NEW YORK, Oct. 8, 2015 /PRNewswire/ -- Mass spectrometry for proteomics research, crucial to discovering and developing new drug treatments, is an $800 million-dollar business, according to Kalorama Information. The molecular detection tool is able to separate ionized molecules by their mass/charge ratio and detect their relative abundance in a vaporized sample. The finding was made in the company's report Proteomics Research Markets: Instruments (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other) Market Share and Trends.
The report said that mass analysis is crucial to all stages of proteomic biomarker research, from global and targeted discovery through differential analysis and absolute quantitation during biomarker verification and validation. Instrument performance has been the greatest deciding factor for market sales with Thermo Fisher Scientific's line of Orbitrap MS systems finding by far the greatest recent market success. Orbitrap technology offers leading resolution for discovery processes surpassed only by Fourier transform mass spectrometry (FT-MS). Orbitraps represent an adaptation of FT-MS that is better suited to research labs in terms of physical footprint, cost, and more user-friendly operation.
The report says that four companies lead in this market:
- Waters Corporation offers LC-MS systems able to address bottom-up shotgun proteomics through MRM quantitation in verification. Waters' leading business is in separation and offers gas chromatography (GC), LC and supercritical or convergence chromatography (CC) systems and products for various end markets. Proteomics-oriented Waters separation systems are the flagship ACQUITY and nanoACQUITY systems, which are a unique strength to the company as part of a total vendor solution in LC-MS for comprehensive protein discovery and characterization (using data-independent acquisition) as well as quantitation workflows (high-definition multiple reaction monitoring [HD-MRM]).
- Thermo Fisher Scientific is a leading player in the proteomics research market through the merits of its hybrid Orbitrap MS systems competitive in discovery and verification workflows as well as its proteomic quantitation reagents. Following its 2010 acquisition of LC specialist Dionex, Thermo Fisher is also a significant provider of front-end separation systems for proteomics research. Orbitrap technology offers leading resolution
- Agilent Technologies offers QqQ-, TOF- and ion trap-based MS systems for proteomic applications. The strengths of Agilent's proteomics research portfolio are its updated triple quadrupole and Q-TOF systems appropriate for current strategies in translational research for biomarkers (high-resolution, high-speed discovery acquisition strategies followed by QqQ-based quantitative assay development). Agilent's 6200 Series TOF and 6300 Series ion trap MS systems are increasingly obsolete in light of the high-powered mass analysis required in proteomics research.
- AB Sciex is a leader in high-end mass spectrometry instrumentation with high-performance solutions for drug development and life science research including proteomics research. The company has comprehensive coverage over the proteomics MS market with hybrid triple quadrupole-linear ion trap (Q-LIT), hybrid triple quadrupole-time of flight (Q-TOF), tandem TOF (TOF/TOF) and triple quadrupole (QqQ) that address research workflows from targeted and global discovery through quantitative analyses for target and biomarker verification and validation.
Specific company revenues and market share positions are provided in Kalorama Information report, Proteomics Research Markets: Instruments (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other) Market Share and Trends. The report also describes current best practices in proteomics, identifies key trends and estimates disease-specific market segments. The report is available at: http://www.kaloramainformation.com/redirect.asp?progid=87894&productid=8989207.
About Kalorama Information
Kalorama Information, a division of MarketResearch.com, supplies the latest in independent medical market research in diagnostics, biotech, pharmaceuticals, medical devices and healthcare; as well as a full range of custom research services. Reports can be purchased through Kalorama's website and are also available on www.marketresearch.com and www.profound.com.
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SOURCE Kalorama Information