Symic Biomedical Selects Osteoarthritis Clinical Candidate

- SB-061 Mimics the Protective Proteoglycan, Aggrecan, to Reduce Cartilage Degradation and Pain -

17 Nov, 2015, 08:00 ET from Symic Biomedical

SAN FRANCISCO, Nov. 17, 2015 /PRNewswire/ -- Symic Biomedical, a clinical-stage biotherapeutics company developing multiple compounds that target and affect the extracellular matrix (ECM), today announced the selection of SB-061 as the company's first osteoarthritis clinical candidate. In preclinical studies, SB-061 was shown to reduce pain and cartilage degradation in models of osteoarthritis. SB-061, which will be administered as an intra-articular injection, is designed to prevent the degradation of cartilage by mimicking the protective effect of the proteoglycan aggrecan.

"Today, there are no treatments available for the underlying structural progression of osteoarthritis, a disease that affects approximately 30 million Americans," said Ken Horne, Chief Executive Officer of Symic Biomedical. "Current options for managing the symptoms of osteoarthritis are only palliative, whereas we believe that SB-061 has the potential to both address pain and to modify the disease itself. Symic expects to enter the clinic with SB-061 in the second quarter of 2016."

Osteoarthritis is the most common form of arthritis that occurs when the cartilage in the joint degrades over time. Within cartilage, which is primarily comprised of ECM, aggrecan is the dominant proteoglycan, playing an important role in cartilage structure. For patients with osteoarthritis, aggrecan is lost leading to the degradation of the ECM itself and chronic inflammation of the joint. Available options for the symptoms associated with osteoarthritis are oral agents (acetaminophen, NSAIDs) and intra-articular agents (steroids for limited use, viscosupplementation). Ultimately, patients may resort to total joint replacement, which resulted in an estimated $28.5 billion in hospital expenditures in the U.S. in 2009, according to the CDC1. In contrast, SB-061 mimics aggrecan and binds to the cartilage ECM to protect the remaining cartilage from further degradation, which may ultimately lead to disease modification.

1 http://www.cdc.gov/arthritis/basics/osteoarthritis.htm  

About Symic Biomedical

Symic Biomedical is a clinical-stage biotherapeutics company developing multiple compounds that target and affect the extracellular matrix (ECM). Symic's proprietary compounds function like proteoglycans, important structural and functional macromolecules native to the ECM, which is the non-cellular component of tissues that is critical for healthy tissue function. Components of the ECM, particularly proteoglycans, play a critical role in healing following injury and in chronic diseases. SB-030 is Symic's lead compound under evaluation in the Phase 1/2 clinical study for vascular endothelial injury.

Symic Biomedical is based in San Francisco. For additional information, please visit the company's website at http://www.symic.bio or follow us on Twitter at www.twitter.com/symicbio and LinkedIn at www.linkedin.com/company/symic-bio/.

Media Contacts

David Schull or Lena Evans
Russo Partners, LLC
(212) 845-4271
(212) 845-4262
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SOURCE Symic Biomedical



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