ScinoPharm has a strong relationship with CVie for the supply of API for CVie's clinical trials. CVie's long-standing expertise in the indication of heart failure via small-molecule therapeutics furnishes a solid foundation on which to discover the desired new generation compound to Istaroxime. ScinoPharm's experience in drug discovery, chemistry route development, and CMC operations is a perfect complement to CVie's existing assets and resources.
ScinoPharm CEO Dr. Yung Fa Chen stated, "ScinoPharm is transforming into a full-scope specialty pharma based on our core competencies of strong R&D and cGMP manufacturing in high-entry barrier APIs. This collaboration with CVie signals ScinoPharm's strategic move into the new drug development field. From both scientific and business perspectives, we are very excited for this alliance."
CVie President and COO, Dr. Lit-Fui Lau, said, "The partnership between ScinoPharm and CVie will take advantage of the strengths of both companies toward the discovery of the orally available Istaroxime analogs for the treatment of acute and chronic heart failure. It creates a win-win situation for both companies and exemplifies a productive collaborative model in discovering novel medicines of value to patients."
Istaroxime is a first-in-class luso-inotropic agent under development for the treatment of acute decompensated heart failure. It possesses a unique dual mode of action, combining inotropic (myocyte contraction) and lusotropic (myocyte relaxation) effects. Istaroxime is a potent positive inotropic agent that increases myocardial contractility through inhibition of Na+/K+-ATPase. In addition, it stimulates myocardial relaxation through activation of the SERCA 2a calcium pump on the sarcoplasmic reticulum and reduction in cytoplasmic calcium. Based on its mechanism of action, preclinical studies and early clinical findings, it is anticipated that Istaroxime will have minimal deleterious effects of conventional inotropes, i.e., increased heart rate, increased oxygen consumption, increased risk of arrhythmia and hypotension.
CVie is a Taiwan-based joint venture founded in 2013 by Lee's Pharmaceutical Holdings Limited and renowned venture capitals from the US and Taiwan. It is a stand-alone drug development company specialized in cardiovascular diseases. CVie currently owns two phase IIb assets that target cardiovascular diseases with significant unmet medical need. Rostafuroxin is a novel precision medicine targeting hypertensive patients with certain genetic profiles with better efficacy and safety than conventional therapies. Istaroxime is a first-in-class luso-inotropic medicine for the treatment of acute heart failure and will have fewer adverse effects than conventional inotropes, namely, increased heart rate, arrhythmia, increased oxygen consumption, hypotension, etc.
ScinoPharm Taiwan, Ltd. is a leading process R&D and API manufacturing service provider to the global pharmaceutical industry. With research and manufacturing facilities in both Taiwan and mainland China, ScinoPharm offers a wide portfolio of services ranging from custom synthesis for early phase pharmaceutical activities for brand companies as well as APIs for the generic industry. The Company also is aggressively pursuing a vertically integrated, one-stop-shopping service for drug product customers by expanding into the field of sterile oncological injectable formulations.
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SOURCE ScinoPharm Taiwan, Ltd.; CVie Therapeutics Limited