BIRMINGHAM, Ala., Oct. 5, 2016 /PRNewswire-USNewswire/ -- Newswise - Southern Research has been awarded a five-year IDIQ contract with a potential value of $19 million from the National Cancer Institute (NCI) to study the preclinical toxicology of new drugs that are under development for treatment of cancer -- contract number HHSN261201600018I.
The toxicology contract is one of three ongoing contracts between Southern Research and the NCI, and is the latest in a series of contracts with the NCI that have been in place continuously since 1979.
The two additional ongoing contracts between Southern Research and the NCI are for research on the pharmacology of potential new cancer drugs, and for evaluation of drugs intended for the prevention of cancer.
"Our ultimate goal with this contract is to help the NCI develop an understanding of how different drug candidates interact with and affect living systems," said Charles Hebert, Ph.D., senior program leader and principal investigator on the project for Southern Research. "The collection of this information is necessary so the FDA can determine whether a particular drug candidate is safe for clinical trial testing in humans."
Toxicology testing is an integral part of the drug development process. In order to determine the safety of a new drug candidate, researchers must first conduct dose range-finding studies to establish the maximum tolerated dose, and to aid in the selection of dose levels for use in further testing.
Once the appropriate dose range has been established for the selected species, larger and more detailed definitive studies are conducted. Those definitive studies differs from dose range-finding studies in that they require deeper and more thorough analysis of the ways a particular drug may affect animals, and by extension, humans. Ultimately, the definitive studies provide key information that is used by the FDA to determine the recommended dose options for any drug candidate approved for clinical trial.
"Southern Research has been at the pioneering forefront of cancer research for more than 70 years, and we are particularly proud of our work with the National Cancer Institute," said Art Tipton, Ph.D., president and CEO of Southern Research. "We have invested heavily to develop unique capabilities and institutional knowledge in this field, and work diligently to stay on the forefront of the field enabling us to improve people's lives by finding cures to some very challenging diseases."
About Southern Research
Southern Research is a not-for-profit 501(c)(3) research institution with nearly 500 scientists and engineers working to solve some of the world's hardest problems across four key divisions: Drug Discovery, Drug Development, Engineering, and Energy & Environment. Founded in 1941, 2016 marks Southern Research's 75 Anniversary. Over this time, the institution built a trusted name for itself, and has continually worked with some of the world's leading organizations, including the National Cancer Institute, National Institutes of Health (NIH), the U.S. Department of Defense, the U.S. Department of Energy, NASA, several major aerospace firms, the nation's largest utility companies, and other private and government organizations. Headquartered in Birmingham, Southern Research has additional laboratories and offices in Wilsonville and Huntsville, Alabama; Frederick, Maryland; Durham, North Carolina; Cartersville, Georgia; and Houston, Texas. For more information, please visit www.SouthernResearch.org.
Rossi Carlson, 205-581-2266, email@example.com
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SOURCE Southern Research