery & Processing: A Review II-29
Tissue Banks II-29
Tissue Processing II-30
Tissue Distribution II-30
An Illustration of the Tissue Recovering, Processing, &
Distribution Network II-31

3. PRODUCT OVERVIEW II-32
Bone Grafts: A Definition II-32
Bone Grafts: A Peek into their Mechanism of Action II-32
Types of Bone Grafts II-33
Scoring of Osteoconduction, Osteoinduction, and Osteogenesis
Properties of Bone Grafts by Type II-33
Autografts II-33
Advantages II-33
Disadvantages II-34
Standard Allografts II-34
Advantages II-35
Disadvantages II-35
Machined Bone Allografts II-35
Commercially Available Allograft and Xenograft Bone Products II-36
Demineralized Bone Matrix II-36
Commercially Available Demineralized Bone Matrix Products II-36
Bone Morphogenetic Proteins (BMPs) II-37
Basic Functions of TGF-Beta II-37
Commercially Available BMP-Products in the Marketplace II-38
Infuse® II-38
OP-1 II-38
Synthetic Bone Grafts II-38
Collagen-based Matrices II-38
Advantages II-39
Disadvantages II-39
Ceramic: A Material of Choice II-39
Hydroxyapatite: A Major Calcium Phosphate Based Ceramic II-40
Calcium Sulfate II-40
Polymer Based Bone Grafts II-40
Coral: A Valuable Synthetic Graft Material II-40
Commercially Available Bone Substitutes Products II-41
Application of Bone Grafts II-43
Spinal Fusion II-43
Table 14: Worldwide Market for Orthopedic Implants in Spinal
Procedures (2010): Percentage Share Breakdown of Value Sales
by Application - Thoracolumbar, Interbody Devices, Vertebral
Compression Fractures, Cervical, and Electrical Stimulation
(includes corresponding Graph/Chart) II-43
Trauma & Reconstructive Surgeries II-44
Trauma II-44
Reconstructive Surgeries II-44
Joint Revision Arthroplasty II-44
Table 15: Worldwide Orthopedic Large Joint Market by
Segment (2013E): Percentage Share Breakdown of Value Sales
for Spine, Knee and Hip (includes corresponding
Graph/Chart) II-44

Table 16: Worldwide Orthopedic Extremities Market by
Segment (2013E): Percentage Share Breakdown of Value Sales
for Foot/Ankle, Shoulder, Wrist/Finger and Elbow (includes
corresponding Graph/Chart) II-44
Oral, Periodontal, and Cranio-Maxillofacial II-45
Table 17: Worldwide Market for Orthopedic Implants in
Trauma & Craniomaxillofacial Procedures (2010): Percentage
Share Breakdown of Value Sales by Application - Hip
Fracture, Lower Extremity, Neuro & Craniomaxillofacial,
Deformities, Pediatric & Foot and Upper Extremity
(includes corresponding Graph/Chart) II-45

4. REGULATORY ENVIRONMENT & REIMBURSEMENTS II-46
Regulatory Issues II-46
FDA Classification of Bone Products II-46
Human Cells, Tissues and Cellular and Tissue-Based Products (
HCT/Ps) II-46
National Organ Transplant Act (NOTA) II-47
Good Tissue Practices II-47
Tissue Banking Regulation II-47
FDA Regulations on Xenograft II-47
DBM-based Products in US II-48
Synthetic Bone Graft Substitutes II-48

5. PRODUCT INNOVATIONS/INTRODUCTIONS II-49
AlloSource Introduces AlloMend™ II-49
Orthofix Launches Trinity® ELITE™ II-49
Synergy Biomedical to Introduce Biosphere Putty II-49
K2M Launches VENADO Bone Graft Systems II-49
Bonesupport Receives CE Mark Approval for Cerament|G resorbable II-50
PlusLife® Launches Innovative Allogeneic Bone Gel™ for
Orthopedic Uses (Australia) II-50
RTI Surgical Introduces BioReady DBM Putty II-50
K2M Rolls Out VESUVIUS Osteobiologic Systems II-51
BioHorizons Introduces MinerOss® Cancellous II-51
Amedica Introduces Dynamic Bone II-51
Orthogen Introduces NanoGen II-51
SIRAKOSS Introduces MaxSi II-52
BioMimetic to Introduce Augmatrix™ Biocomposite Bone Graft Line II-52
Orthofix International Introduces Collage™ Osteoconductive
Scaffold II-52
BioMimetic Obtains Approval from TGA for Commercialization of
Augment® Bone Graft II-52
Medtronic Launches ARTISAN™ Space Maintenance System II-53
NovaBone Introduces MacroPor-Si+ II-53
RTI Surgical Announces First Application of map3TM Cellular
Allogeneic Bone Graft in Ankle and Foot Fusion Procedures (
US) II-53
Integra Receives FDA Clearance for Accell Evo3 II-53
RTI Surgical Introduces BioAdapt™ DBM Foam II-54
Integra Unveils Trel-Xpress™ Demineralized Bone Matrix II-54
Keystone Dental Introduces DynaMatrix™ Plus II-54
Wright Introduces FUSIONFLEX™ Demineralized Moldable Scaffold II-54
Micromedics Launches OsteoXpress 15cc Bone Graft Delivery Device II-54
Bacterin Unveils OsteoSponge®SC II-55
Integra Launches Allograft Cancellous Sponge II-55
Orthos Receives CE Approval for ßGel Synthetic Bone Graft
Substitute II-55

6. RECENT INDUSTRY ACTIVITY II-56
RTI Biologics Acquires Pioneer Surgical Technology II-56
Wright Medical Group Acquires BioMimetic Therapeutics II-56
Titan Spine Enters into Distribution Agreement with Biomet II-56
Bioventus and Pfizer Enter into Agreement II-57
AlloSource Enters into Partnership with Humacyte II-57
MicroPort Medical to Acquire OrthoRecon Business of Wright
Medical Group II-57
J&J Takes Over Synthes II-58
Stryker Acquires Orthovita II-58
Zimmer Dental and Curasan Enter into Distribution Agreement II-58
Cayenne Medical Enters into Partnership with Parametrics Medical II-59
NuVasive Signs Licensing Agreement with AlloSource II-59
Stryker Divests OP-1 Product Range II-59

7. FOCUS ON SELECT PLAYERS II-60
AlloSource (USA) II-60
Biomet, Inc. (USA) II-60
DePuy Synthes Companies (USA) II-61
Synthes Inc (USA) II-61
DePuy Spine, Inc. (USA) II-62
Exactech, Inc. (USA) II-62
Integra LifeSciences Holdings Corporation (USA) II-62
LifeNet Health, Inc. (USA) II-63
Medtronic, Inc. (USA) II-63
NovaBone Products LLC (USA) II-64
NuVasive, Inc. (USA) II-64
Olympus Biotech Corporation (USA) II-65
RTI Surgical, Inc. (USA) II-65
Smith & Nephew Plc (UK) II-65
Stryker Corporation (USA) II-66
Wright Medical Technology, Inc. (USA) II-67
BioMimetic Therapeutics LLC (USA) II-67
Zimmer Holdings, Inc. (USA) II-68

8. MARKET PERSPECTIVE II-69
Table 18: World Recent Past, Current and Future Analysis for
Bone Graft Substitutes by Geographic Region/Country - US,
Europe and Rest of World Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2012 through
2020 (includes corresponding Graph/Chart) II-69

Table 19: World Historic Review for Bone Graft Substitutes by
Geographic Region/Country - US, Europe and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2006 through 2011 (includes
corresponding Graph/Chart) II-70

Table 20: World 15-Year Perspective for Bone Graft Substitutes
by Geographic Region/Country - Percentage Breakdown of Dollar
Sales for US, Europe and Rest of World Markets for Years 2006,
2014 & 2020 (includes corresponding Graph/Chart) II-71

III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Bone Graft Substitutes Market: Opportunities for Growth III-1
Bone Grafts Market - An Insight III-1
Aging Population: A Strong Demographic Driver III-2
Table 21: North American Elderly Population by Age Group
(1975-2050) (includes corresponding Graph/Chart) III-3

Table 22: US Population Breakdown by Age Group (2012)
(includes corresponding Graph/Chart) III-3
Rising Incidence of Degenerative Intervertebral Disc Diseases III-4
Back Pain III-4
Arthritis III-4
Table 23: % of Population Diagnosed with Arthritis by Age
Group (includes corresponding Graph/Chart) III-5
Osteoporosis III-5
Table 24: Osteoporosis Population in the US: 2002, 2005,
2008 & 2012 (includes corresponding Graph/Chart) III-6

Table 25: Breakdown of Osteoporotic Fractures by Site in
the US (includes corresponding Graph/Chart) III-6
Rise in Revision Orthopedic Surgeries III-6
Increasing Visibility of Orthobiological Products to Spur
Grafting Options III-7
Precision Machined Allograft Gain Surgeon Preference III-7
Unmet Clinical Needs to Foster R&D Engine III-7
Synthetic Bone Grafts to Fan Growth III-7
Spinal Surgery Market: Opportunity for Bone Grafts Market III-8
Dental Bone Graft Substitutes Market: An Overview III-8
Orthopedic Biomaterials Market - An Overview III-8
Regulatory Challenges Limit Growth in the US Orthopedic
Biomaterials Market III-9
Orthobiologics Market - Overview III-9
Adequate Reimbursement: An Impetus for Growth & Profitability III-10
Table 26: Payer Mix for Spinal (Cervical) Fusion Procedures
in the US (includes corresponding Graph/Chart) III-10
Table 27: Payer Mix for Spinal (Lumbar) Fusion Procedures
in the US (includes corresponding Graph/Chart) III-10
Competitive Scenario III-11
Standard Bone Allografts III-11
Table 28: US Market for Standard Bone Allografts (2012):
Percentage Market Share Breakdown of Leading Tissue
Processors (includes corresponding Graph/Chart) III-11
Machined Bone Allografts III-12
Table 29: US Market for Machined Bone Allografts (2012):
Percentage Market Share Breakdown of Leading Tissue
Processors (includes corresponding Graph/Chart) III-12
Demineralized Bone Matrix (DBM) III-12
Table 30: Leading Players in the US DBM Market (2012):
Percentage Breakdown of Sales for Synthes/DePuy Spine,
Medtronic, Integra, Bacterin, RTI Surgical, Wright
Medical, Exactech, Stryker, and Others (includes
corresponding Graph/Chart) III-13
Synthetic Bone Graft Substitutes III-13
Table 31: US Market for Synthetic Bone Graft Substitutes
(2012): Percentage Share Breakdown of Value Sales by
Company - Stryker, Wright Medical, Biomet, J&J, and Others
(includes corresponding Graph/Chart) III-13
Product Launches III-14
Strategic Corporate Developments III-19
Select Key Players III-22
B.Market Analytics III-31
Table 32: US Recent Past, Current and Future Analysis for
Bone Graft Substitutes by Product Segment - Standard
Allografts, Machined Bone Allografts, Demineralized Bone
Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell
Based and Synthetic Bone Grafts Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2012 through 2020 (includes corresponding Graph/Chart) III-31

Table 33: US Historic Review for Bone Graft Substitutes by
Product Segment - Standard Allografts, Machined Bone
Allografts, Demineralized Bone Matrix (DBM), Bone
Morphogenetic Protein (BMP), Stem Cell Based and Synthetic
Bone Grafts Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2006 through 2011 (includes
corresponding Graph/Chart) III-32

Table 34: US 15-Year Perspective for Bone Graft Substitutes
by Product Segment - Percentage Breakdown of Dollar Sales
for Standard Allografts, Machined Bone Allografts,
Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein
(BMP), Stem Cell Based and Synthetic Bone Grafts Markets for
Years 2006, 2014 & 2020 (includes corresponding Graph/Chart) III-33

2. EUROPE III-34
A.Market Analysis III-34
Outlook III-34
Orthopedic Biomaterials Market - Overview III-34
Table 35: European Bone Graft Substitutes Market (2012):
Percentage Share Breakdown of Value Sales for Synthetic,
Allograft, and DBM (includes corresponding Graph/Chart) III-34
Synthetic Bone Graft Market Drives the BGS Market III-35
Bone Morphogenetic Protein (BMP) Market III-35
Dental Biomaterials Market in Europe: An Insight III-35
Overview III-35
Medical Tourism Bodes Well for Dental Implants Market III-36
Turkey - Fastest Growing Dental Implant Market III-36
Competitive Scenario III-36
Key Statistical Data III-37
Table 36: European Market for Standard Bone Allografts
(2012): Percentage Share Breakdown of Revenues by Leading
Companies/ Organizations (includes corresponding
Graph/Chart) III-37

Table 37: European Market for Machined Bone Allografts
(2012): Percentage Share Breakdown of Revenues by Leading
Companies/ Organizations (includes corresponding
Graph/Chart) III-37

Table 38: European Market for Demineralized Bone Matrix
(2012): Percentage Market Share Breakdown of Revenues by
Leading Companies/ Organizations (includes corresponding
Graph/Chart) III-38

Table 39: European Market for Bone Graft Substitutes
(2012): Percentage Share Breakdown of Value Sales by
Leading Players (includes corresponding Graph/Chart) III-38
Regulatory Overview III-39
EU Directive 2003/32/EC III-39
DBM-based Products in Europe & Rest of World III-39
Product Launches III-39
Strategic Corporate Developments III-40
Smith & Nephew Plc - A Key Player III-40
B.Market Analytics III-41
Table 40: European Recent Past, Current and Future Analysis
of Bone Graft Substitutes Market Analyzed with Annual Sales
Figures in US$ Million for Years 2012 through 2020 (includes
corresponding Graph/Chart) III-41

Table 41: European Historic Review of Bone Graft Substitutes
Market Analyzed with Annual Sales Figures in US$ Million for
Years 2006 through 2011 (includes corresponding Graph/Chart) III-42

3. REST OF WORLD III-43
A.Market Analysis III-43
Outlook III-43
Focus on Select Regional Markets III-43
Asia-Pacific III-43
Dental Bone Graft Substitutes and Biomaterials Market - An
Overview III-43
Table 42: Over 65 Years Individuals as % of Total
Population in Select Asian Countries (includes
corresponding Graph/Chart) III-43
India III-43
Orthopedic Biomaterials and Dental Bone Grafts Market - An
Insight III-43
Rise in Medical Tourism Drives Bone Grafts Market III-44
China III-44
Orthopedic Biomaterials Market - A Review III-44
Malaysia III-44
Singapore III-44
A Major Hub for Spine, Knee and Hip Surgeries III-44
Latin America III-45
Dental Bone Graft Substitutes Market - Overview III-45
Overview of Brazilian Orthopedic Devices Market III-45
Japan III-45
Orthopedic Devices Market - Overview III-45
Canada III-45
Favorable Growth Prospects in Bone Graft Substitutes Market III-45
Product Launches III-46
B.Market Analytics III-47
Table 43: Rest of World Recent Past, Current and Future
Analysis of Bone Graft Substitutes Market Analyzed with
Annual Sales Figures in US$ Million for Years 2012 through
2020 (includes corresponding Graph/Chart) III-47

Table 44: Rest of World Historic Review of Bone Graft
Substitutes Market Analyzed with Annual Sales Figures in US$
Million for Years 2006 through 2011 (includes corresponding
Graph/Chart) III-48

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 61 (including Divisions/Subsidiaries - 72)

The United States (53)
Europe (15)
- France (3)
- Germany (2)
- The United Kingdom (4)
- Rest of Europe (6)
Asia-Pacific (Excluding Japan) (3)
Africa (1)

Read the full report:
Global Bone Grafts Industry

http://www.reportbuyer.com/pharma_healthcare/healthcare/global_bone_grafts_industry.html

For more information:
Sarah Smith
Research Advisor at Reportbuyer.com
Email: query@reportbuyer.com  
Tel: +44 208 816 85 48 
Website: www.reportbuyer.com

SOURCE ReportBuyer



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