"TSRI's chemistry department is known for its rich history of innovation, and that has never been more true than today," said TSRI President Peter Schultz, Ph.D. "We are delighted to partner with Pfizer in an area where pioneering chemical methodologies can have a significant impact on the discovery of new medicines for unmet medical needs."
In contrast to conventional drug screening where a few million small molecules are evaluated in biological systems, DEL screening uses DNA-based "barcodes" to survey billions of small molecules, potentially increasing the ability of researchers to identify promising chemical leads. While this technology was originally conceived at TSRI by Richard Lerner, M.D., and Sydney Brenner, Ph.D., in the early 1990s, the reduction to practice has taken decades and required technological advances in DNA sequencing and informatics in order to be more fully realized.
"We look forward to continuing our longtime relationship with TSRI," said Tony Wood, Senior Vice President and Head of Medicinal Sciences, Pfizer. "We hope that this new collaboration will contribute to the creation of novel chemistries that can be used by Pfizer to prepare unique libraries for screening which, together with our parallel medicinal chemistry expertise, will have the potential to help us accelerate the discovery of new medicines for patients."
About The Scripps Research Institute
The Scripps Research Institute (TSRI) is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs more than 2,500 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists—including two Nobel laureates and 20 members of the National Academies of Science, Engineering or Medicine—work toward their next discoveries. The institute's graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. In October 2016, TSRI announced a strategic affiliation with the California Institute for Biomedical Research (Calibr), representing a renewed commitment to the discovery and development of new medicines to address unmet medical needs. For more information, see www.scripps.edu.
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SOURCE The Scripps Research Institute