The clinical trial will be run by principal investigators at Dana Farber Cancer Institute, Boston; and Sarah Cannon Research Institute, Nashville.
Immunotherapy rarely controls clinically significant tumors that fail to express target antigens, and thereby fail to elicit an effective immune response. However, there is mounting evidence that tumor antigen production can be precisely stimulated to promote immune recognition and response.
NEV-801 is a simultaneous multi-inhibitor of Topoisomerase I and Topoisomerase II activity, HIF-1 transcriptional activation, and hypoxic induction of VEGF mRNA and protein expression, targeting Werner syndrome protein (WRN) (a RecQ helicase), thereby overcoming MDR gene 1-mediated resistance. The simultaneous inhibition of multiple cancer pathways forces distressed tumors to express target antigens, thereby potentially enhancing the efficacy of immunotherapy.
"Patient enrollment marks the formal beginning of a clinical trial and so we are excited to get underway after much preparation and hard work by our team," said Trevor Blake, Co-founder and CEO, "This is the first program to have advanced through Neovia's innovative development pipeline that includes more than 60 potential drugs. It represents a milestone in the transition of the company from pre-clinical to clinical-stage and validates us to potential investors and partners who can now help us grow and provide more potential therapies to cancer patients."
About Neovia Oncology
Neovia Oncology, founded by two successful pharmaceutical entrepreneurs, is developing safe, multi-inhibitor cancer drugs that enhance immune response to overcome drug resistance. We are actively seeking partners and investors to help us expand our clinical projects and progress from a private to public company in the near future. (www.neoviaoncology.com) Neovia has locations in Seattle, USA and Beijing, China
Trevor Blake, Founder & CEO (Seattle)
Gerald Su, COO (Beijing)
(P) Beijing: +86.139.1131.8550
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SOURCE Neovia Oncology Ltd