"This study debunks the concern that patients who are not clinically stable are not capable of using mobile interventions."
Dror Ben-Zeev, PhD, Director of the mHealth for Mental Health Program at Dartmouth College
The study demonstrated robust usage of and engagement with the research version of THRIVE™. Seventy-four percent (73.6%) of patients were successfully able to use the digital therapy 3-6 months after discharge, and on average, participants used the digital therapy for 82% of the weeks they had a mobile phone. The study found that patients engaged with the app every other day, and when engaged, they used on-demand features more than once per day. Patients who used the app for the entirety of the study averaged 4.3 days of use per week.
In previous studies, the digital therapy has shown efficacy in treating schizophrenia across a 33-patient longitudinal study where patients demonstrated an 8% improvement in the Positive and Negative Syndrome Scale (PANSS), the primary endpoint in clinical trials for schizophrenia treatments. Study participants, already taking antipsychotics at study start, were offered access to the research version of THRIVE™ and followed over 1 month of use, during which time patients engaged with the digital therapy 86.5% of days they had the device, an average of 5.2 times a day. The research version of THRIVE™ is being or has been evaluated across 7 clinical studies in 504 patients.
"Patients with schizophrenia are traditionally considered a high risk patient population and the period immediately following hospitalization is of particularly high risk. This study debunks the concern that patients who are not clinically stable are not capable of using mobile interventions," said Dror Ben-Zeev, PhD, Director of the mHealth for Mental Health Program at Dartmouth College.
"Coupled with prior results demonstrating enhanced outcomes in patients with schizophrenia-spectrum disorders, this study suggests that THRIVE™ could be an efficacious, long-lived therapeutic intervention. We are particularly excited to have the opportunity to bring THRIVE™ through regulatory approval and payor reimbursement. We are committed to making this product part of the standard of care for treating Serious Mental Illness," said Corey McCann, President and Chief Executive Officer of PEAR.
THRIVE is a digital therapy for treating patients with schizophrenia, schizoaffective disorder, and bipolar disorder. THRIVE delivers daily prompts to encourage patient engagement, and contains therapeutic modules that offer content designed to help individuals manage their disease. Modules include content designed to manage positive symptoms of schizophrenia and support medication adherence, with a specific emphasis on voices, social function, medication adherence, sleep behaviors, and mood.
About Pear Therapeutics
Pear Therapeutics is a privately held eHealth company with offices in Boston and San Francisco. The Company develops digital therapies to address a broad range of severe conditions including addiction, schizophrenia, pain, post-traumatic stress disorder, anxiety, depression, and insomnia. PEAR's eFormulation™ platform combines pharmaceutical preparations with user-friendly, customizable, and scientifically validated software applications. PEAR's patented approach provides better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. For additional information please visit: www.peartherapeutics.com.
The publication referenced was part of a multi-state project funded by the Center for Medicare and Medicaid Innovation (CMMI) and led by PI Dr. John Kane at the Zucker Hillside Hospital. The effort included a team of researchers from multiple institutions, including Dr. Dror Ben-Zeev. In the project, FOCUS, the research version of PEAR's digital therapy THRIVE™ was deployed as part of a multi-component relapse prevention effort called Improving Care Reducing Costs (ICRC). ICRC was the first comprehensive technology-aided program of its kind for people with schizophrenia who were recently discharged from psychiatric hospitalization.
Thrive™ is an investigational device. Limited by Federal law to investigational use. Not available for commercial sale in the U.S.
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/the-largest-and-longest-study-of-patients-with-schizophrenia-interacting-with-digital-therapeutics-results-released-300318060.html
SOURCE Pear Therapeutics