"The findings published today build upon other work by Infinity and our collaborators, reinforcing the therapeutic potential of Infinity's selective PI3K-gamma inhibitor, IPI-549, to alter the immune-suppressive microenvironment, promoting an anti-tumor immune response that leads to tumor growth inhibition," stated Jeffery Kutok, M.D., Ph.D., vice president of biology and translational science at Infinity Pharmaceuticals and a co-author of the paper. "Infinity is excited to be at the forefront of advancing PI3K-gamma inhibition as a new immunotherapeutic approach that could potentially enhance existing treatment options, including checkpoint inhibitors."
When confronted by pathogens, injury or disease, the initial response of the body's immune system comes in the form of macrophages, a type of white blood cell that express pro-inflammatory proteins called cytokines that, in turn, activate T cells, another immune cell, to attack the health threat. The macrophages then switch gears to express other cytokines that dampen T cell activation, stimulating tissue repair. In cancer, highly abundant macrophages express anti-inflammatory cytokines that induce immune suppression, leading to enhanced tumor growth.
In the Nature paper, researchers pinpoint a key, suspected player: an enzyme in macrophages called PI3K-gamma. In mouse studies, they found that macrophage PI3K-gamma signaling promotes immune suppression by inhibiting activation of anti-tumor T cells. Blocking PI3K-gamma activated the immune response and significantly suppressed growth of implanted tumors in animal models. It also boosted sensitivity of some tumors to existing anti-cancer drugs and synergized with existing immune therapy to eradicate tumors. Researchers also identified a molecular signature of immune suppression and response in mice and cancer patients that may be used to track the effectiveness of immune therapy.
Earlier this year, Infinity initiated its first clinical study of IPI-549 designed to explore safety, tolerability, pharmacokinetics and pharmacodynamics of IPI-549 as a monotherapy and in combination with an anti-PD-1 antibody, a checkpoint inhibitor, in approximately 150 patients with advanced solid tumors, including non-small cell lung cancer and melanoma.2
"Infinity's first clinical study of IPI-549 is progressing well, and we expect to initiate the first combination therapy cohort this Fall," said Julian Adams, Ph.D., president, research and development at Infinity. "We also look forward to the presentation of early clinical and new preclinical data at an immuno-therapy conference later this month."
Recently, Infinity announced that new preclinical data as well as early clinical data from the ongoing Phase 1 study will be presented for IPI-549 during the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival taking place September 25-28, 2016, in New York City. The IPI-549 presentations will take place during the poster session being held on Monday, September 26, from 5:15 p.m. – 7:45 p.m. ET (Poster Boards B070 and B032).
IPI-549 is an orally administered immuno-oncology development candidate that selectively inhibits PI3K-gamma. In preclinical studies, IPI-549 inhibits immune-suppressive macrophages within the tumor microenvironment, whereas other immunotherapies such as checkpoint modulators more directly target immune effector cell function. As such, IPI-549 may have the potential to treat a broad range of solid tumors and represents a potentially complementary approach to restoring anti-tumor immunity in combination with other immunotherapies such as checkpoint inhibitors.
IPI-549 is an investigational compound and its safety and efficacy has not been evaluated by the U.S. Food and Drug Administration or any other health authority.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including those regarding the company's expectations about the timing and type of data presentations and the therapeutic potential of PI3K-gamma inhibition and of IPI-549, alone or in combination with other agents. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from the company's current expectations, including, for example, that there is no guarantee that IPI-549 will successfully complete necessary preclinical and clinical development phases, or gain regulatory approval and other risks described in greater detail under the caption "Risk Factors" included in Infinity's quarterly report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on August 9, 2016, and other filings filed by Infinity with the SEC. Any forward-looking statements contained in this press release speak only as of the date hereof, and Infinity expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.
Jaren Irene Madden, Senior Director, Investor Relations and Corporate Communications
617-453-1336 or Jaren.Madden@infi.com
1 Kaneda, M.M., Messer, K.S., Ralainirina N. et al. Nature, Advanced Online Publication, September 2016, http://www.nature.com/nature.
2 www.clinicaltrials.gov, NCT02637531
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SOURCE Infinity Pharmaceuticals, Inc.