Zenith Epigenetics continues to advance its single agent Phase 1 clinical trial with ZEN-3694, working with prominent clinical investigators and the Prostate Cancer Clinical Trial Consortium ("PCCTC") who collectively have been instrumental in developing leading drugs for the treatment of mCRPC, including enzalutamide and abiraterone (Xtandi and Zytiga respectively).
Zenith Epigenetics has also developed strong pre-clinical rationale for developing ZEN-3694 in other oncology indications which may be explored in future clinical programs.
Additional trial details and updates can be found at: www.clinicaltrials.gov.
mCRPC is a major unmet medical need due to its widespread occurrence and incurable status. Current standard of care for this disease are androgen receptor (AR) antagonists (enzalutamide) or androgen synthesis inhibitors (abiraterone). While most patients display an initial response to these agents, eventually even responding patients develop drug resistance via various mechanisms. There is currently no effective therapy for these patients. Recent pre-clinical evidence has shown that bromodomain (BET) inhibitors can be efficacious in mCRPC patients that are resistant to current therapies.
Zenith Capital Corp. is a biotechnology investment company. Zenith Epigenetics Ltd., a wholly-owned subsidiary of Zenith Capital Corp., is a clinical stage biotechnology company focused on the discovery and development of novel therapeutics. Zenith Epigenetics Ltd.'s bromodomain (BET) inhibitors are being advanced in several oncology indications and have the potential to impact multiple additional diseases as well. The lead compound, ZEN-3694, is in clinical development for mCRPC.
SOURCE Zenith Capital Corp.