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Global cell free protein expression market dynamics
The primary factors fuelling demand for cell free protein expression market are increasing R&D outsourcing by pharmaceutical and biotechnological companies, declining R&D productivity and patent cliff sales drop leading to increasing research intensity in the pharmaceutical sector and increasing expenditure on biosimilar development. Other factors driving cell free protein expression market are a growing demand for simple and efficient protein production methods, contamination free approach and increasing focus on production of mammalian cell free lysate due to drug discovery.
One of the major bottleneck in the cell free protein expression market is the low protein production volumes in the process. This limitation makes cell free protein expression unsuitable for large industrial applications and is generally preferred in small R&D processes. However, efforts are being made to overcome this constraint and make it a preferred expression system in industrial settings.
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Global cell free protein expression market forecast
The market is segmented based on product type, application, expression mode, end users, and region. Based on product type, the market has been segmented into E. coli cell-free protein expression system, rabbit reticulocytes cell-free protein expression system, wheat germ cell-free protein expression system, insect cells cell-free protein expression system, mammalian cell-free protein expression system, and consumables (labelling tags, vectors).
Mammalian cell-free protein expression system segment is expected to grow with the fastest CAGR over the forecast period, owing to increasing usage of mammalian cell lysate in humanized proteomic and biologics study. The segment is expected to register a significant CAGR of 6.0% during the forecast period. Wheat germ cell-free protein expression system is also anticipated to witness a CAGR of 5.8% over the forecast period. The rapidly increasing demand for simpler, rapid and efficient protein production methods is boosting the cell-free protein expression market in research and development field.
The market has been segmented based on major applications such as enzyme engineering, protein labelling, protein-protein interaction, and protein purification. The protein-protein interaction segment is expected to register the highest CAGR of 6.0% over the forecast period due to increasing number of proteomic studies. The simple presentation of cell-free protein expression system makes it easier to integrate them into high throughput platforms for efficient biologics and proteomics studies. Cell-free protein expression systems allow protein screening without necessitating a gene-cloning step thus enabling an accelerated process/product development pipelines which makes up for attractive opportunity for market players.
Based on end users, the market has been segmented into biotechnological companies, pharmaceutical companies, contract research organizations, and academic/research institutes. The academic/research institutes is anticipated to account for the highest market share over the forecast period, registering a CAGR of 6.1% due to vast research applications in the protein libraries generation for functional genomic studies, customized drug development studies, and the expression of virus-like particles, among many other applications.
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This report assesses trends, that drive growth of each segment on the global as well as regional levels, and offers potential takeaways, that could prove substantially useful to biopharmaceutical manufacturing companies who wish to enter into the cell free protein expression market. North America and Europe are expected to dominate the cell free protein expression market with maximum market share in 2016. North America and Europe collectively, are expected to account for more than 65% of the total cell free protein expression market share in terms of value in 2016. Among emerging markets, Asia Pacific is estimated to exhibit the highest CAGR of 6.1% over the forecast period, due to increase in the research and development expenditure in the region.
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Global cell free protein expression market competitive landscape
Some key players in the global cell free protein expression market identified in the report include Thermo Fisher Scientific, Jena Bioscience GmbH, New England Biolabs, biotechrabbit GmbH, Bioneer Corporation, Promega Corporation, Cube Biotech GmbH, Takara Bio, Inc., CellFree Sciences Co., Ltd., and GeneCopoeia, Inc. We have discussed individual strategies of these companies in terms of increasing focus on protein yield, initiatives to increase sales, and enhancing distribution base. The report has been concluded with strategic recommendations for players already present in the market and new players planning to enter the market, which could help them in the long run.
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