Mesenchymal Stem Cells - Advances & Applications

LONDON, Feb. 11, 2016 /PRNewswire/ -- Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, beta-pancreatic islets cells, and a limited range of other cell types MSCs are of intense therapeutic interest, because they represent a population of cells with the potential to treat a range of acute and degenerative diseases They are advantageous over other stem cells types for a variety of reasons They avoid the ethical issues that surround embryonic stem cell research, and repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogenic transplantation MSCs also being explored for use in 3D printing applications, because of their unique capacity to form structural tissues

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Mesenchymal Stem Cells – Advances & Applications
Mesenchymal Stem Cells – Advances & Applications

Category: Stem Cell Market Research Tags: adipose-tissue, market research, mesenchymal stem cells, stem cells, strategy, trends
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Global Strategic Report
250 Pages; November 2015

Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, beta-pancreatic islets cells, and a limited range of other cell types MSCs are of intense therapeutic interest, because they represent a population of cells with the potential to treat a range of acute and degenerative diseases They are advantageous over other stem cells types for a variety of reasons They avoid the ethical issues that surround embryonic stem cell research, and repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogenic transplantation MSCs also being explored for use in 3D printing applications, because of their unique capacity to form structural tissues

The report describes the current status of MSC research, ongoing clinical trials involving MSCs, late stage MSC clinical trials, and possible uses of MSCs in cell therapy Because MSCs are a sub-segment of the broader cell therapy (CT) and regenerative medicine (RM) markets, it also gives an overview of the regenerative medicine industry and overall cell therapy industry

It also explores recent advances in MSC products and technologies, identifies research priorities by market segment, and assesses 35 leading competitors within the MSC marketplace For pharmaceutical companies, it reveals how advances in MSC research can reveal potential new drug targets, improve methods of drug delivery, and provide personalized treatment strategies

There is substantial potential for growth within the MSC market, with more than 30,000 scientific publications published about the cell type, more than 400 clinical trials underway worldwide, and Google Trend data showing MSC searches to be approximately twice as common as the next most common stem cell type

Therefore, the main objectives of the report are to consider the following:

Current status of global regenerative medicine (RM) industry in the utilization of stem cells in general and MSCs in particular
Current status of global cell therapy (CT) industry, the application of cell therapy in various disease indications, and the total number of clinical trials involving the different types of stem cells
Current status of MSCs in clinical trials, the dominance of MSCs in the ongoing clinical trials involving stem cells, the various applications of MSCs in different disease indications, and the number of clinical trials involving MSCs for different disease types
The number of companies involved in the development of MSCs, the clinical trials sponsored by major companies, and their ongoing search for MSCs-based cell therapy products
Analysis of traditional market metrics (grant rates, clinical trial rates, patent rates, scientific publication rates) and new social analytics (metrics from social media sites, search engines, Google Trends, and more)

Key questions answered in the report are:
(Regenerative Medicine = RM; Cell Therapy= CT)

How many companies are currently supporting the regenerative medicine (RM) industry?
What is the current regional breakdown of RM industry?
How many RM products have been approved?
What are the types of diseases are currently being pursued by RM companies?
What are the major financial events, partnerships and acquisitions in RM sector?
How do the large pharma companies perceive the value and long-term prospects of RM and cell therapy (CT)?
What are the major anticipated RM clinical events in 2015-16?
What are the major therapeutic opportunities for the big pharma in RM and CT?
How many CT product candidates have reached the Phase IIIstage and what are they?
What are the CT product candidates being developed for cardiovascular diseases, central nervous system, wounds, spine and orthopedics, diabetes and autoimmune diseases?
What are the major commercially available CT products?
What is the total number of CT clinical trials at the global level?
What are the major cell types used in CT clinical trials?
What are the major indications addressed by CT clinical trials?
What are the major CT clinical trials that have reached Phase III?
How many CT clinical trials failed in the past year and what are they?
What are the contributions of MSCs to the cell therapy industry?
What are the biological properties of MSCs?
What do MSCs get differentiated into?
What bioactive molecules do the MSCs secrete?
What are the immunomodulatory functions of MSCs?
What are the factors impacting the acquisition of MSCs?
What are the various sources of MSCs?
What are the ongoing clinical trials using bone marrow-derived MSCs (BMMSCs) for kidney diseases?
What are the major clinical trials focusing on diabetes using BMMSCs?
What are the major clinical trials involving BMMSCs for cardiovascular diseases?
What are the major clinical trials focusing on liver diseases by BMMSCs?
What are the brain-related diseases addressed by clinical trials using BMMSCs?
How many clinical trials are conducted for intestinal diseases using MSCs?
What are the details of clinical trials conducted for musculoskeletal diseases using MSCs?
Number of clinical trials using MSCs derived from Wharton's jelly for various diseases?
What are the disease indications addressed by umbilical cord blood-derived MSCs (UCBMSCs) in current clinical trials?
What is the current number of clinical trials using MSCs?
How many major clinical trials using MSCs have reached the Phase III?
What are the MSCs-based cell therapy products available in the market?
What is the current size of the MSC marketplace?

The content and metrics contained in this report were compiled using a broad range of sources, including:

Stem Cell Grant Databases (RePORT Database, CIRM, MRC, Wellcome Trust – UK)
Stem Cell Patent Databases (United States Patent and Trade Office, World Intellectual Property Organization)
Stem Cell Clinical Trial Databases (ClinicalTrialsgov, International Clinical Trials Registry Platform, European Union Clinical Trials Register )
Stem Cell Scientific Publication Databases (PubMed, Highwire Press, Google Scholar)
Stem Cell Product Launch Announcements (Trade Journals, Google News)
Stem Cell Industry Events (Google News, Google Alerts)
Stem Cell Company News (SEC Filings, Investor Publications, Historic Performance)
Interviews with Stem Cell Industry Leaders and Executives
SEC Filings and Related Investor Publications
Social Analytics Tools for Twitter, LinkedIn, Google Search, and Google Trends
BioInformant's Proprietary Dashboard of MSC Industry Metrics and 10-Year Historical Database

35 companies are profiled in this report, including:

American Type Culture Collection Inc (ATCC)
Anterogen Co, Ltd
Apceth GmbH & Co KG
BioCardia Inc
BioRestorative Therapies Inc
Bone Therapeutics SA
BrainStorm Cell Therapeutics Inc
CellGenix Technologie Transfer GmbH
Celprogen Inc
CellTherapies P/L
Cesca Therapeutics Inc
Cyagen Biosciences Inc
Cynata Therapeutics Ltd
Cytori Therapeutics Inc
Escape Therapeutics
Genlantis
Kite Pharma Inc
Life Technologies Corporation
Lonza Group Ltd
Medipost Co Ltd
Mesoblast Ltd
NuVasive Inc
Ocata Therapeutics Inc
Organogenesis Inc
Orthofix International NV
Osiris Therapeutics Inc
Pluristem Therapeutics Inc
PromoCell
Regeneus Ltd
ScienCell Research Laboratories
STEMCELL Technologies Inc
Stemedica Cell Technologies Inc
Stempeutics Research Pvt Ltd
TiGenix NV
Vericel Corporation
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